Category: pyridine-derivatives

Murugesan, Kathiravan; Beller, Matthias; Jagadeesh, Rajenahally V. published the artcile< Reusable Nickel Nanoparticles-Catalyzed Reductive Amination for Selective Synthesis of Primary Amines>, Synthetic Route of 350-03-8, the main research area is primary amine preparation nickel nanoparticle catalyst; carbonyl compound ammonia mol hydrogen reductive amination; ammonia; carbonyl compounds; nickel nanoparticles; primary amines; reductive amination.

The preparation of nickel nanoparticles as efficient reductive amination catalysts by pyrolysis of in situ generated Ni-tartaric acid complex on silica is presented. The resulting stable and reusable Ni-nanocatalyst enables the synthesis of functionalized and structurally diverse primary benzylic, heterocyclic and aliphatic amines starting from inexpensive and readily available carbonyl compounds and ammonia in presence of mol. hydrogen. Applying this Ni-based amination protocol, -NH2 moiety can be introduced in structurally complex compounds, for example, steroid derivatives and pharmaceuticals.

Angewandte Chemie, International Edition published new progress about Carbonyl compounds (organic) Role: RCT (Reactant), RACT (Reactant or Reagent). 350-03-8 belongs to class pyridine-derivatives, and the molecular formula is C7H7NO, Synthetic Route of 350-03-8.

Referemce:
Pyridine – Wikipedia,
Pyridine | C5H5N – PubChem

Liu, Jianbo; Yuan, Qianjia; Toste, F. Dean; Sigman, Matthew S. published the artcile< Enantioselective construction of remote tertiary carbon-fluorine bonds>, Formula: C13H15F3N2O, the main research area is tertiary benzylic fluoroalkane enantioselective synthesis; enantioselective Heck coupling acyclic alkenyl fluoride arylboronic acid.

The carbon-fluorine bond engenders distinctive physicochem. properties and significant changes to general reactivity. The development of catalytic, enantioselective methods to set stereocenters that contain a benzylic C-F bond is a rapidly evolving goal in synthetic chem. Although there have been notable advances that enable the construction of secondary stereocenters that contain both a C-F and a C-H bond on the same carbon, significantly fewer strategies are defined to access stereocenters that incorporate a tertiary C-F bond, especially those remote from pre-existing activating groups. Here we report a general method that establishes C-F tertiary benzylic stereocenters by forging a C-C bond via a Pd-catalyzed enantioselective Heck reaction of acyclic alkenyl fluorides with arylboronic acids. This method provides a platform to rapidly incorporate significant functionality about the benzylic tertiary fluoride by virtue of the diversity of both reaction partners, as well as the ability to install the stereocenters remotely from pre-existing functional groups.

Nature Chemistry published new progress about Allylic alcohols Role: RCT (Reactant), SPN (Synthetic Preparation), RACT (Reactant or Reagent), PREP (Preparation). 1416819-91-4 belongs to class pyridine-derivatives, and the molecular formula is C13H15F3N2O, Formula: C13H15F3N2O.

Referemce:
Pyridine – Wikipedia,
Pyridine | C5H5N – PubChem

Anderson, Enyia R.; Patterson, Edward I.; Richards, Siobhan; Pitol, Ana K.; Edwards, Thomas; Wooding, Dominic; Buist, Kate; Green, Alison; Mukherjee, Sayandip; Hoptroff, Michael; Hughes, Grant L. published the artcile< CPC-containing oral rinses inactivate SARS-CoV-2 variants and are active in the presence of human saliva>, Reference of 123-03-5, the main research area is SARS CoV2 cetylpyridinium chloride chlorhexidine digluconate saliva aerosol mouthwash; COVID-19; SARS-CoV-2; mouthwash; oral hygiene; saliva.

The importance of human saliva in aerosol-based transmission of SARS-CoV-2 is now widely recognized. However, little is known about the efficacy of virucidal mouthwash formulations against emergent SARS-CoV-2 variants of concern and in the presence of saliva. Hypothesis. Mouthwashes containing virucidal actives will have similar inactivation effects against multiple SARS-CoV-2 variants of concern and will retain efficacy in the presence of human saliva. To examine in vitro efficacy of mouthwash formulations to inactivate SARS-CoV-2 variants. Methodol. Inactivation of SARS-CoV-2 variants by mouthwash formulations in the presence or absence of human saliva was assayed using ASTM International Standard E1052-20 methodol. Appropriately formulated mouthwashes containing 0.07% cetylpyridinium chloride but not 0.2% chlorhexidine completely inactivated SARS-CoV-2 (USA-WA1/2020, Alpha, Beta, Gamma, Delta) up to the limit of detection in suspension assays. Tests using USA-WA1/2020 indicates that efficacy is maintained in the presence of human saliva. Together these data suggest cetylpyridinium chloride-based mouthwashes are effective at inactivating SARS-CoV-2 variants. This indicates potential to reduce viral load in the oral cavity and mitigate transmission via salivary aerosols.

