Category: pyridine-derivatives

Li, Liping team published research in Organic Letters in 2020 | 16133-25-8

16133-25-8, Pyridine-3-sulfonyl chloride is a useful research compound. Its molecular formula is C5H4ClNO2S and its molecular weight is 177.61 g/mol. The purity is usually 95%.
Pyridine-3-sulfonyl chloride is a reagent used in the synthesis of pyrimidine derivatives with anti-proliferative activity against negative breast cancer cells.
Pyridine-3-sulfonyl chloride is a chemical compound that binds to the active site of cytochrome P450 enzymes. It can be used to study the effects of matrix effect on reaction solution. Pyridine-3-sulfonyl chloride has been shown to have an UV absorption spectrum with a maximum at 280 nm and a p450 activity that is proportional to the concentration of human serum. This compound has been shown to inhibit kinase domain in vitro assays, which may have clinical relevance in the treatment of obesity., Application of C5H4ClNO2S

Pyridine has a conjugated system of six π electrons that are delocalized over the ring. 16133-25-8, formula is C5H4ClNO2S, Name is Pyridine-3-sulfonyl chloride. The molecule is planar and, thus, follows the Hückel criteria for aromatic systems. Application of C5H4ClNO2S.

Li, Liping;Gao, Hui;Sun, Ming;Zhou, Zhi;Yi, Wei research published 《 Experimental and Computational Studies on Cp*CyRh(III)/KOPiv-Catalyzed Intramolecular Dehydrogenative Cross-Couplings for Building Eight-Membered Sultam/Lactam Frameworks》, the research content is summarized as follows. Described herein is an unusual Cp*CyRh(III)-catalyzed intramol. site-specific aryl C-H annulation, a highly chemoselective protocol providing direct access to eight-membered sultams/lactams I (R1 = H, 9-Me, 7-Cl, etc; R2 = Me, Et, Ph, 4-Br-C6H4; R3 = H, 2-Me, 3-OMe, etc.)and II (X = CO, PO-Ph; Ar = Ph, 2-Me-C6H4, Naph, Py, etc.) with broad substrate/functional group tolerance. Exptl. and computational studies reveal that such a transformation involves a unique PivOH-assisted aryl C-H activation/alkene insertion/β-H elimination/hydrogen-transfer process involving the Rh(III)-hydride species as the active intermediate with the concomitant release of H2 as the major byproduct, thus enabling the developed Cp*CyRh(III) catalysis with redox-neutral and highly atom-economical features.

16133-25-8, Pyridine-3-sulfonyl chloride is a useful research compound. Its molecular formula is C5H4ClNO2S and its molecular weight is 177.61 g/mol. The purity is usually 95%.
Pyridine-3-sulfonyl chloride is a reagent used in the synthesis of pyrimidine derivatives with anti-proliferative activity against negative breast cancer cells.
Pyridine-3-sulfonyl chloride is a chemical compound that binds to the active site of cytochrome P450 enzymes. It can be used to study the effects of matrix effect on reaction solution. Pyridine-3-sulfonyl chloride has been shown to have an UV absorption spectrum with a maximum at 280 nm and a p450 activity that is proportional to the concentration of human serum. This compound has been shown to inhibit kinase domain in vitro assays, which may have clinical relevance in the treatment of obesity., Application of C5H4ClNO2S

Referemce:
Pyridine – Wikipedia,
Pyridine | C5H5N – PubChem

Li, Long team published research in Angewandte Chemie, International Edition in 2020 | 31181-90-5

31181-90-5, 5-Bromopyridine-2-carbaldehyde is a useful research compound. Its molecular formula is C6H4BrNO and its molecular weight is 186.01 g/mol. The purity is usually 95%.

