Category: pyridine-derivatives

On October 15, 2007, Wang, Jian; Djukic, Brandon; Cao, Jingyi; Alberola, Antonio; Razavi, Fereidoon S.; Pilkington, Melanie published an article.HPLC of Formula: 75449-26-2 The title of the article was A novel bis tridentate bipyridine carboxamide ligand and its complexation to copper(II): synthesis, structure, and magnetism. And the article contained the following:

A new bis tridentate ligand 2,2′-bipyridine-3,3′-[2-pyridinecarboxamide] H2L1 which can bind transition metal ions was synthesized via the condensation of 3,3′-diamino-2,2′-bipyridine together with 2-pyridine carbonyl chloride. Two Cu(II) coordination compounds were prepared and characterized: [Cu2(L1)(hfac)2].3MeCN.H2O (1) and [Cu2(L1)Cl2].MeCN (2). The single-crystal x-ray structures reveal that complex 1 crystallizes in the triclinic space group P1̅, with a 12.7185(6), b 17.3792(9), c 19.4696(8) Å, α 110.827(2), β 99.890(3), γ 97.966(3)°, Z = 4, R = 0.0321 and Rw = 0.0826. Complex 2 crystallizes in the monoclinic space group P21/n with a 12.8622(12), b 9.6100(10), c 19.897(2) Å, β 102.027(3)°, Z = 4, R = 0.0409 and Rw = 0.1005. In both complexes the ligand is in the dianionic form and coordinates the divalent CuII ions via one amido and two pyridine N donor atoms. In 1, the coordination geometry around both CuII ions is best described as distorted trigonal bipyramidal where the remaining two coordination sites are satisfied by hexafluoroacetylacetonate counterions. In 2 both CuII ions adopt a (4 + 1) distorted square pyramidal geometry. One Cu forms a longer apical bond to an adjacent carbonyl O atom, whereas the second Cu is chelated to a neighboring Cu-Cl chloride ion to afford a μ-Cl-bridged dimerized [Cu2(L1)Cl2]2 complex. The magnetic susceptibility data for 1 (2 -270 K), reveal the occurrence of weak antiferromagnetic interactions between the CuII ions. In contrast, variable-temperature magnetic susceptibility measurements for 2 reveal more complex magnetic properties, with the presence of a weak antiferromagnetic exchange (J = -10.1 K) between the Cu ions in each dinuclear Cu complex and a stronger ferromagnetic exchange interaction (J = 32.9 K) between the CuII ions of the Cu(μ-Cl)2Cu dimeric bridging units. The experimental process involved the reaction of [2,2′-Bipyridine]-3,3′-diamine(cas: 75449-26-2).HPLC of Formula: 75449-26-2

The Article related to copper bipyridinepyridinecarboxamide preparation structure magnetic exchange, crystal structure copper bipyridinepyridinecarboxamide fluoroacac chloro dinuclear, exchange ferromagnetic antiferromagnetic copper bipyridinepyridinecarboxamide and other aspects.HPLC of Formula: 75449-26-2

Referemce:
Pyridine – Wikipedia,
Pyridine | C5H5N – PubChem

On August 18, 2014, Hurley, Nicholas J.; Hayward, John J.; Rawson, Jeremy M.; Murrie, Mark; Pilkington, Melanie published an article.SDS of cas: 75449-26-2 The title of the article was Exploring the Coordination Chemistry of 3,3′-Di(picolinamoyl)-2,2′-bipyridine: One Ligand, Multiple Nuclearities. And the article contained the following:

The syntheses, structures, and magnetic properties of three new coordination complexes, tetranuclear [Zn2L3(OAc)(OMe)]2·3MeOH·H2O (3), trinuclear [Ni3(L3)3]·6H2O (4), and a 1-dimensional chain {[Cu2L3(OAc)2]2·H2O}n (6), of a polydentate, doubly deprotonated, disubstituted bipyridine ligand, 3,3′-bis(picolinamido)-2,2′-bipyridine, [L3]2-, are reported. The x-ray crystal structures demonstrate that the ditopic ligand provides a flexible N3 donor set for transition metal ions where each binding pocket shifts from fac to intermediate fac/mer to the mer isomer affording a Ni3 triangle, a Zn4 tetramer, and a 1-dimensional Cu(II) polymer, resp. This variation in coordination preference is rationalized with the aim of designing future ligands with controlled coordination modes. Magnetic susceptibility studies on 4 reveal it belongs to the rare family of ferromagnetically coupled [Ni3] clusters. In contrast, magnetic studies of the 1-dimensional chain 6 reveal weak antiferromagnetic interactions due to the poor orbital overlap of the singly occupied Cu(II) dx2-y2 orbitals with the 1-atom bridge that connects them along the Jahn-Teller distortion axis. The experimental process involved the reaction of [2,2′-Bipyridine]-3,3′-diamine(cas: 75449-26-2).SDS of cas: 75449-26-2