Journal of Medical Microbiology published new progress about Antiviral agents. 123-03-5 belongs to class pyridine-derivatives, and the molecular formula is C21H38ClN, Reference of 123-03-5.

Referemce:
Pyridine – Wikipedia,
Pyridine | C5H5N – PubChem

Kim, Yung-Yoon; Uezu, Kazuya published the artcile< Functional Microfiber Nonwoven Fabric with Copper Ion-Immobilized Polymer Brush for Detection and Adsorption of Acetone Gas>, Quality Control of 3731-53-1, the main research area is copper ion immobilization polymer brush MNWF acetone gas adsorption; 4-picolylamine; VOCs; acetone; coordination bonding; copper ions; microfiber nonwoven fabric; radiation-induced graft polymerization.

The detection and removal of volatile organic compounds (VOCs) are emerging as an important problem in modern society. In this study, we attempted to develop a new material capable of detecting or adsorbing VOCs by introducing a new functional group and immobilizing metal ions into a microfiber nonwoven fabric (MNWF) made through radiation-induced graft polymerization The suitable metal complex was selected according to the data in “”Cambridge Crystallog. Data Center (CCDC)””. The 4-picolylamine (4-AMP), designated as a ligand through the metal complex data of CCDC, was introduced at an average mole conversion rate of 63%, and copper ions were immobilized at 0.51 mmol/g to the maximum It was confirmed that degree of grafting (dg) 170% 4-AMP-Cu MNWF, where copper ions are immobilized, can adsorb up to 50% of acetone gas at about 50 ppm, 0.04 mmol/g- 4-AMP-Cu-MNWF, at room temperature and at a ratio of copper ion to adsorbed acetone of 1:10.

Sensors published new progress about Adsorption. 3731-53-1 belongs to class pyridine-derivatives, and the molecular formula is C6H8N2, Quality Control of 3731-53-1.

Referemce:
Pyridine – Wikipedia,
Pyridine | C5H5N – PubChem

Blumbergs, Peter; Ash, Arthur B.; Daniher, F. A.; Stevens, Calvin Lee; Michel, H. O.; Hackley, B. E. Jr.; Epstein, J. published the artcile< Alkylating agents containing a quaternary nitrogen group>, Category: pyridine-derivatives, the main research area is alkylating sulfonates; sulfonates alkylating; pyridinium sulfonates.

A series of 18 new, water-soluble alkylating agents was synthesized. The structures contain an alkylsulfonate group as the alkylating function and a quaternary ammonium salt group attached to a hydrocarbon backbone. Some pyridinium sulfonates perchlorates were also prepared

Journal of Organic Chemistry published new progress about 21876-43-7. 21876-43-7 belongs to class pyridine-derivatives, and the molecular formula is C9H13NO3S, Category: pyridine-derivatives.

Referemce:
Pyridine – Wikipedia,
Pyridine | C5H5N – PubChem

Alhatem, Aamer A. published the artcile< Tautomeric equilibria of substituted 2-pyridone/2-hydroxypyridine in the gas and aqueous phases>, Safety of 6-Chloropyridin-2-ol, the main research area is pyridone hydroxypyridine tautomer substituent effects formation enthalpy free energy.

Heats of formation, entropies and Gibbs free energies for the twenty structures of substituted 2-pyridone and 2-hydroxypyridine were studied using semiempirical Austin Model (AM1) and Parametric Method 3 (PM3) calculations at the SCF level, both in the gas and liquid phases, with full geometry optimization. It was revealed from the study that 2-hydroxypyridine is predominant in gas phase, while 2-pyridone in the liquid phase which agrees with the exptl. and theor. predictions. All substituents such as F, Cl, OH, CH3, NH2, NO2, CHO, CN, CF3 stabilize the 2-pyridone in the gas and liquid phases except F, Cl and NH2 in PM3 calculations in the gas phase. The substituents stabilization is more effective in liquid phase. This was also confirmed by thermodn. calculations and isodesmic reactions.