5-Bromopyridine-2-carbaldehyde is a water soluble organic molecule that has been shown to inhibit the mitochondrial respiratory chain. It is a structural analog of the natural substrate for mitochondrial cytochrome c oxidase, 5-aminolevulinic acid. This compound has been shown to be selective against cancer cells and has anti-viral properties. The photophysical properties of 5-bromopyridine-2-carbaldehyde have been studied extensively. The fluorescence quantum yield of this molecule in aqueous solution is 0.06%., SDS of cas: 31181-90-5

Pyridine is colorless, but older or impure samples can appear yellow. 31181-90-5, formula is C6H4BrNO, Name is 5-Bromopicolinaldehyde. The pyridine ring occurs in many important compounds, including agrochemicals, pharmaceuticals, and vitamins. Historically, pyridine was produced from coal tar. SDS of cas: 31181-90-5.

Li, Long;Han, Feng;Nie, Xin;Hong, Yubiao;Ivlev, Sergei;Meggers, Eric research published 《 Complementing Pyridine-2,6-bis(oxazoline) with Cyclometalated N-Heterocyclic Carbene for Asymmetric Ruthenium Catalysis》, the research content is summarized as follows. A strategy for expanding the utility of chiral pyridine-2,6-bis(oxazoline) (pybox) ligands for asym. transition metal catalysis is introduced by adding a bidentate ligand to modulate the electronic properties and asym. induction. Specifically, a ruthenium(II) pybox fragment is combined with a cyclometalated N-heterocyclic carbene (NHC) ligand to generate catalysts for enantioselective transition metal nitrenoid chem., including ring contraction to chiral 2H-azirines (up to 97% ee with 2000 TON) and enantioselective C(sp3)-H aminations (up to 97% ee with 50 TON).

31181-90-5, 5-Bromopyridine-2-carbaldehyde is a useful research compound. Its molecular formula is C6H4BrNO and its molecular weight is 186.01 g/mol. The purity is usually 95%.

5-Bromopyridine-2-carbaldehyde is a water soluble organic molecule that has been shown to inhibit the mitochondrial respiratory chain. It is a structural analog of the natural substrate for mitochondrial cytochrome c oxidase, 5-aminolevulinic acid. This compound has been shown to be selective against cancer cells and has anti-viral properties. The photophysical properties of 5-bromopyridine-2-carbaldehyde have been studied extensively. The fluorescence quantum yield of this molecule in aqueous solution is 0.06%., SDS of cas: 31181-90-5

Referemce:
Pyridine – Wikipedia,
Pyridine | C5H5N – PubChem

Li, Peng team published research in European Journal of Medicinal Chemistry in 2021 | 16133-25-8

COA of Formula: C5H4ClNO2S, Pyridine-3-sulfonyl chloride is a useful research compound. Its molecular formula is C5H4ClNO2S and its molecular weight is 177.61 g/mol. The purity is usually 95%.
Pyridine-3-sulfonyl chloride is a reagent used in the synthesis of pyrimidine derivatives with anti-proliferative activity against negative breast cancer cells.
Pyridine-3-sulfonyl chloride is a chemical compound that binds to the active site of cytochrome P450 enzymes. It can be used to study the effects of matrix effect on reaction solution. Pyridine-3-sulfonyl chloride has been shown to have an UV absorption spectrum with a maximum at 280 nm and a p450 activity that is proportional to the concentration of human serum. This compound has been shown to inhibit kinase domain in vitro assays, which may have clinical relevance in the treatment of obesity., 16133-25-8.

The critical parameters of pyridine are pressure 6.70 MPa, temperature 620 K and volume 229 cm3·mol−1. 16133-25-8, formula is C5H4ClNO2S, Name is Pyridine-3-sulfonyl chloride. In the temperature range 340–426 °C its vapor pressure p can be described with the Antoine equation.. COA of Formula: C5H4ClNO2S.

