Category: pyridine-derivatives

Storz, Thomas published the artcileThe first practical and efficient one-pot synthesis of 6-substituted 7-azaindoles via a Reissert-Henze reaction, COA of Formula: C14H12N2O, the publication is Synthesis (2008), 201-214, database is CAplus.

A variety of 6-substituted 7-azaindoles (30 examples) were obtained via selective O-methylation of 7-azaindole-N-oxide m-chlorobenzoic acid salt and subsequent, base-catalyzed one-pot reaction with a range of N-, O-, S-nucleophiles or cyanide.

Synthesis published new progress about 1018441-04-7. 1018441-04-7 belongs to pyridine-derivatives, auxiliary class 5.6_Aromatics,Pyrrolo[n,m-x]Pyridine, name is 6-(Benzyloxy)-1H-pyrrolo[2,3-b]pyridine, and the molecular formula is C18H34N4O5S, COA of Formula: C14H12N2O.

Referemce:
https://en.wikipedia.org/wiki/Pyridine,
Pyridine | C5H5N – PubChem

Siddle, Jamie S. published the artcileDivergent synthesis of arylated pyridin-2(1H)-one derivatives via metal-catalysed cross-coupling processes, Formula: C5H5BrN2, the publication is Tetrahedron (2010), 66(32), 6138-6149, database is CAplus.

1,5-Di(hetero)arylated-pyridin-2(1H)-one derivatives, e.g. I, have been readily obtained in good yields starting from 2-fluoro-5-pyridylboronic acid. The sequence comprises three steps: (i) palladium-catalyzed Suzuki-Miyaura reaction; (ii) base-catalyzed hydrolysis; (iii) copper-catalyzed C-N coupling. X-ray crystal structures are reported for selected pyridin-2(1H)-one derivatives These compounds are of interest as new scaffolds for drug discovery.

Tetrahedron published new progress about 39856-58-1. 39856-58-1 belongs to pyridine-derivatives, auxiliary class Pyridine,Bromide,Amine, name is 2-Bromopyridin-3-amine, and the molecular formula is C10H2F12NiO4, Formula: C5H5BrN2.

Referemce:
https://en.wikipedia.org/wiki/Pyridine,
Pyridine | C5H5N – PubChem

Mushrush, George W. published the artcileChemical basis of middle-distillate fuel instability – interactive effects of selected nitrogen heterocycles with organic acids and bases in a shale-derived diesel fuel, Formula: C5H5NO3S, the publication is Oil Shale Symposium Proceedings (1991), 74-81, database is CAplus.

Fuel-instability reactions with increasing time in storage usually are defined in terms of the formation of deleterious products, such as filterable sediment and peroxides. These detrimental products of long-term storage continue to be a problem in the utilization of middle-distillate fuels. Gravimetric stability tests have been carried out at 80° by using 2 model N heterocycles: 2,5-dimethylpyrrole (DMP) and 3-methylindole (3-MI) in an otherwise stable shale-derived diesel fuel. Potential interactive effects for these N heterocycles in this stable middle-distillate fuel have been described by the presence of organic acid and base co-dopants. Organic acid co-dopants included hexanoic acid, acetic acid, dodecylbenzene sulfonic acid, and p-toluene sulfonic acid; organic bases employed included tri-n-butylamine, N,N-di-Me aniline, and 4-dimethylamino pyridine. Co-dopants were selected on the number of polar species present in a shale-derived diesel fuel. The fuel matrix containing the co-dopants, 2,5-dimethylpyrrole and dodecylbenzene sulfonic acid, generated the largest quantity of filterable sediment yet observed in any of the stability tests. Simple organic amines exerted only minor interactive effects, usually an increase in filterable sediment of 5-15%. However, the diamine species, 4-dimethylamino pyridine, interacted in a strongly pos. fashion to generate increased amounts of sediment. Hydroperoxide levels were monitored for each reaction mixture Co-dopants had a drastic beneficial effect on observed hydroperoxide concentration

Oil Shale Symposium Proceedings published new progress about 636-73-7. 636-73-7 belongs to pyridine-derivatives, auxiliary class Pyridine,Sulfonic acid, name is Pyridine-3-sulfonic acid, and the molecular formula is C5H5NO3S, Formula: C5H5NO3S.