Chemical Science International Journal published new progress about Entropy. 73018-09-4 belongs to class pyridine-derivatives, and the molecular formula is C5H4ClNO, Safety of 6-Chloropyridin-2-ol.

Referemce:
Pyridine – Wikipedia,
Pyridine | C5H5N – PubChem

Bellini, Michela; Riva, Benedetta; Tinelli, Veronica; Rizzuto, Maria Antonietta; Salvioni, Lucia; Colombo, Miriam; Mingozzi, Francesca; Visioli, Alberto; Marongiu, Laura; Frascotti, Gianni; Christodoulou, Michael S.; Passarella, Daniele; Prosperi, Davide; Fiandra, Luisa published the artcile< Engineered Ferritin Nanoparticles for the Bioluminescence Tracking of Nanodrug Delivery in Cancer>, Synthetic Route of 2127-03-9, the main research area is ferritin nanoparticle bioluminescence imaging cancer; apoferritin nanoparticles; luciferase/luciferin; nanomedicine; self-immolative linkers; tumor targeting.

The identification of a highly sensitive method to check the delivery of administered nanodrugs into the tumor cells is a crucial step of preclin. studies aimed to develop new nanoformulated cures, since it allows the real therapeutic potential of these devices to be forecast. In the present work, the ability of an H-ferritin (HFn) nanocage, already investigated as a powerful tool for cancer therapy thanks to its ability to actively interact with the transferrin receptor 1, to act as an efficient probe for the monitoring of nanodrug delivery to tumors is demonstrated. The final formulation is a bioluminescent nanoparticle, where the luciferin probe is conjugated on nanoparticle surface by means of a disulfide containing linker (Luc-linker@HFn) which is subjected to glutathione-induced cyclization in tumor cell cytoplasm. The prolonged imaging of luciferase+ tumor models, demonstrated by an in vitro and an in vivo approach, associated with the prolonged release of luciferin into cancer cells by disulfide bridge reduction, clearly indicates the high efficiency of Luc-linker@HFn for drug delivery to the tumor tissues.

Small published new progress about Apoferritins Role: NAN (Nanomaterial), THU (Therapeutic Use), BIOL (Biological Study), USES (Uses). 2127-03-9 belongs to class pyridine-derivatives, and the molecular formula is C10H8N2S2, Synthetic Route of 2127-03-9.

Referemce:
Pyridine – Wikipedia,
Pyridine | C5H5N – PubChem

Halevas, E.; Papadopoulos, T. A.; Swanson, C. H.; Smith, G. C.; Hatzidimitriou, A.; Katsipis, G.; Pantazaki, A.; Sanakis, I.; Mitrikas, G.; Ypsilantis, K.; Litsardakis, G.; Salifoglou, A. published the artcile< In-depth synthetic, physicochemical and in vitro biological investigation of a new ternary V(IV) antioxidant material based on curcumin>, SDS of cas: 366-18-7, the main research area is ternary vanadium curcumin bipyridine complex preparation antioxidant crystal structure; Bioreactivity profile and antioxidant agent; Cell metabolism inhibition and DNA degradation; Crystal structure and DFT calculations; Hybrid metallopharmaceutical; ROS-suppression; Vanadium-curcumin complex.

Curcumin is a natural product with a broad spectrum of beneficial properties relating to pharmaceutical applications, extending from traditional remedies to modern cosmetics. The biol. activity of such pigments, however, is limited by their solubility and bioavailability, thereby necessitating new ways of achieving optimal tissue cellular response and efficacy as drugs. Metal ion complexation provides a significant route toward improvement of curcumin stability and biol. activity, with vanadium being a representative such metal ion, amply encountered in biol. systems and exhibiting exogenous bioactivity through potential pharmaceuticals. Driven by the need to optimally increase curcumin bioavailability and bioactivity through complexation, synthetic efforts were launched to seek out stable species, ultimately leading to the synthesis and isolation of a new ternary V(IV)-curcumin-(2,2′-bipyridine) complex. Physicochem. characterization (elemental anal., FT-IR, Thermogravimetry (TGA), UV-Visible, NMR, ESI-MS, Fluorescence, X-rays) portrayed the solid-state and solution properties of the ternary complex. Pulsed-EPR spectroscopy, in frozen solutions, suggested the presence of two species, cis- and trans-conformers. D. Functional Theory (DFT) calculations revealed the salient features and energetics of the two conformers, thereby complementing EPR spectroscopy. The well-described profile of the vanadium species led to its in vitro biol. investigation involving toxicity, cell metabolism inhibition in S. cerevisiae cultures, Reactive Oxygen Species (ROS)-suppressing capacity, lipid peroxidation, and plasmid DNA degradation A multitude of bio-assays and methodologies, in comparison to free curcumin, showed that it exhibits its antioxidant potential in a concentration-dependent fashion, thereby formulating a bioreactivity profile supporting development of new efficient vanado-pharmaceuticals, targeting (extra)intra-cellular processes under (patho)physiol. conditions.

