Pyridine-derivatives

Related Products of 113124-09-7, The major producers of chemicals have been the Europe, Japan and China. Due to the growing call for a cleaner, greener environment, people will have to find innovative ways to maintain their relevance. Here is a compound 113124-09-7, name is 5,6-Dimethylnicotinonitrile. This compound has unique chemical properties. The synthetic route is as follows.

13,0 g of trifluoromethane sulfonic acid was added dropwise to a mixture of 0,91 g (7,0 mmol)2,3-dimethylpyridi ne-5-carbonitrile and 2,0 g (9,0 mmol) I -(2-fluorophenyl)-2-(2-pyridyl)propan-2-olin 40 ml dichloroethane at 0 – 5C. After 2 days at room temperature the reaction mixture was poured onto sodium carbonate solution, the organic layer was separated and the aqueous layer was extracted with dichloromethane. The combined organic extracts were extracted withsodium hydrogen carbonate and water, evaporated and the residue was purified via MPLC with water/acetonitrile mixtures to yield 0,11 g (4 %) of the title compound as a light yellow oil. 1H.NMR (CDCI3, 6 in ppm): 8,7 (s, 1H); 8,6 (d, 1H); 7,8 (m, 2H); 7,6 (m, 1H); 7,3-7,1 (m, 4H);3,4 (d, IH); 3,3, (d, IH); 2,6 (s, 3H); 2,4 (s, 3H); 1,6 (s, 6H).*HPLCMS: Rt = 0,743 mm; M+H = 346,1

While traditionally a conservative industry, chemical producers will need to modernize their PR strategies to stay relevant.we look forward to future research findings about 113124-09-7, 5,6-Dimethylnicotinonitrile.

Reference:
Patent; BASF SE; MUELLER, Bernd; CAMBEIS, Erica; LOHMANN, Jan Klaas; ESCRIBANO CUESTA, Ana; WOLF, Antje; FEHR, Marcus; RIEDIGER, Nadine; TERTERYAN-SEISER, Violeta; GRAMMENOS, Wassilios; WINTER, Christian; (151 pag.)WO2018/54721; (2018); A1;,
Pyridine – Wikipedia,
Pyridine | C5H5N – PubChem

Synthetic Route of 1195-59-1 , The common heterocyclic compound, 1195-59-1, name is 2,6-Pyridinedimethanol, molecular formula is C7H9NO2, its traditional synthetic route has been very mature, but the traditional synthetic route has various shortcomings, such as complicated route, low yield, poor purity, etc., below Introduce a new synthetic route.

A) Synthesis of 2,6-bis-(chloromethyl)pyridine To thionyl chloride (11.6 ml, 158 mmoles), cooled at 0 C., 2,6-bis-(hydroxymethyl)pyridine (4 g, 28 mmoles) is added very slowly. The obtained solution is left under stirring for 2 hours at room temperature, then the thionyl chloride in excess is evaporated at a reduced pressure. The obtained residue is treated with chloroform and it is evaporated again at a reduced pressure to remove the thionyl chloride residues. The raw product is treated with chloroform and washed with water. The organic phase is anhydrified with sodium sulphate and dried obtaining 4.81 g of the product as white solid having melting point=76-78 C.

The synthetic route of 1195-59-1 has been constantly updated, and we look forward to future research findings.

Reference:
Patent; Del Soldato, Piero; Benedini, Francesca; Antognazza, Patrizia; US2004/23933; (2004); A1;,
Pyridine – Wikipedia,
Pyridine | C5H5N – PubChem

Related Products of 142404-69-1, Adding some certain compound to certain chemical reactions, such as: 142404-69-1, name is 2-(Chloro(4-chlorophenyl)methyl)pyridine,molecular formula is C12H9Cl2N, can increase the reaction rate and produce products with better performance than those obtained under traditional synthetic methods. Here is a downstream synthesis route of the compound 142404-69-1.