Li, Peng;Wang, Bin;Fu, Lei;Guo, Kaijing;Ma, Chen;Wang, Baolian;Lin, Ziyun;Li, Gang;Huang, Haihong;Lu, Yu research published 《 Identification of novel benzothiopyranones with ester and amide motifs derived from active metabolite as promising leads against Mycobacterium tuberculosis》, the research content is summarized as follows. We reported three distinct series of novel benzothiopyranones, derived from an active metabolite (M-1) of anti-TB agent 6b. These small mols. were evaluated for their biol. activities against a range of Mycobacterium tuberculosis (M. tuberculosis) strains. Preliminary druggability evaluation demonstrated that M-1 showed good aqueous solubility and hepatocyte stability. Benzothiopyranones with acyl, sulfonyl and phosphoryl groups exhibited potent in vitro inhibitory activity against M. tuberculosis H37Rv and low cytotoxicity. In particular, compound 3d, containing a benzoate fragment, displayed marked metabolic stability and potent in vitro activity against drug-resistant tuberculosis clin. strains. Further druggability evaluation based on the identified compounds 3d, 4e and 5b is ongoing for the discovery of promising anti-TB agents.

COA of Formula: C5H4ClNO2S, Pyridine-3-sulfonyl chloride is a useful research compound. Its molecular formula is C5H4ClNO2S and its molecular weight is 177.61 g/mol. The purity is usually 95%.
Pyridine-3-sulfonyl chloride is a reagent used in the synthesis of pyrimidine derivatives with anti-proliferative activity against negative breast cancer cells.
Pyridine-3-sulfonyl chloride is a chemical compound that binds to the active site of cytochrome P450 enzymes. It can be used to study the effects of matrix effect on reaction solution. Pyridine-3-sulfonyl chloride has been shown to have an UV absorption spectrum with a maximum at 280 nm and a p450 activity that is proportional to the concentration of human serum. This compound has been shown to inhibit kinase domain in vitro assays, which may have clinical relevance in the treatment of obesity., 16133-25-8.

Referemce:
Pyridine – Wikipedia,
Pyridine | C5H5N – PubChem

Li, Shi-Guang team published research in Journal of Organic Chemistry in 2019 | 766-11-0

766-11-0, 5-Bromo-2-fluoropyridine is a useful research compound. Its molecular formula is C5H3BrFN and its molecular weight is 175.99 g/mol. The purity is usually 95%.
5-Bromo-2-fluoropyridine is a boronic acid that has been shown to react with iodides and form 5-bromo-2-fluoroiodobenzene. The reaction of 5-bromo-2-fluoropyridine with benzene gives the same product as the reaction with 1,3,5-trioxane. The UV absorption of 5-bromo-2-fluoropyridine is found at 230 nm and 260 nm. It also has an absorption band in the infrared region at 1625 cm−1. Vibrational progressions have been observed for this molecule, which are due to dipole moments and electron density distributions in the molecule.
5-bromo-2-fluoropyridine is used in the synthesis of heteroaromatic and aniline derivatives of piperidines as potent ligands used for vesicular acetylcholine transport. , Recommanded Product: 5-Bromo-2-fluoropyridine

Pyridine is diamagnetic and has a diamagnetic susceptibility of −48.7 × 10−6 cm3·mol−1.The molecular electric dipole moment is 2.2 debyes. 766-11-0, formula is C5H3BrFN, Name is 5-Bromo-2-fluoropyridine. TThe standard enthalpy of formation is 100.2 kJ·mol−1 in the liquid phase and 140.4 kJ·mol−1 in the gas phase. Recommanded Product: 5-Bromo-2-fluoropyridine.