Journal of Inorganic Biochemistry published new progress about Antioxidants. 366-18-7 belongs to class pyridine-derivatives, and the molecular formula is C10H8N2, SDS of cas: 366-18-7.

Referemce:
Pyridine – Wikipedia,
Pyridine | C5H5N – PubChem

Ali, Hazim M. published the artcile< Simultaneous Determination of Methyl Nicotinate and Three Salicylic Acid Derivatives in Pain Relief Spray Using HPLC-DAD>, COA of Formula: C7H7NO2, the main research area is methyl nicotinate salicylic acid derivative pain relief spray HPLCDAD.

For the first time, the high-performance liquid chromatog.-diode array detector (HPLC-DAD) approach was operated for the simultaneous assessment of Me nicotinate (MN), Me salicylate (MS), Et salicylate (ES) and 2-hydroxyethyl salicylate (HES) in one pharmaceutical formulation. The limits of detection of MN, HES, MS and ES were found to be 0.0144, 0.0455, 0.0087 and 0.0061μg/mL. The recovery percentages and relative standard deviations ranged from 93.48 to 102.12% and 0.301 to 6.341% for all active ingredients. Accordingly, the previously described data demonstrate the sensitivity, accuracy and precision of the developed method. Therefore, the investigated approach was effectively applied for the simultaneous assessment of MN, HES, MS and ES in DEEP HEAT Spray.

Separations published new progress about Analgesics. 93-60-7 belongs to class pyridine-derivatives, and the molecular formula is C7H7NO2, COA of Formula: C7H7NO2.

Referemce:
Pyridine – Wikipedia,
Pyridine | C5H5N – PubChem

Miranda, Margarida S.; Matos, Maria Agostinha R.; Morais, Victor M. F. published the artcile< Structure and energetics correlations in some chlorohydroxypyridines>, COA of Formula: C5H4ClNO, the main research area is chlorohydroxypyridine structure energetics correlation.

We have performed a study of the structure and energetics of some chlorohydroxypyridines based on exptl. calorimetry techniques and high level ab initio computational calculations The standard (p° = 0.1 MPa) molar enthalpies of formation of 2-chloro-3-hydroxypyridine (2-Cl-3-OHPy), 2-chloro-6-hydroxypyridine (2-Cl-6-OHPy) and 3-chloro-5-hydroxypyridine (3-Cl-5-OHPy) in the crystalline phase, at T = 298.15 K, were derived from the resp. standard massic energies of combustion measured by rotating-bomb combustion calorimetry, in oxygen, at T = 298.15 K. The standard molar enthalpies of sublimation, at T = 298.15 K, were measured by Calvet microcalorimetry. From these exptl. determined enthalpic parameters we have derived the standard molar enthalpies of formation of the three compounds in the gaseous phase, at T = 298.15 K: 2-Cl-3-OHPy, -(76.8 ± 2.0) kJ · mol-1; 2-Cl-6-OHPy, -(105.0 ± 1.7) kJ · mol-1, 3-Cl-5-OHPy -(61.2 ± 2.4) kJ · mol-1. These values were compared with estimates obtained from very accurate computational calculations using the G3(MP2)//B3LYP composite method and appropriately chosen reactions. These calculations have also been extended to the remaining chlorohydroxypyridine isomers that were not studied exptl. Based on B3LYP/6-31G* optimized geometries and calculated G3(MP2)//B3LYP absolute enthalpies some structure-energy correlations were discussed.

Journal of Chemical Thermodynamics published new progress about Formation enthalpy (molar). 96630-88-5 belongs to class pyridine-derivatives, and the molecular formula is C5H4ClNO, COA of Formula: C5H4ClNO.

Referemce:
Pyridine – Wikipedia,
Pyridine | C5H5N – PubChem