Category: pyridine-derivatives

Gimenez Plaza, J. published the artcile2-Pyridylaldehyde 2-pyridylhydrazone as an analytical reagent. VI. Spectrophotometric determination of iron(II), Formula: C11H10N4, the publication is Boletin de la Sociedad Quimica del Peru (1980), 46(3), 278-8, database is CAplus.

Fe(II) 3-10 ppm in aqueous solution was determined spectrophotometrically by reaction with 10 mL 2 × 10^-3M 2-pyridylaldehyde 2-pyridylhydrazone in the presence of 5mL pH 9 NH₄Cl-NH₄OH buffer. The order of reagent addition is not important. The maximum absorption of the violet solution is at 550 nm. The complex is stable for at least 3 h. Stoichiometry of the complex is 2:1 (reagent/cation). Beer’s law is obeyed for 2-16 ppm Fe(II). Zr(IV) and Be(II) >50 ppm and Sn(II), Co(II), and Ce(II) >2 ppm interfere.

Boletin de la Sociedad Quimica del Peru published new progress about 2215-33-0. 2215-33-0 belongs to pyridine-derivatives, auxiliary class Pyridine,Amine, name is 2-((2-(Pyridin-2-yl)hydrazono)methyl)pyridine, and the molecular formula is C11H10N4, Formula: C11H10N4.

Referemce:
https://en.wikipedia.org/wiki/Pyridine,
Pyridine | C5H5N – PubChem

Gimenez Plaza, J. published the artcile2-Pyridinecarboxaldehyde 2-pyridylhydrazone as analytical agent. IV. Spectrophotometric determination of palladium(II), Recommanded Product: 2-((2-(Pyridin-2-yl)hydrazono)methyl)pyridine, the publication is Afinidad (1980), 37(367), 237-9, database is CAplus.

Pd(II) was determined spectrophotometrically as its 1:1 complex with 2-pyridinecarboxaldehyde 2-pyridylhydrazone. Approx. 5 mL 0.002M 2-pyridinecarboxaldehyde 2-pyridylhydrazone and 5 mL HOAc/NaOAc buffer (pH5) were added to the sample in a total volume of 25 mL. The absorbance of the solution was measured at 360-390 nm after 1 h. The relative error in the determination of 2.5-7 ppm Pd was 0.3-0.5%. Significant interference was caused by � ppm Ag(I), Cu(II), Co(II), Sn(II), Ni(II), Fe(II), Fe(III), V(V), and Au(III).

Afinidad published new progress about 2215-33-0. 2215-33-0 belongs to pyridine-derivatives, auxiliary class Pyridine,Amine, name is 2-((2-(Pyridin-2-yl)hydrazono)methyl)pyridine, and the molecular formula is C11H10N4, Recommanded Product: 2-((2-(Pyridin-2-yl)hydrazono)methyl)pyridine.

Referemce:
https://en.wikipedia.org/wiki/Pyridine,
Pyridine | C5H5N – PubChem

Gimenez Plaza, J. published the artcile2-Pyridylaldehyde-2-pyridylhydrazone as an analysis reagent. II. Spectrophotometric determination of nickel(II), COA of Formula: C11H10N4, the publication is Revista de la Sociedad Quimica de Mexico (1981), 25(4), 488-91, database is CAplus.

Ni²⁺ reacts with 2-pyridylaldehyde-2-pyridylhydrazide to form a yellow 1:1 complex which has maximum absorbance at 355 nm and pH 7.5. The color is stable up to 3 h when the order of addition is reagent + cation + buffer. Beer’s law is obeyed for 1-7 ppm Ni. Ag, Hg(II), Sb(III), Sn(II), Fe(II), Fe(III), Al, Co(II), Zn, Mn(II), Pd(II), Be, Cu(II), Cd, Au(III), Bi, Ce(IV), Ca, Sr, Ba, and Mg 2 ppm interfere.

Revista de la Sociedad Quimica de Mexico published new progress about 2215-33-0. 2215-33-0 belongs to pyridine-derivatives, auxiliary class Pyridine,Amine, name is 2-((2-(Pyridin-2-yl)hydrazono)methyl)pyridine, and the molecular formula is C11H10N4, COA of Formula: C11H10N4.

Referemce:
https://en.wikipedia.org/wiki/Pyridine,
Pyridine | C5H5N – PubChem

Empel, Anna published the artcileTowards Property Profiling: SYNTHESIS and SAR Probing of New Tetracyclic Diazaphenothiazine Analogues, Synthetic Route of 39856-58-1, the publication is International Journal of Molecular Sciences (2021), 22(23), 12826, database is CAplus and MEDLINE.

