Pyridine-derivatives

The major producers of chemicals have been the Europe, Japan and China. Due to the growing call for a cleaner, greener environment, people will have to find innovative ways to maintain their relevance. Here is a compound 58584-94-4, name is 2,6-Dichloro-3-methylpyridine. This compound has unique chemical properties. The synthetic route is as follows. category: pyridine-derivatives

Step 2. To 3-(tributylstannyl)-2-(trifluoromethyl)imidazo[l,2-a]pyridine (1.1 g, 2.31 mmol) was added the obtained product, dioxane (6 mL), QPhos (49 mg, 0.07 mmol) and Pd2dba3 (21 mg, 0.023 mmol). The mixture was heated at 110 C for one hour, then at 90 C for 15 hours. The product was concentrated and purified by chromatography on silica gel (gradient ethyl acetate :hexane 1:10 to 1:1) to provide a mixture of crude isomers: 3-(6- chloro-5-methylpyridin-2-yl)-2-(trifluoromethyl)imidazo[l,2-a]pyridine as a pink solid (58 mg, 8 ) and 3-(6-chloro-3-methylpyridin-2-yl)-2-(trifluoromethyl)imidazo[l,2-a]pyridine (more polar) (130 mg).

With the rapid development of chemical substances, we look forward to future research findings about 58584-94-4.

Reference:
Patent; PTC THERAPEUTICS, INC.; BAIAZITOV, Ramil; CHOI, Soongyu; DU, Wu; HWANG, Seongwoo; LEE, Chang-Sun; LIU, Ronggang; MOON, Young-Choon; PAGET, Steven, D.; REN, Hongyu; SYDORENKO, Nadiya; WILDE, Richard, Gerald; WO2015/76800; (2015); A1;,
Pyridine – Wikipedia,
Pyridine | C5H5N – PubChem

Reference of 20265-38-7, The major producers of chemicals have been the Europe, Japan and China. Due to the growing call for a cleaner, greener environment, people will have to find innovative ways to maintain their relevance. Here is a compound 20265-38-7, name is 2-Methoxypyridin-3-amine. This compound has unique chemical properties. The synthetic route is as follows.

General procedure: An oven-dried resealable Schlenk tube was charged with (S)-2-chloro-N-(1-(5-fluoropyridin-2-yl)ethyl)pyrimidin-4-amine (Preparation 1a, 43 mg, 0.17 mmol), 2-methoxypyridin-3-amine (23 mg, 0.19 mmol), cesium carbonate (111 mg, 0.34 mmol) and 1,4-dioxane (3 mL). The Schlenk tube was subjected to three cycles of evacuation-backfilling with argon then tris(dibenzylideneacetone)dipalladium(0) (16 mg, 0.02 mmol) and 9,9-dimethyl-4,5-bis(diphenylphosphino)xanthene (10 mg, 0.02 mmol) were added. After three further cycles of evacuation-backfilling with argon, the Schlenk tube was capped and then stirred and heated to 100 ºC. After 24 hours the mixture was cooled and the solvent was evaporated under reduced pressure. Ethyl acetate was added and the organic solution was washed with water (x3) and brine, dried (MgSO4) and the solvent evaporated under reduced pressure. The residue was purified by reverse phase chromatography (C-18 silica from Waters©, water/acetonitrile/methanol as eluents [0.1percent v/v formic acid buffered] 0percent to 100percent) to yield the title compound (11 mg, 19percent) as a solid.LRMS (m/z): 341 (M+1)+.

While traditionally a conservative industry, chemical producers will need to modernize their PR strategies to stay relevant.we look forward to future research findings about 20265-38-7, 2-Methoxypyridin-3-amine.

Reference:
Patent; Almirall, S.A.; Eastwood, Paul Robert; Bach Tana, Jordi; Pages Santacana, Lluis Miquel; EP2554544; (2013); A1;,
Pyridine – Wikipedia,
Pyridine | C5H5N – PubChem

Related Products of 100-70-9, As we all know, there are many different methods for the synthesis of a compound, and people can choose the synthesis method that suits their own laboratory according to the actual situation. 100-70-9, name is Picolinonitrile, molecular formula is C6H4N2, The compound is widely used in many fields, so it is necessary to find a new synthetic route. The downstream synthesis method of this compound is introduced below.