Li, Shi-Guang;Yuan, Minglei;Topic, Filip;Han, Zhengxu S.;Senanayake, Chris H.;Tsantrizos, Youla S. research published 《 Asymmetric Library Synthesis of P-Chiral t-Butyl-Substituted Secondary and Tertiary Phosphine Oxides》, the research content is summarized as follows. An asym. synthesis, amenable to library preparation of structurally diverse P-chiral t-Bu substituted secondary phosphine oxides (SPOs) and tertiary phosphine oxides (TPOs), was developed. A P-chiral H-phosphinate building block was prepared via a two-step, one-pot condensation of a chiral auxiliary with t-BuPCl2, followed by hydrolysis. Nucleophilic displacement of the chiral auxiliary with Grignard reagents, followed by hydrolysis, provided a library of P-chiral SPOs. In situ treatment of the prehydrolysis intermediate with electrophiles also provided a library of P-chiral TPOs in high enantiomeric purity.

766-11-0, 5-Bromo-2-fluoropyridine is a useful research compound. Its molecular formula is C5H3BrFN and its molecular weight is 175.99 g/mol. The purity is usually 95%.
5-Bromo-2-fluoropyridine is a boronic acid that has been shown to react with iodides and form 5-bromo-2-fluoroiodobenzene. The reaction of 5-bromo-2-fluoropyridine with benzene gives the same product as the reaction with 1,3,5-trioxane. The UV absorption of 5-bromo-2-fluoropyridine is found at 230 nm and 260 nm. It also has an absorption band in the infrared region at 1625 cm−1. Vibrational progressions have been observed for this molecule, which are due to dipole moments and electron density distributions in the molecule.
5-bromo-2-fluoropyridine is used in the synthesis of heteroaromatic and aniline derivatives of piperidines as potent ligands used for vesicular acetylcholine transport. , Recommanded Product: 5-Bromo-2-fluoropyridine

Referemce:
Pyridine – Wikipedia,
Pyridine | C5H5N – PubChem

Li, Yibiao team published research in Organic & Biomolecular Chemistry in 2018 | 766-11-0

766-11-0, 5-Bromo-2-fluoropyridine is a useful research compound. Its molecular formula is C5H3BrFN and its molecular weight is 175.99 g/mol. The purity is usually 95%.
5-Bromo-2-fluoropyridine is a boronic acid that has been shown to react with iodides and form 5-bromo-2-fluoroiodobenzene. The reaction of 5-bromo-2-fluoropyridine with benzene gives the same product as the reaction with 1,3,5-trioxane. The UV absorption of 5-bromo-2-fluoropyridine is found at 230 nm and 260 nm. It also has an absorption band in the infrared region at 1625 cm−1. Vibrational progressions have been observed for this molecule, which are due to dipole moments and electron density distributions in the molecule.
5-bromo-2-fluoropyridine is used in the synthesis of heteroaromatic and aniline derivatives of piperidines as potent ligands used for vesicular acetylcholine transport. , Recommanded Product: 5-Bromo-2-fluoropyridine

Pyridine has a conjugated system of six π electrons that are delocalized over the ring. 766-11-0, formula is C5H3BrFN, Name is 5-Bromo-2-fluoropyridine. The molecule is planar and, thus, follows the Hückel criteria for aromatic systems. Recommanded Product: 5-Bromo-2-fluoropyridine.

Li, Yibiao;Huang, Shuo;Liao, Chunshu;Shao, Yan;Chen, Lu research published 《 Transition-metal-free access to 2-aminopyridine derivatives from 2-fluoropyridines and acetamidine hydrochloride》, the research content is summarized as follows. An efficient method for the synthesis of 2-aminopyridine derivatives I (R = 3-I, 3-Cl-5-I, 5-NO2-6-CH3, etc.; R1 = NH2) through the nucleophilic substitution and hydrolysis of 2-fluoropyridines I (R1 = F) and acetamidine hydrochloride under catalyst-free conditions has been developed. This amination uses inexpensive acetamidine hydrochloride as the ammonia source and has the advantages of high yield, high chemoselectivity and wide substrate adaptability. The results suggest that other N-heterocycles containing fluorine substituents such as 5-chloro-2,4-difluoropyrimidine and 2-fluoropyrazine can also complete the reaction via these reaction conditions and yield the target products 5-chloro-4-fluoropyrimidin-2-amine and pyrazin-2-amine resp.