The Article related to transition metal bispicolinamidobipyridine multinuclear complex coordination polymer preparation, crystal structure transition metal bispicolinamidobipyridine multinuclear complex coordination polymer, magnetic property transition metal bispicolinamidobipyridine multinuclear complex coordination polymer and other aspects.SDS of cas: 75449-26-2

Referemce:
Pyridine – Wikipedia,
Pyridine | C5H5N – PubChem

On July 1, 2010, Aydemir, Murat; Durap, Feyyaz; Baysal, Akin; Meric, Nermin; Buldag, Ayseguel; Guemguem, Bahattin; Oezkar, Saim; Yildirim, Leyla Tatar published an article.COA of Formula: C10H10N4 The title of the article was Novel neutral phosphinite bridged dinuclear ruthenium(II) arene complexes and their catalytic use in transfer hydrogenation of aromatic ketones: X-ray structure of a new Schiff base, N3,N3′-di-2-hydroxybenzylidene-[2,2′]bipyridinyl-3,3′-diamine. And the article contained the following:

A novel Schiff base N3,N3′-di-2-hydroxybenzylidene-[2,2′]bipyridinyl-3,3′-diamine (1) was synthesized from condensation of salicylaldehyde with 3,3′-diamino-2,2′-bipyridine. Reaction of 1 with two equivalent of PPh2Cl in the presence of Et3N proceeds in toluene to give N3,N3′-di-2-(diphenylphosphino)benzylidene-[2,2′]bipyridinyl-3,3′-diamine (2) in quant. yield. Ruthenium(II) dimers [Ru(η6-arene)(μ-Cl)Cl]2 readily react with phosphinite ligand [(Ph2PO)2-C24H16N4], 2 in toluene at room temperature, to afford the neutral derivatives [C24H16N4{OPPh2-Ru(η6-arene)Cl2}2] {arene = benzene 3; p-cymene, 4}. All the complexes were fully characterized by anal. and spectroscopic methods. 31P-{1H} NMR, 1H-13C HETCOR or 1H-1H COSY correlation experiments were used to confirm the spectral assignments. Mol. structure of the Schiff base, 1 was also determined by x-ray single crystal diffraction study. The catalytic activity of complexes 3 and 4 in the transfer hydrogenation of acetophenone derivatives was tested. Stable ruthenium(II)-phosphinite complexes were found to be efficient catalysts in the transfer hydrogenation of aromatic ketones in excellent conversions up to 99% (up to 530 per h) in the presence of iso-PrOH/KOH. The experimental process involved the reaction of [2,2′-Bipyridine]-3,3′-diamine(cas: 75449-26-2).COA of Formula: C10H10N4

The Article related to crystal structure hydroxybenzylidene bipyridinyldiamine schiff base preparation, mol structure hydroxybenzylidene bipyridinyldiamine schiff base, ruthenium schiff base phosphinite bridged dinuclear complex preparation, ketone transfer hydrogenation catalyst ruthenium schiff base phosphinite complex and other aspects.COA of Formula: C10H10N4

Referemce:
Pyridine – Wikipedia,
Pyridine | C5H5N – PubChem

Thongpaen, Jompol; Schmid, Thibault E.; Toupet, Loic; Dorcet, Vincent; Mauduit, Marc; Basle, Olivier published an article in 2018, the title of the article was Directed ortho C-H borylation catalyzed using Cp*Rh(III)-NHC complexes.Computed Properties of 1349171-28-3 And the article contains the following content:

Cp*Rh(NHC) complexes I(R = iBu, iPr, Me), derived from L-amino acids, with bulky chiral bidentate NHC-carboxylate ligands were efficiently synthesized and fully characterized including solid-state structures. These unprecedented rhodium(III) complexes demonstrated high selectivity in pyridine-directed ortho-C-H borylation of arenes under mild conditions. The experimental process involved the reaction of 2-(2-(4,4,5,5-Tetramethyl-1,3,2-dioxaborolan-2-yl)phenyl)pyridine(cas: 1349171-28-3).Computed Properties of 1349171-28-3