General procedure: a. Ground phosphoruspentasulfide (115 g, 0.5 mol) was added to asolution of 4-cyanopyridine (52 g, 0.5 mol) in 250 mLof 20% ammonium in methanol under vigorous stirringmaintaining the reaction mixture temperature below35-40C. The reaction mixture was kept at roomtemperature for 12 h, After the reactionended, 150 mL of water was added and the mixturewas heated up to 70-75C by water bath till the gasevolution stopped. After cooling the precipitate wasfiltered off, washed with water, and dried. Yield 89%(61.8 g), Rf 0.45, mp 137 (136-137 [21]). Found,%: 52.09; H 4.31; N 20.30; S 23.30. C6H6N2S.Calculated, %: 52.15; H 4.38; N 20.27; S 23.20.

According to the analysis of related databases, 100-70-9, the application of this compound in the production field has become more and more popular.

Reference:
Article; Khromova, N. Yu.; Malekin; Kutkin; Kondrat’Ev; Russian Journal of General Chemistry; vol. 85; 10; (2015); p. 2295 – 2298; Zh. Obshch. Khim.; vol. 85; 10; (2015); p. 1663 – 1666,4;,
Pyridine – Wikipedia,
Pyridine | C5H5N – PubChem

Each compound has different characteristics, and only by selecting the characteristics of the compound suitable for a specific situation can the compound be applied on a large scale. 918504-27-5, name is N-(3-(5-Bromo-1H-pyrrolo[2,3-b]pyridine-3-carbonyl)-2,4-difluorophenyl)propane-1-sulfonamide. This compound has unique chemical properties. The synthetic route is as follows. Quality Control of N-(3-(5-Bromo-1H-pyrrolo[2,3-b]pyridine-3-carbonyl)-2,4-difluorophenyl)propane-1-sulfonamide

General procedure: Aryl bromide (1 eq.), K2C03(2 eq.) and boronic acid / pinacol ester (1.2 eq.) were suspended in DME/H20 (0.15 m, 4:1 ) and degassed with argon for 10 min. Pd(PPh3)4(0.05 eq.) was added and the suspension, which was then irradiated at 130C for 30 min ^w). The resulting mixture was passed through a Celite pad and the solvent was removed under reduced pressure. The crude mixture was purified via flash chromatography (Si02, DCM/MeOH (content of MeOH increased in 0.5%-steps from 0 to 5% (v/v)) to yield the titled compound.

If you are interested in these compounds, you can also browse my other articles.Thank you for taking the time to read this article. I hope you enjoyed it, 918504-27-5, N-(3-(5-Bromo-1H-pyrrolo[2,3-b]pyridine-3-carbonyl)-2,4-difluorophenyl)propane-1-sulfonamide.

Reference:
Patent; HEPAREGENIX GMBH; ALBRECHT, Wolfgang; LAUFER, Stefan; SELIG, Roland; KLOeVEKORN, Phillip; PRAeFKE, Bent; (121 pag.)WO2018/134254; (2018); A1;,
Pyridine – Wikipedia,
Pyridine | C5H5N – PubChem

The major producers of chemicals have been the Europe, Japan and China. Due to the growing call for a cleaner, greener environment, people will have to find innovative ways to maintain their relevance. Here is a compound 926293-55-2, name is 6-Bromo-2-methylnicotinaldehyde. This compound has unique chemical properties. The synthetic route is as follows. HPLC of Formula: C7H6BrNO