General procedure: To a stirred solution of (1-(2-phenoxyethyl)piperidin-4-yl)methanol (0.3 g, 1.27 mmol) in THF (5 mL) was added sodium hydride (0.046 g, 1.9 mmol, 1.5 equiv) and 10 minutes later, 2-(chloro(4-chlorophenyl)methyl)pyridine (0.304 g, 1.27 mmol, 1.0 equiv) at room temperature. The reaction mixture was heated at 80 C and stirred for 16 h. After completion,water was added to the reaction mixture and extracted with EtOAc. The combined organic extract was washed with brine, dried over sodium sulphate, filtered and concentrated under reduced pressure. Purification using prep HPLC purification to furnish 0.0 12 g of 2-((4- chlorophenyl)(( 1 -(2-phenoxyethyl)piperidin-4-yl)methoxy)methyl)pyridine (Yield = 2%). 1H NMR (400 MHz, CD3OD-d4): 8.45-8.43 (m, 1H), 7.86-7.82 (m, 1H), 7.62-7.60 (m, 1H),7.39-7.36 (m, 2H), 7.32-7.23 (m, 5H), 6.93-6.89 (m, 3H), 5.42 (s, 1H), 4.12 (t, 2H, J =5.6Hz), 3.36 (d, 2H, J = 6.0Hz), 3.07 (d, 2H, J = 11.6Hz), 2.82 (t, 2H, J = 5.6Hz), 2.22-2.16 (m, 2H), 1.89-1.69 (m, 3H), 1.46-1.36 (m, 2H); ESI+ MS: m/z: 437 ([M + Hj).

In the field of chemistry, the synthetic routes of compounds are constantly being developed and updated. I will also mention this compound in other articles. 142404-69-1, 2-(Chloro(4-chlorophenyl)methyl)pyridine, other downstream synthetic routes, hurry up and to see.

Reference:
Patent; THE BROAD INSTITUTE, INC.; MASSACHUSETTS INSTITUTE OF TECHNOLOGY; HOLSON, Edward; WAGNER, Florence, Fevrier; WEIWER, Michel; SCOLNICK, Edward; PALMER, Michelle; LEWIS, Michael; PAN, Jennifer, Q.; ZHANG, Yan-Ling; XU, Qihong; (323 pag.)WO2016/100823; (2016); A1;,
Pyridine – Wikipedia,
Pyridine | C5H5N – PubChem

Application of 958358-00-4 ,Some common heterocyclic compound, 958358-00-4, molecular formula is C8H7BrN2, its traditional synthetic route has been very mature, but the traditional synthetic route has various shortcomings, such as complicated route, low yield, poor purity, etc., below Introduce a new synthetic route.

Di-tert-butyl dicarbonate (2.45 g) was added in one portion to a mixture of 5-bromo- 6-methyl-lH-pyrrolo[2,3-b]pyridine (1.97g) and methylene chloride (100 ml). 4-Dimethylaminopyridine (0.011 g) was added and the reaction mixture was stirred at ambient temperature for 16 hours. The resultant mixture was evaporated and the residual oil was purified by column chromatography on silica using a 5:1 mixture of isohexane and methanol as eluent. There was thus obtained 5-bromo-l-fert-butoxycarbonyl-6-methyl- lH-rhoyrrolo[2,3-b]rhoyridine as a solid (2.34 g); 1H NMR Spectrum: (DMSOd6) 1.62 (s, 9H), 2.66 (s, 3H), 6.63 (d, IH), 7.75 (d, IH), 8.27 (s, IH); Mass Spectrum: M+H1″ 309.

These compound has a wide range of applications. It is believed that with the continuous development of the source of the synthetic route,958358-00-4, its application will become more common.

Reference:
Patent; ASTRAZENECA AB; ASTRAZENECA UK LIMITED; WO2007/135398; (2007); A1;,
Pyridine – Wikipedia,
Pyridine | C5H5N – PubChem

As we all know, there are many different methods for the synthesis of a compound, and people can choose the synthesis method that suits their own laboratory according to the actual situation. 133627-45-9, name is 2-Chloro-4-methylpyridin-3-amine, molecular formula is C6H7ClN2, The compound is widely used in many fields, so it is necessary to find a new synthetic route. The downstream synthesis method of this compound is introduced below. HPLC of Formula: C6H7ClN2

(1) Synthesis of 3-bromo-2-chloro-4-methylpyridine 3-amino-2-chloro-4-methylpyridine (2 g) was added to a mixed solvent of a 48% aqueous hydrogen bromide solution (17 mL) and water (12 mL). Sodium nitrite (2.5 g) was added to the solution at 0 C. Further, bromine (22 mL) was added. The reaction mixture was warmed to room temperature and stirred for 12 hours. The reaction mixture was partitioned by adding a 5 N aqueous sodium hydroxide solution and ethyl acetate. The organic layer was washed with brine and then dried over anhydrous magnesium sulfate. The desiccant was removed by filtration. The filtrate was concentrated under reduced pressure to give the title compound (1.7 g). 1H-NMR (400 MHz, CDCl3) delta (ppm): 2.51 (s, 3H), 7.01-7.24 (m, 1H), 8.06-8.35 (m, 1H).