Referemce:
https://en.wikipedia.org/wiki/Pyridine,
Pyridine | C5H5N – PubChem

Guay, Daniel published the artcileSynthesis and SAR of pyrimidine-based, non-nucleotide P2Y₁₄ receptor antagonists, SDS of cas: 197958-29-5, the publication is Bioorganic & Medicinal Chemistry Letters (2011), 21(10), 2832-2835, database is CAplus and MEDLINE.

A weak antagonist of the pyrimidinergic receptor P2Y₁₄ containing a dihydropyridopyrimidine core was identified through high-throughput screening. Subsequent optimization led to potent, non-UTP competitive antagonists and represent the first reported non-nucleotide antagonists of this receptor. Dihydropyridopyrimidine I was identified as a 10 nM P2Y₁₄ antagonist with good oral bioavailability and provided sufficient exposure in mice to be used as a tool for future in vivo studies.

Bioorganic & Medicinal Chemistry Letters published new progress about 197958-29-5. 197958-29-5 belongs to pyridine-derivatives, auxiliary class Pyridine,Boronic acid and ester, name is 2-Pyridinylboronic acid, and the molecular formula is C5H6BNO2, SDS of cas: 197958-29-5.

Referemce:
https://en.wikipedia.org/wiki/Pyridine,
Pyridine | C5H5N – PubChem

Baus Topic, Nea published the artcileHalogen-Bonded Cocrystals of 1,3,5-Triiodo-2,4,6-trifluorobenzene and Structural Isomers of Benzoylpyridine, Computed Properties of 91-02-1, the publication is Crystal Growth & Design (2022), 22(6), 3981-3989, database is CAplus.

Six novel halogen-bonded cocrystals of 1,3,5-triiodo-2,4,6-trifluorobenzene with three structural isomers of benzoylpyridine have been synthesized mechanochem. and by crystallization from solution, five of which were structurally characterized. In four cocrystals, benzoylpyridine is a ditopic halogen-bond acceptor participating in halogen bonding with both pyridine nitrogen and carbonyl oxygen atoms, while in one cocrystal, only the I···N halogen bond has formed. In general, the I···N halogen bonds are shorter than I···O interactions, except in the cocrystals with 2-benzoylpyridine. The N and O halogen-bond acceptor sites were evaluated using calculated mol. electrostatic potentials (MEPs) and binding energies of both I···N and I···O halogen-bonded dimers in the gas phase.

Crystal Growth & Design published new progress about 91-02-1. 91-02-1 belongs to pyridine-derivatives, auxiliary class Pyridine,Benzene,Ketone, name is Phenyl(pyridin-2-yl)methanone, and the molecular formula is C12H9NO, Computed Properties of 91-02-1.

Referemce:
https://en.wikipedia.org/wiki/Pyridine,
Pyridine | C5H5N – PubChem

Rozatian, Neshat published the artcileEnolization rates control mono- versus di-fluorination of 1,3-dicarbonyl derivatives, Recommanded Product: 1-Fluoropyridiniumtriflate, the publication is Chemical Science (2019), 10(44), 10318-10330, database is CAplus and MEDLINE.

Fluorine-containing 1,3-dicarbonyl derivatives are essential building blocks for drug discovery and manufacture To understand the factors that determine selectivity between mono- and di-fluorination of 1,3-dicarbonyl systems, we have performed kinetic studies of keto-enol tautomerism and fluorination processes. Photoketonization of 1,3-diaryl-1,3-dicarbonyl derivatives and their 2-fluoro analogs is coupled with relaxation kinetics to determine enolization rates. Reaction additives such as water accelerate enolization processes, especially of 2-fluoro-1,3-dicarbonyl systems. Kinetic studies of enol fluorination with Selectfluor and NFSI reveal the quant. effects of 2-fluorination upon enol nucleophilicity towards reagents of markedly different electrophilicity. Our findings have important implications for the synthesis of α,α-difluoroketonic compounds, providing valuable quant. information to aid in the design of fluorination and difluorination reactions.

Chemical Science published new progress about 107263-95-6. 107263-95-6 belongs to pyridine-derivatives, auxiliary class Fluorination reagent, name is 1-Fluoropyridiniumtriflate, and the molecular formula is C6H5F4NO3S, Recommanded Product: 1-Fluoropyridiniumtriflate.