A mixture of 6-chloro-2-methyl-pyridine-3-carbaldehyde (715 mg, 4.60 mmol), methyl 4-hydroxyphenylacetate (694 mg, 4.18 mmol) and K2CO3 (404 mg, 2.92 mmol) in DMF (8.4 mL) was heated to 130 0C for 1 h then filtered and concentrated. The residue was dissolved in EtOAc (40 mL) and washed with brine (3 x 10 mL) then dried (MgSO4) and EPO concentrated. Purification by chromatography on silica gel (30% EtOAc/hexanes) gave [4-(5- formyl-6-methyl-pyridin-2-yloxy)-phenyl]-acetic acid methyl ester as a yellow oil (687 mg, 58%). 1H NMR (CDCl3) delta 2.75 (s, 3H)5 3.66 (s, 2H), 3.73 (s, 3H), 6.76 (d, IH, J= 8.7 Hz), 7.13 (d, 2H, J= 8.7 Hz), 7.34 (d, 2H, J= 8.7 Hz), 8.09 (d, IH, J= 8.4 Hz), 10.24 (s, IH).

With the rapid development of chemical substances, we look forward to future research findings about 926293-55-2.

Reference:
Patent; ANORMED INC.; WO2007/22371; (2007); A2;,
Pyridine – Wikipedia,
Pyridine | C5H5N – PubChem

Related Products of 36052-27-4, Adding some certain compound to certain chemical reactions, such as: 36052-27-4, name is Methyl 3-aminopicolinate,molecular formula is C7H8N2O2, can increase the reaction rate and produce products with better performance than those obtained under traditional synthetic methods. Here is a downstream synthesis route of the compound 36052-27-4.

A solution of methyl 3-aminopyridine-2-carboxylate (1 g, 6.57 mmol, 1.00 equiv) and N-bromosuccinimide (1.29 g, 7.25 mmol, 1.10 equiv) in acetonitrile (25 mL) was stirred at room temperature. After being stirred for 2 h the mixture was concentrated under vacuum. The residue was applied onto a silica gel column with ethyl acetate/petroleum ether (2:1) to give the title compound (0.81 g, 54%) as a yellow solid. LC-MS (ES, m/z): 231, 233 [M+H]+.

In the field of chemistry, the synthetic routes of compounds are constantly being developed and updated. I will also mention this compound in other articles. 36052-27-4, Methyl 3-aminopicolinate, other downstream synthetic routes, hurry up and to see.

Reference:
Patent; Genentech, Inc.; Blaquiere, Nicole; Castanedo, Georgette; Feng, Jianwen A.; Hu, Baihua; Staben, Steven; Yuen, Po-wai; Wu, Guosheng; Lin, Xingyu; Burch, Jason; US2015/57260; (2015); A1;,
Pyridine – Wikipedia,
Pyridine | C5H5N – PubChem

Application of 72830-09-2, Adding some certain compound to certain chemical reactions, such as: 72830-09-2, name is 2-Chloromethyl-3,4-dimethoxypyridinium chloride,molecular formula is C8H11Cl2NO2, can increase the reaction rate and produce products with better performance than those obtained under traditional synthetic methods. Here is a downstream synthesis route of the compound 72830-09-2.

Example 1 : Preparation of Pantoprazole Sodium2-Mercapto-5-difluoromethoxy benzimidazole (50 g) was added to an aqueous solution of sodium hydroxide (21.3 g in 350 mL de-ionized water) at room temperature to obtain a clear solution. An aqueous solution of 2-chloromethyl-3, 4-dimethoxypyridine hydrochloride (50 g in 150 mL water) was added to the above solution over a period of about 2.0-2.5 hours. The reaction mixture was stirred vigorously for about 2-2.5 hours. Progress of the reaction was monitored by thin-layer chromatography. The reaction mixture was extracted with dichloromethane and washed with water. Organic layer was concentrated. Methanol (50 mL) was added to the organic layer. The reaction mixture was cooled to -5 to -200C. Aqueous solution of sodium hydroxide (11.8 g in 50 mL water) was added followed by addition of sodium hypochlorite solution (431 mL) in an aqueous solution of sodium hydroxide (20 g/ 100 mL) over a period of about 30 to about 45 minutes. The progress of the reaction was monitored by thin-layer chromatography. After completion of the reaction, the reaction mixture was quenched with 5% sodium hydrogen sulphite solution (500 mL). Water (500 mL) was added. pH of the reaction mixture was adjusted to 9.0-10.5. Layers were separated and the aqueous layer was extracted with dichloromethane. The combined dichloromethane layers were concentrated completely to obtain a red-brown colored residue.The residue was dissolved in acetone (375 mL). The reaction mixture was cooled to 20-250C. Aqueous solution of sodium hydroxide (9.2 g in 25 mL water) was added followed by addition of a seed crystal of pantoprazole sodium. The reaction mixture was stirred, cooled, stirred, filtered and washed with cold acetone to obtain crude pantoprazole sodium as a wet cake.