766-11-0, 5-Bromo-2-fluoropyridine is a useful research compound. Its molecular formula is C5H3BrFN and its molecular weight is 175.99 g/mol. The purity is usually 95%.
5-Bromo-2-fluoropyridine is a boronic acid that has been shown to react with iodides and form 5-bromo-2-fluoroiodobenzene. The reaction of 5-bromo-2-fluoropyridine with benzene gives the same product as the reaction with 1,3,5-trioxane. The UV absorption of 5-bromo-2-fluoropyridine is found at 230 nm and 260 nm. It also has an absorption band in the infrared region at 1625 cm−1. Vibrational progressions have been observed for this molecule, which are due to dipole moments and electron density distributions in the molecule.
5-bromo-2-fluoropyridine is used in the synthesis of heteroaromatic and aniline derivatives of piperidines as potent ligands used for vesicular acetylcholine transport. , Recommanded Product: 5-Bromo-2-fluoropyridine

Referemce:
Pyridine – Wikipedia,
Pyridine | C5H5N – PubChem

Walsh, Shawn P. et al. published their patent in 2014 |CAS: 868551-99-9

The Article related to preparation piperidine derivative inhibitor renal medullary potassium channel, cardiovascular disease piperidine derivative inhibitor renal medullary potassium channel, edema treatment piperidine derivative inhibitor renal medullary potassium channel and other aspects.Recommanded Product: 868551-99-9

On June 5, 2014, Walsh, Shawn P.; Cato, Brian; Frie, Jessica L.; Kim, Dooseop; Pasternak, Alexander; Shi, Zhi-Cai published a patent.Recommanded Product: 868551-99-9 The title of the patent was Preparation of piperidine derivatives as inhibitors of the renal outer medullary potassium channel for treating cardiovascular diseases and edematous conditions. And the patent contained the following:

The present invention provides compounds of Formula I (wherein n = 0-1; the N-containing ring system is (un)substituted piperidinyl, etc.; R1 is -H, -OC1-3alkyl or -OH; R2 is -H or C1-3alkyl; R3 is -H, -F, -C1-3 alkyl or phenyl; or when n is 0, R2 and R3 are joined together to form a 4-6 member ring with the nitrogen and carbon to which each is attached; R4 and R5 are each independently -H or -C1-3-alkyl, or R4 and R5 are joined together with the carbon to which they are attached to form C3-6 cycloalkyl; Z1 is (un)substituted Ph, (un)substituted benzofuranyl, or (un)substituted benzopyranyl, and Z2 is a substituted N-containing heterocyclyl, (un)substituted Ph, etc.), and the pharmaceutically acceptable salts thereof, which are inhibitors of the ROMK (Kir1.1) channel. The compounds may be used as diuretic and/or natriuretic agents and for the therapy and prophylaxis of medical conditions including cardiovascular diseases such as hypertension, heart failure and conditions associated with excessive salt and water retention. Synthetic procedures for preparing I are exemplified. Example compound II was prepared by reacting intermediates 1-oxo-N-(piperidin-4-yl)-1,3-dihydroisobenzofuran-5-carboxamide hydrochloride and (4-methyl-1-oxo-1,3-dihydro-2-benzofuran-5-yl)acetaldehyde. In the ROMK channel functional thallium flux assay, II had an IC50 of 0.01 μM. The experimental process involved the reaction of Methyl 5-amino-4-methylpicolinate(cas: 868551-99-9).Recommanded Product: 868551-99-9

The Article related to preparation piperidine derivative inhibitor renal medullary potassium channel, cardiovascular disease piperidine derivative inhibitor renal medullary potassium channel, edema treatment piperidine derivative inhibitor renal medullary potassium channel and other aspects.Recommanded Product: 868551-99-9