Referemce:
https://en.wikipedia.org/wiki/Pyridine,
Pyridine | C5H5N – PubChem

Oliveira, Isabel B. published the artcileAcute toxicity of tralopyril, capsaicin and triphenylborane pyridine to marine invertebrates, Safety of Triphenyl(pyridin-1-ium-1-yl)borate, the publication is Ecotoxicology (2014), 23(7), 1336-1344, database is CAplus and MEDLINE.

A need for environmentally acceptable alternative antifouling (AF) biocides has arisen through restrictions in the use of many common biocides in the European Union through the Biocidal Product Regulation (Regulation EU Number 528/2012). Three such alternatives are triphenylborane pyridine (TPBP), tralopyril and capsaicin. This study aims at extending the available information on the toxicity of these three emerging AF biocides to key marine invertebrates. Here we investigate the toxicity of tralopyril and capsaicin to the early life stages of the mussel Mytilus galloprovincialis and the sea urchin Paracentrotus lividus and also of tralopyril, capsaicin and TPBP to the early life stages of the copepod Tisbe battagliai. The EC₅₀ that causes abnormal development of mussel’s D-veliger larvae and impairs the growth of sea urchin pluteus larvae are resp. 3.1 and 3.0 μg/L for tralopyril and 3,868 and 5,248 μg/L for capsaicin. Regarding the copepod T. battagliai, the LC₅₀ was 0.9 μg/L for tralopyril, 1,252 μg/L for capsaicin and 14 μg/L for TPBP. The results obtained for the three substances are compared to a reference AF biocide, tributyltin (TBT), and their ecol. risk evaluated. These compounds pose a lower environmental risk than TBT but still, our results suggest that tralopyril and TPBP may represent a considerable threat to the ecosystems.

Ecotoxicology published new progress about 971-66-4. 971-66-4 belongs to pyridine-derivatives, auxiliary class Pyridine,Benzene, name is Triphenyl(pyridin-1-ium-1-yl)borate, and the molecular formula is C23H20BN, Safety of Triphenyl(pyridin-1-ium-1-yl)borate.

Referemce:
https://en.wikipedia.org/wiki/Pyridine,
Pyridine | C5H5N – PubChem

Quddus, M. A. published the artcileExtraction of zinc by pyridine 2-carboxaldehyde 2-pyridylhydrazone (PAPHY) in chloroform, SDS of cas: 2215-33-0, the publication is Journal of Inorganic and Nuclear Chemistry (1971), 33(7), 2001-7, database is CAplus.

The distribution of Zn between aqueous solutions and pyridine 2-carboxaldehyde 2-pyridylhydrazone (PAPHY) in CHCl3 has been studied as a function of the pH of the aqueous phase and the concentration of PAPHY. Stability and acid dissociation constants of the complex ions have been determined as well as the partition coefficients of the ligand and its extractable Zn complex. An equation has been proposed to represent the extraction equilibrium and its essential correctness verified.

Journal of Inorganic and Nuclear Chemistry published new progress about 2215-33-0. 2215-33-0 belongs to pyridine-derivatives, auxiliary class Pyridine,Amine, name is 2-((2-(Pyridin-2-yl)hydrazono)methyl)pyridine, and the molecular formula is C11H10N4, SDS of cas: 2215-33-0.

Referemce:
https://en.wikipedia.org/wiki/Pyridine,
Pyridine | C5H5N – PubChem

Feller, Moran published the artcileMononuclear Rh(II) PNP-Type Complexes. Structure and Reactivity, Product Details of C23H43NP2, the publication is Inorganic Chemistry (2007), 46(25), 10479-10490, database is CAplus and MEDLINE.