A series of new tertiary phenothiazine derivatives containing a quinoline and a pyridine fragment was synthesized by the reaction of 1-methyl-3-benzoylthio-4-butylthioquinolinium chloride with 3-aminopyridine derivatives bearing various substituents on the pyridine ring. The direction and mechanism of the cyclization reaction of intermediates with the structure of 1-methyl-4-(3-pyridyl)aminoquinolinium-3-thiolate was related to the substituents in the 2- and 4-pyridine position. The structures of the compounds were analyzed using 1H, 13C NMR (COSY, HSQC, HMBC) and X-ray anal., resp. Moreover, the antiproliferative activity against tumor cells (A549, T47D, SNB-19) and a normal cell line (NHDF) was tested. The antibacterial screening of all the compounds was conducted against the reference and quality control strain Staphylococcus aureus ATCC 29213, three clin. isolates of methicillin-resistant S. aureus (MRSA). In silico computation of the intermol. similarity was performed using principal component anal. (PCA) and hierarchical clustering anal. (HCA) on the pool of structure/property-related descriptors calculated for the novel tetracyclic diazaphenothiazine derivatives The distance-oriented property evaluation was correlated with the exptl. anticancer activities and empirical lipophilicity as well. The quant. shape-based comparison was conducted using the CoMSA method in order to indicate the potentially valid steric, electronic and lipophilic properties. Finally, the numerical sampling of similarity-related activity landscape (SALI) provided a subtle picture of the SAR trends.

International Journal of Molecular Sciences published new progress about 39856-58-1. 39856-58-1 belongs to pyridine-derivatives, auxiliary class Pyridine,Bromide,Amine, name is 2-Bromopyridin-3-amine, and the molecular formula is C5H5BrN2, Synthetic Route of 39856-58-1.

Referemce:
https://en.wikipedia.org/wiki/Pyridine,
Pyridine | C5H5N – PubChem

Berseneva, V. S. published the artcileSynthesis and properties of [(thiocarbamoyl)methyl]pyridinium (isoquinolinium) ylides, Name: 1-(Cyanomethyl)pyridin-1-ium chloride, the publication is Khimiya Geterotsiklicheskikh Soedinenii (1989), 1639-43, database is CAplus.

Treating pyridinium or isoquinolinium ylides I (R = CN) with H₂S in EtOH containing NaOEt gave ylides I (R = CSNH₂). The isoquinoline derivatives were cyclized by 1-chloro-2,4-dinitrobenzene to give 32% imidazoloisoquinoline II. Addnl. obtained from I were 15 and 30% imidazolopyridine and isoquinolines III, resp.

Khimiya Geterotsiklicheskikh Soedinenii published new progress about 17281-59-3. 17281-59-3 belongs to pyridine-derivatives, auxiliary class Pyridine,Nitrile,Salt, name is 1-(Cyanomethyl)pyridin-1-ium chloride, and the molecular formula is C7H7ClN2, Name: 1-(Cyanomethyl)pyridin-1-ium chloride.

Referemce:
https://en.wikipedia.org/wiki/Pyridine,
Pyridine | C5H5N – PubChem

Ghalehshahi, Hajar G. published the artcileSynthesis, CYP 450 evaluation, and docking simulation of novel 4-aminopyridine and coumarin derivatives, Recommanded Product: 1-(Cyanomethyl)pyridin-1-ium chloride, the publication is Archiv der Pharmazie (Weinheim, Germany) (2019), 352(3), n/a, database is CAplus and MEDLINE.

Four series of novel compounds based on 4-aminopyridine, glatiramer acetate, pyrone, and coumarin backbones were sufficiently synthesized and identified by spectroscopic methods. CYP enzyme inhibition assays of five predominate human P 450 isoenzymes indicate that all compounds, except for 4-hydrazide pyridine 1c, seem to be less toxic than 4-aminopyridine. Further investigation of the compounds using mol. docking experiments revealed different, the same, or stronger binding modes for most of the synthesized compounds, with both polar and hydrophobic interactions with the 1WDA and 1J95 receptors compared to benzoyl L-arginine amide and 4-aminopyridine, resp. These results introduce the synthesized compounds as K⁺ channel blockers that could be considered for in vivo CNS disease studies.

Archiv der Pharmazie (Weinheim, Germany) published new progress about 17281-59-3. 17281-59-3 belongs to pyridine-derivatives, auxiliary class Pyridine,Nitrile,Salt, name is 1-(Cyanomethyl)pyridin-1-ium chloride, and the molecular formula is C7H7ClN2, Recommanded Product: 1-(Cyanomethyl)pyridin-1-ium chloride.

Referemce:
https://en.wikipedia.org/wiki/Pyridine,
Pyridine | C5H5N – PubChem

Manley, Peter J. published the artcile2,4-Disubstituted pyrimidines: A novel class of KDR kinase inhibitors, Safety of 4-Amino-2-picoline, the publication is Bioorganic & Medicinal Chemistry Letters (2003), 13(10), 1673-1677, database is CAplus and MEDLINE.

2,4-Disubstituted pyrimidines were synthesized as a novel class of KDR kinase inhibitors. Evaluation of the SAR of the screening lead compound I (R = H) (KDR IC₅₀=105 nM, Cell IC₅₀=8% inhibition at 500 nM) led to the potent 3,5-dimethylaniline derivative I (R = Me) (KDR IC₅₀=6 nM, cell IC₅₀=19 nM).