Referemce:
Pyridine – Wikipedia,
Pyridine | C5H5N – PubChem

Cuthbertson, Alan et al. published their patent in 2021 |CAS: 282734-37-6

The Article related to peptide chelator conjugate preparation antitumor prostate cancer, preparation peptide chelator thorium 227 her2 fap psma conjugate, prostate specific membrane antigen carboxy hopo thorium 227 conjugate, targeted radiopharmaceutical prostate cancer and other aspects.HPLC of Formula: 282734-37-6

On January 28, 2021, Cuthbertson, Alan; Boehnke, Niels published a patent.HPLC of Formula: 282734-37-6 The title of the patent was Targeted radiopharmaceuticals for the diagnosis and treatment of prostate cancer. And the patent contained the following:

The invention is related to the preparation of compounds I [n = 1-3; R1-4 = OH or Q; Q = a tissue-targeting moiety selected from the group consisting of poly- and oligopeptides, proteins, DNA and RNA fragments, aptamers polyclonal or monoclonal antibodies, and a mixture of proteins or fragments or constructs of protein] their stereoisomers, hydrates, solvates and salts, and targeted radiopharmaceuticals, pharmaceutical compositions and combinations comprising them and their use for manufacturing pharmaceutical compositions for the treatment or prophylaxis of diseases, in particular of soft tissue diseases, as a sole agent or in combination with other active ingredients. The experimental process involved the reaction of (S)-2-((((9H-Fluoren-9-yl)methoxy)carbonyl)amino)-3-(5-bromopyridin-2-yl)propanoic acid(cas: 282734-37-6).HPLC of Formula: 282734-37-6

The Article related to peptide chelator conjugate preparation antitumor prostate cancer, preparation peptide chelator thorium 227 her2 fap psma conjugate, prostate specific membrane antigen carboxy hopo thorium 227 conjugate, targeted radiopharmaceutical prostate cancer and other aspects.HPLC of Formula: 282734-37-6

Referemce:
Pyridine – Wikipedia,
Pyridine | C5H5N – PubChem

van Herrikhuyzen, Jeroen et al. published their research in Organic & Biomolecular Chemistry in 2006 |CAS: 75449-26-2

The Article related to oligophenylenevinylene nonracemic preparation uv visible spectra self assembly, aggregation pi stacking hydrogen bonding interaction nonracemic oligophenylenevinylene, hydrogen bonding pi interaction self assembly sym oligophenylenevinylene disk and other aspects.Quality Control of [2,2′-Bipyridine]-3,3′-diamine

On April 21, 2006, van Herrikhuyzen, Jeroen; Jonkheijm, Pascal; Schenning, Albertus P. H. J.; Meijer, E. W. published an article.Quality Control of [2,2′-Bipyridine]-3,3′-diamine The title of the article was The influence of hydrogen bonding and π-π stacking interactions on the self-assembly properties of C3-symmetrical oligo(p-phenylenevinylene) discs. And the article contained the following:

Three nonracemic C3-sym. oligophenylenevinylenes (OPV) are prepared and characterized; the UV/visible and IR spectra of the products in solution are determined and used to characterize the structures formed by self-assembly of the OPV. OPVs with triaminobenzene and benzenetricarboxamide cores show two-step transitions from helical stacks to molecularly dissolved species; the orientation of the amide relative to the core determines the stabilities and helicities of fibers in solution and the lengths of fibrils formed at surfaces. An OPV with a tris(2,2′-bipyridin-3-yl)benzenetricarboxamide core forms aggregates that show little chiral ordering but which remain present over a large temperature range; at surfaces, completely disordered structures exist as a result of competing types of π-π stacking interactions that differ in strength and orientation. The design of functional self-assembled architectures based on hydrogen bonding and π-π stacking interactions requires careful balancing of the topologies, directionalities and strengths of secondary interactions. The experimental process involved the reaction of [2,2′-Bipyridine]-3,3′-diamine(cas: 75449-26-2).Quality Control of [2,2′-Bipyridine]-3,3′-diamine