With the rapid development of chemical substances, we look forward to future research findings about 133627-45-9.

Reference:
Patent; EISAI R&D MANAGEMENT CO., LTD.; Norimine, Yoshihiko; Takeda, Kunitoshi; Hagiwara, Koji; Suzuki, Yuichi; Ishihara, Yuki; Sato, Nobuaki; US2013/143907; (2013); A1;,
Pyridine – Wikipedia,
Pyridine | C5H5N – PubChem

Related Products of 186593-43-1, Adding some certain compound to certain chemical reactions, such as: 186593-43-1, name is 5-Amino-3-bromo-2-methylpyridine,molecular formula is C6H7BrN2, can increase the reaction rate and produce products with better performance than those obtained under traditional synthetic methods. Here is a downstream synthesis route of the compound 186593-43-1.

General procedure: 1.2.2.1. General method Bl To a stirred solution of Intermediate Gen-1 (1 to 1.2 eq.), and amine derivative (1 eq.) in DCM or DMF are added TBTU or HATU (1 to 1.2 eq.) followed by TEA or NMM (2 to 3 eq.) at room temperature under argon, the reaction mixture is stirred at room temperature until completion. Then the reaction is quenched with water, the layers are separated. The organic layer is dried over Na2SO i, filtered and evaporated to dryness. Alternatively, the reaction is concentrated in vacuo, the residue is partionned between EtOAc or a mixture of EtOAc/nBuOH and a saturated aqueous NH4C1 solution or water. The layers are separated, the organic layer is dried over Na2S04, filtered and evaporated to dryness. Then the residue is purified by chromatography on silica gel to afford the expected Intermediate.

According to the analysis of related databases, 186593-43-1, the application of this compound in the production field has become more and more popular.

Reference:
Patent; GALAPAGOS NV; SANIERE, Laurent Raymond Maurice; HUCK, Jacques; DYKES, Graeme James; SCHMITT, Benoit Antoine; BLANC, Javier; BUTLER, Anna Sara; BEAUMONT, Stephane Nicolas Alain; BONNATERRE, Florence Marie-Emilie; WO2015/24905; (2015); A1;,
Pyridine – Wikipedia,
Pyridine | C5H5N – PubChem

Synthetic Route of 15128-82-2 ,Some common heterocyclic compound, 15128-82-2, molecular formula is C5H4N2O3, its traditional synthetic route has been very mature, but the traditional synthetic route has various shortcomings, such as complicated route, low yield, poor purity, etc., below Introduce a new synthetic route.

(S)-1-(2,6-dichloro-3-fluorophenyl)ethanol (20.9 g, 0.10 mol) was dissolved in 200 mL anhydrous tetrahydofuran, to which 3-hydroxy-2-nitropyridine (16.0 g, 0.11 mol) and triphenylphosphine (40.0 g, 0.15 mol) were sequentially added under a nitrogen atmosphere, and the reaction solution was stirred at room temperature for 1 hour, cooled to 0 C. and diisopropyl azodicarboxylate (40 mL, 0.15 mol) was added dropwise. After the addition was complete, stirring was continued at 0 C. for 12 hours. The solvent was distilled off to obtain an oily material, which was separated by silica gel column chromatography, to give (R)-3-(1-(2,6-dichloro-3-fluorophenyl)ethoxy)-2-nitropyridine (20.2 g). Yield: 61%.

These compound has a wide range of applications. It is believed that with the continuous development of the source of the synthetic route,15128-82-2, its application will become more common.