The Rh(II) mononuclear complexes [(PNP^tBu)RhCl][BF₄] (2), [(PNP^tBu)Rh(OC(O)CF₃)] (4), and [(PNP^t-Bu)Rh(acetone)][BF₄]₂ (6), where PNP^tBu = 2,6-bis(di-tert-butylphosphinomethyl)pyridine, were synthesized by oxidation of the corresponding Rh(I) analogs with silver salts. However, treatment of (PNP^tBu)RhCl with AgOC(O)CF₃ led only to chloride abstraction, with no oxidation 2 And 6 were characterized by x-ray diffraction, EPR, cyclic voltammetry, and dipole moment measurements. 2 And 6 react with NO gas to give diamagnetic [(PNP^tBu)Rh(NO)Cl][BF₄] (7) and [(PNP^tBu)Rh(NO)(acetone)][BF₄]₂ (8), resp. 6 Is reduced to Rh(I) in the presence of phosphines, CO, or isonitriles to give the Rh(I) complexes [(PNP^tBu)Rh(PR₃)][BF₄] (11, 12) (R = t, Ph), [(PNP^tBu)Rh(CO)][BF₄] (13) and [(PNP^tBu)Rh(L)][BF₄] (15, 16) (L = tert-Bu isonitrile or 2,6-dimethylphenyl isonitrile), resp. However, 2 disproportionates to Rh(I) and Rh(III) complexes in the presence of acetonitrile, or CO. 2 Is also reduced by triethylphosphine and water to Rh(I) complexes [(PNP^tBu)RhCI] (1) and [(PNP^tBu)Rh(PEt₃)][BF₄] (11). When triphenylphosphine and water were used, the reduced Rh(I) complex reacts with a proton, which is formed in the redox reaction to give a Rh(III) complex with a coordinated BF₄, [(PNP^tBu)Rh(Cl)(H)(BF₄)] (9).

Inorganic Chemistry published new progress about 338800-13-8. 338800-13-8 belongs to pyridine-derivatives, auxiliary class Bis-phosphine Ligands, name is 2,6-Bis((di-tert-butylphosphino)methyl)pyridine, and the molecular formula is C23H43NP2, Product Details of C23H43NP2.

Referemce:
https://en.wikipedia.org/wiki/Pyridine,
Pyridine | C5H5N – PubChem

Feller, Moran published the artcileCationic, Neutral, and Anionic PNP Pd^II and Pt^II Complexes: Dearomatization by Deprotonation and Double-Deprotonation of Pincer Systems, Synthetic Route of 338800-13-8, the publication is Inorganic Chemistry (2010), 49(4), 1615-1625, database is CAplus and MEDLINE.

Cationic, neutral, and anionic Pd^II and Pt^II PNP (PNP = 2,6-bis(di-tert-butylphosphinomethyl)pyridine) complexes were synthesized. The neutral, dearomatized complexes [(PNP^*)MX] (PNP^* = deprotonated PNP; M = Pd, Pt; X = Cl, Me) were prepared by deprotonation of the PNP methylene group of the corresponding cationic complexes [(PNP)MX][Cl] with 1 equiv of base (KN(SiMe₃)₂ or ^tBuOK), while the anionic complexes [(PNP^**)MX]^–Y⁺ (PNP^** = double-deprotonated PNP; Y = Li, K) were prepared by deprotonation of the two methylene groups of the corresponding cationic complexes with either 2 equiv of KN(SiMe₃)₂ or an excess of MeLi. While the reaction of [(PNP)PtCl][Cl] with an excess of MeLi led only to the anionic complex without chloride substitution, reaction of [(PNP)PdCl][Cl] with an excess of MeLi led to the methylated anionic complex [(PNP^**)PdMe]^–Li⁺. NMR studies, x-ray structures, and d. functional theory (DFT) calculations reveal that the neutral complexes have a broken aromatic system with alternating single and double bonds, and the deprotonated arm is bound to the ring by an exocyclic C:C double bond. The anionic complexes are best described as a π system comprising the ring carbons conjugated with the exocyclic double bonds of the deprotonated arms. The neutral complexes are reversibly protonated to their cationic analogs by H₂O or MeOH. The thermodn. parameters ΔH, ΔS, and ΔG for the reversible protonation of the neutral complexes by MeOH were obtained.

Inorganic Chemistry published new progress about 338800-13-8. 338800-13-8 belongs to pyridine-derivatives, auxiliary class Bis-phosphine Ligands, name is 2,6-Bis((di-tert-butylphosphino)methyl)pyridine, and the molecular formula is C23H43NP2, Synthetic Route of 338800-13-8.

Referemce:
https://en.wikipedia.org/wiki/Pyridine,
Pyridine | C5H5N – PubChem