The Article related to directed borylation arylpyridine rhodium chiral nhc catalyst preparation phenol, phenol preparation pyridyl directed borylation oxidation rhodium nhc catalyst, crystal structure rhodium chiral nhc carboxylate half sandwich complex, mol structure rhodium chiral nhc carboxylate half sandwich complex and other aspects.Computed Properties of 1349171-28-3

Referemce:
Pyridine – Wikipedia,
Pyridine | C5H5N – PubChem

On October 31, 1994, Inaba, Minoru; Ogumi, Zempachi; Takehara, Zen-ichiro published an article.Synthetic Route of 52243-87-5 The title of the article was Application of the solid polymer electrolyte method to organic electrochemistry XVII. Indirect electrochemical debromination using viologens as microscopic phase-transfer mediators. And the article contained the following:

Solid polymer electrolyte (SPE) composite electrodes using a perfluorinated ion-exchange membrane (Nafion), which is known to be microscopically separated into hydrophilic and hydrophobic domains, were prepared Various N,N’-dialkyl-4-4′-bipyridinium salts (viologens) were incorporated in the SPE composite electrodes as phase transfer mediators. Electrochem. debromination of meso-1,2-dibromo-1,2-diphenylethane was carried out on the SPE composite electrodes. The results were compared with those obtained in an emulsion system consisting of water and dichloromethane. Of the viologen compounds tested, Pr viologen was the most effective mediator for the SPE composite electrode, while octyl viologen dibromide was the most effective mediator in the emulsion system. The active species for the debromination in the emulsion system is a doubly reduced neutral form of viologen that was generated by the disproportionation of cation radicals. The disproportionation constant, Kd, of octyl viologen cation radical in a two-phase system consisting of water and dichloromethane is 809. The reaction mechanism on the SPE composite electrode was discussed, and probably the active species was generated by disproportionation at the microscopically heterogeneous interface between the hydrophilic and hydrophobic domains of the Nafion. The experimental process involved the reaction of 1,1′-Dipropyl-[4,4′-bipyridine]-1,1′-diium bromide(cas: 52243-87-5).Synthetic Route of 52243-87-5

The Article related to indirect electrochem debromination phase transfer mediator, dibromodiphenylethane electrochem debromination composite electrode, viologen dibromodiphenylethane electrodebromination, catalyst viologen dibromodiphenylethane electrodebromination, disproportionation octylviologen radical cation and other aspects.Synthetic Route of 52243-87-5

Referemce:
Pyridine – Wikipedia,
Pyridine | C5H5N – PubChem

Rieder, Samuel; Melendez, Camilo; Denes, Fabrice; Jangra, Harish; Mulliri, Kleni; Zipse, Hendrik; Renaud, Philippe published an article in 2021, the title of the article was Radical chain monoalkylation of pyridines.SDS of cas: 908267-63-0 And the article contains the following content:

The monoalkylation of N-methoxypyridinium salts with alkyl radicals generated from alkenes (via hydroboration with catecholborane), alkyl iodides (via iodine atom transfer) and xanthates to afford alkylated quinoline derivatives R-R1 [R = 4-methylquinolinyl, 4-Cl-quinolinyl, 3-Br-quinolinyl, etc.; R1 = Et, iPr, cyclohexyl, etc.] and pyridine derivatives R2-R3 [R2 = 4-phenylpyridinyl, 4-tBu-pyridinyl, 4-Br-pyridinyl, etc.; R3 = iPr, 1-adamantyl, cyclohexyl, etc.] was reported. The reaction proceeded under neutral conditions since no acid was needed to activate the heterocycle and no external oxidant was required. A rate constant for the addition of a primary radical to N-methoxylepidinium >107 M-1 s-1 was exptl. determined This rate constant was more than one order of magnitude larger than the one measured for the addition of primary alkyl radicals to protonated lepidine demonstrating the remarkable reactivity of methoxypyridinium salts toward radicals. The reaction was used for the preparation of unique pyridinylated terpenoids and was extended to a three-component carbopyridinylation of electron-rich alkenes including enol esters, enol ethers and enamides. The experimental process involved the reaction of 4-Bromo-2-isopropylpyridine(cas: 908267-63-0).SDS of cas: 908267-63-0

The Article related to alkylated pyridine derivative preparation, pyridine derivative alkene monoalkylation, alkyl iodide pyridine derivative monoalkylation, xanthate pyridine derivative monoalkylation, derivative pyridine alkylated preparation, ester alkene pyridine derivative three component carbopyridinylation and other aspects.SDS of cas: 908267-63-0