Reference:
Patent; Chia Tai Tianqing Pharmaceutical Group Co., Ltd.; LIANYUNGANG RUNZHONG PHARMACEUTICAL CO., LTD.; CENTAURUS BIOPHARMA CO., LTD.; GONG, Feng; LI, Xinlu; ZHAO, Rui; ZHANG, Xiquan; XU, Xinhe; LIU, Xijie; XIAO, Dengming; HAN, Yongxin; (22 pag.)US2018/244649; (2018); A1;,
Pyridine – Wikipedia,
Pyridine | C5H5N – PubChem

Adding a certain compound to certain chemical reactions, such as: 626-05-1, 2,6-Dibromopyridine, can increase the reaction rate and produce products with better performance than those obtained under traditional synthetic methods. Here is a downstream synthesis route of the compound, Recommanded Product: 626-05-1, blongs to pyridine-derivatives compound. Recommanded Product: 626-05-1

n-Butyl magnesium chloride (2.0 M in THF, 2.25 ml, 45 mmol) was added to a stirred solution of w-butyl lithium (1.6 M in hexanes, 5.56 ml, 8.9 mmol) at 0C under argon. After 10 minutes at 0C the mixture was cooled to -10C. A solution of 2,6-dibromopyridine (3.0 g, 12.7 mmol) in toluene (35 ml) was added over 10 minutes and the mixture was stirred at -10 for 2 hours. After cooling to -40C, sulfur dioxide gas was bubbled into the mixture for 5 minutes and the reaction was stirred at -40C for 30 minutes. Sulfuryl chloride (1.1 ml, 13.6 mmol) was added and the mixture was allowed to warm to room temperature. The resulting mixture was added over 5 minutes to a stirred mixture of phenol (1.25 g, 13.3 mmol) and triethylamine (7.0 ml, 50.6 mmol) in acetonitrile (30 ml) at 0C. The mixture was stirred at 0C for 30 minutes and then at room temperature for 2 hours. The mixture was concentrated in vacuo and the residue partitioned between ethyl acetate and dilute sodium bicarbonate solution. The organic phase was washed with water, brine, dried over anhydrous magnesium sulfate and concentrated in vacuo to afford the title product (D7). MS(ES+) m/e 314/316 [M+H]+.

At the same time, in my other blogs, there are other synthetic methods of this type of compound,626-05-1, 2,6-Dibromopyridine, and friends who are interested can also refer to it.

Reference:
Patent; GLAXO GROUP LIMITED; WO2006/10629; (2006); A1;,
Pyridine – Wikipedia,
Pyridine | C5H5N – PubChem

Synthetic Route of 107504-08-5, Researchers who often do experiments know that organic synthesis is a process of preparing more complex target molecules from simple raw materials through one or more chemical reactions. Generally, it requires fewer steps,and cheap raw materials. 107504-08-5, name is 5-Fluoro-2-picolinic acid. A new synthetic method of this compound is introduced below.

General procedure: 5-fluoropicolinic acid (8.0 g, 56.7 mmol) was dissolved in methanol (50 mL),Dichlorosulfoxide (13.5 g, 113.4 mmol) was added, heated to 70 C. for 16 hours, and concentrated, and the residue was used directly in the next step. (8.0g, yield: 90.9%)

These compound has a wide range of applications. It is believed that with the continuous development of the source of the synthetic route,107504-08-5, its application will become more common.

Reference:
Patent; Shandong Xuanzhu Pharmaceutical Technology Co., Ltd.; Wang Tingzhong; Liu Bin; (31 pag.)CN110698471; (2020); A;,
Pyridine – Wikipedia,
Pyridine | C5H5N – PubChem

Synthetic Route of 137640-84-7, The major producers of chemicals have been the Europe, Japan and China. Due to the growing call for a cleaner, greener environment, people will have to find innovative ways to maintain their relevance. Here is a compound 137640-84-7, name is 6-(3-(Trifluoromethyl)phenoxy)picolinic acid. This compound has unique chemical properties. The synthetic route is as follows.

To a 500 mL three-necked flask was added 2-(3-trifluoromethylphenoxy)-6-pyridinecarboxylic acid 28.3 g (0.1 mol),Bis(trichloromethyl) carbonate 11.9 g (0.04 mol) and150 mL of ethyl acetate, magnetically stirred and heated to 35 C.0.3 g of triethylamine was added dropwise, and the reaction was kept at 50 C for 2 h after the addition.Until the bubble stops, the reaction solution is clarified by white turbidity.Then purge the residual hydrogen chloride and phosgene with nitrogen.Standby after cooling.

While traditionally a conservative industry, chemical producers will need to modernize their PR strategies to stay relevant.we look forward to future research findings about 137640-84-7, 6-(3-(Trifluoromethyl)phenoxy)picolinic acid.

Reference:
Patent; Hebei University; Li Wan; Yang Zihui; Yang Fenglin; (6 pag.)CN108794390; (2018); A;,
Pyridine – Wikipedia,
Pyridine | C5H5N – PubChem