The Article related to oligophenylenevinylene nonracemic preparation uv visible spectra self assembly, aggregation pi stacking hydrogen bonding interaction nonracemic oligophenylenevinylene, hydrogen bonding pi interaction self assembly sym oligophenylenevinylene disk and other aspects.Quality Control of [2,2′-Bipyridine]-3,3′-diamine

Referemce:
Pyridine – Wikipedia,
Pyridine | C5H5N – PubChem

Alo, Babajide I. et al. published their research in Journal of Heterocyclic Chemistry in 1992 |CAS: 636-73-7

The Article related to sultone pyridine fused, sultam pyridine fused, pyridinesulfonamide directed lithiation, isothiazolopyridinone dioxide, oxathiolopyridine, aminosulfonylpyridine lithiated reaction benzophenone, intramol cyclocondensation sulfonylpyridylmethanol and other aspects.Safety of Pyridine-3-sulfonic acid

On February 29, 1992, Alo, Babajide I.; Familoni, Oluwole B.; Marsais, Francis; Queguiner, Guy published an article.Safety of Pyridine-3-sulfonic acid The title of the article was Directed metalation of pyridinesulfonamides. Synthesis of pyridine-fused isothiazoles and 1,2-oxathioles. And the article contained the following:

4-Lithio-N-tert-butylpyridine-3-sulfonamide reacted with Ph2CO or CO2 to give the corresponding intermediates, which on appropriate treatment gave the addition product I (from Ph2CO reaction product) or isothiazolo[5,4-c]pyridin-3-one 1,1-dioxides II (R = H, Me3C) (from CO2 reaction product). Metalation of 2- and 4-[N,N-(dialkylamino)sulfonyl]pyridines with LiN(CHMe2)2 gave anions which reacted with Ph2CO to give carbinols, which cyclized thermally to 1,2-oxathiolo[3,4-b]- III and -[4,3-c]pyridine dioxide IV, resp. The experimental process involved the reaction of Pyridine-3-sulfonic acid(cas: 636-73-7).Safety of Pyridine-3-sulfonic acid

The Article related to sultone pyridine fused, sultam pyridine fused, pyridinesulfonamide directed lithiation, isothiazolopyridinone dioxide, oxathiolopyridine, aminosulfonylpyridine lithiated reaction benzophenone, intramol cyclocondensation sulfonylpyridylmethanol and other aspects.Safety of Pyridine-3-sulfonic acid

Referemce:
Pyridine – Wikipedia,
Pyridine | C5H5N – PubChem

Kelly, Michael G. et al. published their patent in 2005 |CAS: 39919-70-5

The Article related to naphthyridinamine pyridopyrimidinamine preparation vanilloid receptor antagonist, ion channel ligand naphthyridinamine pyridopyrimidinamine preparation, pain inflammation traumatic injury drug naphthyridinamine pyridopyrimidinamine preparation and other aspects.Related Products of 39919-70-5

On July 21, 2005, Kelly, Michael G.; Janagani, Satyanarayana; Wu, Guoxian; Kincaid, John; Lonergan, David; Fang, Yunfeng; Wei, Zhi-Liang published a patent.Related Products of 39919-70-5 The title of the patent was Preparation of bicycloheteroarylamines like 2,6-naphthyridinamines and pyrido[3,4-d]pyrimidinamine as ion channel ligands and uses thereof. And the patent contained the following:

Amine compounds (shown as I; or a pharmaceutically acceptable salt, solvate or prodrug thereof; and stereoisomers and tautomers thereof; variables defined below; e.g. 7-(3-chloropyridin-2-yl)-N-[4-(trifluoromethyl)phenyl]-5,6,7,8-tetrahydropyrido[3,4-d]pyrimidin-4-amine (shown as II)) that are VR1 (VR = vanilloid receptor) antagonists are disclosed. The compounds may be prepared as pharmaceutical compositions, and may be used for the prevention and treatment of a variety of conditions in mammals including humans, including by way of nonlimiting example, pain, inflammation, traumatic injury, and others. Compounds I are considered to be particularly beneficial as VR1 antagonists as certain compounds exhibit improved aqueous solubility and metabolic stability. For I: A and B = CH2, CR2’R2′, CO, CS and NR2′; Y = CH2, CR2’R2′ and NR2′; W and Z = CR4 and N, provided that W and Z both can not be N; R1 = (un)substituted aliphatic, alkyl, heteroalkyl, acyl, aryl, heteroaryl, aralkyl, heteroalkyl; each of R2 and R2′ = H, or (un)substituted C1-C6 alkyl, C1-C6 cycloalkyl, aryl and aralkyl; R3 = (un)substituted C1-C6 alkyl, aryl, heteroaryl, heteroalkyl, cycloalkyl, cycloheteroalkyl, cycloalkenyl, cycloheteroalkenyl, bicycloalkyl, bicycloheteroalkyl, bicycloalkenyl, bicycloheteroalkenyl, bicycloaryl, and bicycloheteroaryl ring. R4 = H, or (un)substituted alkyl, (un)substituted acyl, (un)substituted acylamino, (un)substituted alkylamino, (un)substituted alkylthio, (un)substituted alkoxy, (un)substituted alkoxycarbonyl, (un)substituted alkylarylamino, (un)substituted arylalkyloxy, amino, (un)substituted aryl, arylalkyl, (un)substituted sulfoxide, (un)substituted sulfone, (un)substituted mercapto, (un)substituted aminosulfonyl, (un)substituted arylsulfonyl, sulfuric acid, sulfuric acid ester, (un)substituted dihydroxyphosphoryl, (un)substituted aminodihydroxyphosphoryl, azido, carboxy, (un)substituted carbamoyl, carboxy, cyano, (un)substituted cycloalkyl, (un)substituted cycloheteroalkyl, (un)substituted dialkylamino, halo, heteroaryloxy, (un)substituted heteroaryl, (un)substituted heteroalkyl, hydroxy, nitro, and thio. Although the methods of preparation are not claimed, 62 example preparations are included. For example, II was prepared in 5 steps (90, 38, 91, 87, 26 % yields) starting from 1-benzyl-3-(ethoxycarbonyl)-4-piperidone hydrochloride, formamidine acetate and NaOMe/MeOH and involving intermediates 7-benzyl-5,6,7,8-tetrahydropyrido[3,4-d]pyrimidin-4(3H)-one, 7-benzyl-4-chloro-5,6,7,8-tetrahydropyrido[3,4-d]pyrimidine, 7-benzyl-N-[4-(trifluoromethyl)phenyl]-5,6,7,8-tetrahydropyrido[3,4-d]pyrimidin-4-amine, and N-[4-(trifluoromethyl)phenyl]-5,6,7,8-tetrahydropyrido[3,4-d]pyrimidin-4-amine. VR1 antagonist activity for 62 examples of I, capsaicin-induced VR1 current inhibition activity for 16 examples of I, reversal of thermal hyperalgesia in rats by II, pharmacokinetic profiles for 5 examples of I and plasma protein binding ability by II are reported. The experimental process involved the reaction of 6-(tert-Butyl)pyridin-3-amine(cas: 39919-70-5).Related Products of 39919-70-5

The Article related to naphthyridinamine pyridopyrimidinamine preparation vanilloid receptor antagonist, ion channel ligand naphthyridinamine pyridopyrimidinamine preparation, pain inflammation traumatic injury drug naphthyridinamine pyridopyrimidinamine preparation and other aspects.Related Products of 39919-70-5

Referemce:
Pyridine – Wikipedia,
Pyridine | C5H5N – PubChem