Bioorganic & Medicinal Chemistry Letters published new progress about 18437-58-6. 18437-58-6 belongs to pyridine-derivatives, auxiliary class Pyridine,Amine, name is 4-Amino-2-picoline, and the molecular formula is C6H8N2, Safety of 4-Amino-2-picoline.

Referemce:
https://en.wikipedia.org/wiki/Pyridine,
Pyridine | C5H5N – PubChem

Yang, Christine published the artcileDiscovery of Benzimidazole Oxazolidinediones as Novel and Selective Nonsteroidal Mineralocorticoid Receptor Antagonists, Safety of 2-Pyridinylboronic acid, the publication is ACS Medicinal Chemistry Letters (2015), 6(4), 461-465, database is CAplus and MEDLINE.

Elaboration of the oxazolidinedione series led to replacement of the exocyclic amides with substituted benzimidazoles. The structure-activity relationship exploration resulted in the discovery of potent and selective nonsteroidal mineralocorticoid receptor antagonists with significantly improved microsomal stability and pharmacokinetic profile relative to the HTS hit. One compound I possessed comparable efficacy as spironolactone at 100 mg/kg (p.o.) in the rat natriuresis model. As such, this series was validated as a lead series for further optimization.

ACS Medicinal Chemistry Letters published new progress about 197958-29-5. 197958-29-5 belongs to pyridine-derivatives, auxiliary class Pyridine,Boronic acid and ester, name is 2-Pyridinylboronic acid, and the molecular formula is C19H14Cl2, Safety of 2-Pyridinylboronic acid.

Referemce:
https://en.wikipedia.org/wiki/Pyridine,
Pyridine | C5H5N – PubChem

Romagnoli, Romeo published the artcileSynthesis and biological evaluation of novel 2-amino-3-aroyl-4-neopentyl-5-substituted thiophene derivatives as allosteric enhancers of the A₁ adenosine receptor, Application In Synthesis of 197958-29-5, the publication is Bioorganic & Medicinal Chemistry (2014), 22(1), 148-166, database is CAplus and MEDLINE.

2-Amino-3-benzoyl thiophenes have been widely reported to act as allosteric enhancers at the A₁ adenosine receptor. Their activity can be increased considerably by appropriate substitutions at the 4- and 5-positions of the thiophene ring. Substituent size at the thiophene C-4 position seemed to be a factor closely related to activity, with the 4-neopentyl (2,2-dimethylpropyl) substitution showing the greatest enhanced activity. A wide series of 2-amino-3-aroyl-4-neopentylthiophene derivatives with general structure I, characterized by the presence of different substituents (bromine, aryl and heteroaryl) at the 5-position of the thiophene ring, have been identified as potent AEs at the A₁AR. With only one exception, all of the synthesized compounds proved to be superior to the reference compound PD 81,723 in a functional assay. Derivatives I (R = Ph, R¹ = 4-Me; R = 4-OMePh, R¹ = 4-Me; R = 3-OMePh, R¹ = 4-Cl; R = 3,4-(O-CH₂-O)Ph, R¹ = 4-Cl; and R = 4-MePh, R¹ = 4-Cl) were the most active compounds in binding (saturation and competition) and functional cAMP studies, being able to potentiate agonist [³H]CCPA binding to the A₁ receptor.

Bioorganic & Medicinal Chemistry published new progress about 197958-29-5. 197958-29-5 belongs to pyridine-derivatives, auxiliary class Pyridine,Boronic acid and ester, name is 2-Pyridinylboronic acid, and the molecular formula is C5H6BNO2, Application In Synthesis of 197958-29-5.

Referemce:
https://en.wikipedia.org/wiki/Pyridine,
Pyridine | C5H5N – PubChem

Zipp, G. Greg published the artcileNovel inhibitors of the high-affinity L-proline transporter as potential therapeutic agents for the treatment of cognitive disorders, Computed Properties of 197958-29-5, the publication is Bioorganic & Medicinal Chemistry Letters (2014), 24(16), 3886-3890, database is CAplus and MEDLINE.

The incidence of cognitive disorders such as Alzheimer’s disease continues to increase unabated. While cures for such diseases have eluded investigators, progress is being made on alleviating certain symptoms of these diseases. Mouse knockouts of the proline transporter (PROT), a high affinity Na⁺/Cl^–-dependent transporter, indicated its potential as a novel therapeutic target for cognition improvement. Herein we report our investigation into a novel class of PROT inhibitors.

Bioorganic & Medicinal Chemistry Letters published new progress about 197958-29-5. 197958-29-5 belongs to pyridine-derivatives, auxiliary class Pyridine,Boronic acid and ester, name is 2-Pyridinylboronic acid, and the molecular formula is C11H10O, Computed Properties of 197958-29-5.

Referemce:
https://en.wikipedia.org/wiki/Pyridine,
Pyridine | C5H5N – PubChem