Referemce:
Pyridine – Wikipedia,
Pyridine | C5H5N – PubChem

On March 2, 2022, Cai, Bicheng; Gong, Liang; Zhu, Yiying; Kong, Lingmei; Ju, Xiaoman; Li, Xue; Yang, Xiaodong; Zhou, Hongyu; Li, Yan published an article.Recommanded Product: N,N-Dimethyl-3-phenyl-3-(pyridin-2-yl)propan-1-amine maleate The title of the article was Identification of Gossypol Acetate as an Autophagy Modulator with Potent Anti-tumor Effect against Cancer Cells. And the article contained the following:

Autophagy, an evolutionarily conserved process, is intricately involved in many aspects of human health and a variety of human diseases, including cancer. Discovery of small-mol. autophagy modulators with potent anticancer effect would be of great significance. To this end, a natural product library consisting of 170 natural compounds were screened as autophagy modulators with potent cytotoxicity in our present study. Among these compounds, gossypol acetate (GAA), the mostly used medicinal form of gossypol, was identified. GAA effectively increased the number of autophagic puncta in GFP-LC3B-labeled 293T cells and significantly decreased cell viability in different cancer cells. In A549 cells, GAA at concentrations below 10 μM triggered caspase-independent cell death via targeting autophagy, as evidenced by elevated LC3 conversion and decreased p62/SQSTM1 levels. Knocking down of LC3 significantly attenuated GAA-induced cell death. Mechanistically, GAA at low concentrations induced autophagy through targeting AMPK-mTORC1-ULK1 signaling. Interestingly, high concentrations of GAA induced LC3 conversion, p62 accumulation, and yellow autophagosome formation, indicating that GAA at high concentrations blocked autophagic flux. Mechanistically, GAA decreased intracellular ATP level and suppressed lysosome activity. Exogenous ATP partially reversed the inhibitory effect of GAA on autophagy, suggesting that decreased ATP level and lysosome activity might be involved in the blocking of autophagy flux by GAA. Collectively, our present study reveals the mechanisms by which GAA modulates autophagy and illustrates whether autophagy regulation by GAA is functionally involved in GAA-induced cancer cell death. The experimental process involved the reaction of N,N-Dimethyl-3-phenyl-3-(pyridin-2-yl)propan-1-amine maleate(cas: 132-20-7).Recommanded Product: N,N-Dimethyl-3-phenyl-3-(pyridin-2-yl)propan-1-amine maleate

The Article related to drug screening gossypol acetate autophagy cancer, atp, adenosine 5′-monophosphate (amp)-activated protein kinase (ampk), apoptosis, autophagy, cancer cell death, gossypol acetate, lysosome, mammalian target of rapamycin complex-1 (mtorc1), unc-51-like autophagy-activating kinase 1 (ulk1) and other aspects.Recommanded Product: N,N-Dimethyl-3-phenyl-3-(pyridin-2-yl)propan-1-amine maleate

Referemce:
Pyridine – Wikipedia,
Pyridine | C5H5N – PubChem

Wang, Jian; Hayward, John J.; Gumbau-Brisa, Roger; Wallis, John D.; Stoeckli-Evans, Helen; Pilkington, Melanie published an article in 2015, the title of the article was Probing the reactivity of a 2,2′-bipyridyl-3,3′-bis-imine ligand by X-ray crystallography.Synthetic Route of 75449-26-2 And the article contains the following content:

The reactivity of a Schiff-base bis-imine ligand 3 (N3,N3-bis(2-pyridinylmethylene)[2,2′-bipyridine]3,3′-diamine) is probed by x-ray diffraction studies. Its susceptibility to hydrolysis, oxidation and nucleophilic addition reactions of 3 is demonstrated by the isolation of the methanol adduct 4 and two diazepine heterocycles 5 and 6. This reactivity is also reflected in the mol. structures of two coordination complexes isolated by the reaction of 3 with M(hfac)2 salts, to afford [Cu(5)(hfac)(tfa)] (8) and [Zn(6)(hfac)2] (9), where Hhfac = hexafluoroacetylacetone and tfa = trifluoroacetic acid. The experimental process involved the reaction of [2,2′-Bipyridine]-3,3′-diamine(cas: 75449-26-2).Synthetic Route of 75449-26-2

The Article related to crystal structure bipyridylbisimine schiff base preparation, bipyridylbisimine schiff base hydrolysis oxidation nucleophilic addition reaction product, zinc copper bipyridylbisimine schiff base complex crystal structure preparation, copper bipyridylbisimine schiff base magnetic property and other aspects.Synthetic Route of 75449-26-2

Referemce:
Pyridine – Wikipedia,
Pyridine | C5H5N – PubChem

On October 29, 2015, Basinger, Jillian; Bookser, Brett; Chen, Mi; Chung, Demichael; Gupta, Varsha; Hudson, Andrew; Kaplan, Alan; Na, James; Renick, Joel; Santora, Vincent published a patent.Related Products of 908267-63-0 The title of the patent was Preparation of substituted 2,4,5,6-tetrahydropyrrolo[3,4-c]pyrazole and 4,5,6,7-tetrahydro-2H-pyrazolo[4,3-c]pyridine compounds as GlyT1 inhibitors. And the patent contained the following:

The title compounds I [R1 = CO2H, C(O)NH2, SO2(alkyl), etc.; R2 = H, halo, alkyl, etc.; R3 = H, alkyl, haloalkyl, etc.; R4 = H, F, alkyl, etc.; R5 = alkyl, haloalkyl, alkoxy, etc.; X = (CR)1-2; R = H, alkyl], useful in a wide range of methods, including metabolic and reaction kinetic studies; detection and imaging techniques; radioactive treatments; modulating and treating disorders mediated by GlyT1 activity; treating neurol. disorders, CNS disorders, dementia, neurodegenerative diseases, and trauma-dependent losses of function; treating stroke, including cognitive and motor deficits during stroke rehabilitation; facilitating neuroprotection and neurorecovery; enhancing the efficiency of cognitive and motor training, including animal skill training; and treating other disorders, including pain and alc.-dependence, were prepared E.g., a multi-step synthesis of II, starting from tert-Bu 4,6-dihydropyrrolo[3,4-c]pyrazole-5(2H)-carboxylate and 1-fluoro-4-iodobenzene, was described. The exemplified compounds I were their GlyT1 inhibitory activity (data given). Pharmaceutical composition comprising I is disclosed. The experimental process involved the reaction of 4-Bromo-2-isopropylpyridine(cas: 908267-63-0).Related Products of 908267-63-0

The Article related to pyrrolopyrazole pyrazolopyridine preparation glyt1 inhibitor neurol disorder treatment, cns agent cognition enhancer neuroprotection pyrrolopyrazole pyrazolopyridine preparation glyt1, dementia neurodegenerative disease stroke motor deficit pyrrolopyrazole pyrazolopyridine preparation and other aspects.Related Products of 908267-63-0

Referemce:
Pyridine – Wikipedia,
Pyridine | C5H5N – PubChem

On May 7, 1998, Ankersen, Michael; Dorwald, Florenzio Zaragoza; Stidsen, Carsten Enggaard; Crider, Albert Michael published a patent.Product Details of 199522-66-2 The title of the patent was Preparation of thiourea derivatives and related compounds as constrained somatostatin agonists and antagonists. And the patent contained the following:

The title compounds B(CH2)nNA(CH2)mYNR1C(:X)E [I; A = (un)substituted aryl; B = (un)substituted aryl; E = heterocyclyl, amino; R1 = H, (un)substituted C1-6 alkyl; X = S, O, NR3; R3 = H, COPh, cyano; Y = bond, etc.; m = 0-6; n = 0-3], somatostatin agonists and antagonists (no data) useful for treating medical disorders related to binding to human somatostatin receptor subtypes, and their pharmaceutically acceptable salts were prepared and claimed. For example, amination of 2,5-dibromopyridine with H2NCH2CH2NH2 in pyridine gave N-1-(5-bromopyrid-2-yl)ethane-1,2-diamine which was benzylated with 3,4-dichlorobenzyl chloride in DMSO in the presence of NaH and the product condensed with CS2 in the presence of dicyclohexylcarbodiimide in THF to give 2-[N-(5-bromopyrid-2-yl)-N-(3,4-dichlorobenzyl)]aminoethyl isothiocyanate. Addition of the latter with 4-[4(5)-imidazolyl]piperidine-2HCl in THF in the presence of Et3N gave a title compound I. The experimental process involved the reaction of N1-(5-Bromopyrid-2-yl)ethane-1,2-diamine(cas: 199522-66-2).Product Details of 199522-66-2

The Article related to thiourea derivative preparation somatostatin agonist, imidazolylpiperidinecarbothioic acid bromopyridinyldichlorobenzylaminoethylamide, ethanediamine amination dibromopyridine somatostatin agonist preparation, bromopyridylethanediamine preparation benzylation dichlorobenzyl chloride and other aspects.Product Details of 199522-66-2

Referemce:
Pyridine – Wikipedia,
Pyridine | C5H5N – PubChem