In the field of chemistry, the synthetic routes of compounds are constantly being developed and updated. I will also mention this compound in other articles. 72830-09-2, 2-Chloromethyl-3,4-dimethoxypyridinium chloride, other downstream synthetic routes, hurry up and to see.

Reference:
Patent; RANBAXY LABORATORIES LIMITED; WO2009/10937; (2009); A1;,
Pyridine – Wikipedia,
Pyridine | C5H5N – PubChem

Each compound has different characteristics, and only by selecting the characteristics of the compound suitable for a specific situation can the compound be applied on a large scale. 1195-59-1, name is 2,6-Pyridinedimethanol. This compound has unique chemical properties. The synthetic route is as follows. Product Details of 1195-59-1

At 0 C, a solution of p-toluenesulfonyl chloride (0.76 g,4.0 mmol) in tetrahydrofuran (THF; 7.5 mL) was added to a stirred solution of 2,6-pyridinedimethanol (0.28 g, 2.0 mmol) and NaOH (0.8 g, 20 mmol) in THF/water (7.5/7.5 mL). After 4 h of stirring, the mixture was poured into 20 mL of water and extracted with methylene chloride (3 × 7.5 mL). The organic phase was washed with saturated aqueous NaCl solution and distilled water and dried over Na2SO4; the solvent was removed in vacuo to afford 2,6-pyridinedimethylene ditosylate (0.79 g, 88%) as a white powder. 1H NMR(300 MHz, CDCl3): = 7.80 (d, J = 7.5 Hz, 4H, 2,6-H tosyl), 7.69 (t,J = 7.5 Hz, 1H, 4-H Py), 7.32 (d, 2H, 3,5-H Py, d, 4H, 3,5-H tosyl), 5.04(s, 4H, PyCH2tosyl), and 2.44 (s, 6H, tosyl-CH3)

If you are interested in these compounds, you can also browse my other articles.Thank you for taking the time to read this article. I hope you enjoyed it, 1195-59-1, 2,6-Pyridinedimethanol.

Reference:
Article; Woo, Jeong Oh; Kang, Sung Kwon; Park, Jong-Eun; Son, Kyung-Sun; Journal of Molecular Catalysis A: Chemical; vol. 404-405; (2015); p. 204 – 210;,
Pyridine – Wikipedia,
Pyridine | C5H5N – PubChem

Reference of 13472-85-0 ,Some common heterocyclic compound, 13472-85-0, molecular formula is C6H6BrNO, its traditional synthetic route has been very mature, but the traditional synthetic route has various shortcomings, such as complicated route, low yield, poor purity, etc., below Introduce a new synthetic route.

To a solution of diispropylamine (63 g, 642 mmol) in anhydrous THF (500 ml) was added n-BuLi5 (2.5 M, in hexane, 256 mL, 642 mmol) dropwise under a N2 atmosphere at -78 C, and themixture was stirred for 30 min. To the reaction mixture was added a solution of 5-bromo-2-methoxypyridine (100 g, 535 mmol) in 100 mL ofTHF. The reaction mixture was stirred at-78 oc for 1h, and then DMF (50 ml, 642 mmol) was added. After stirring for 30 min, the reactionmixture was quenched with water and extracted with EtOAc. The organic layer was washed with10 water and brine, and dried over Na2S04. After filtration and concentration, the residue waspurified by silica gel column chromatography (eluted with petroleum ether: ethyl acetate= 10: 1) togive solid 39-1. MS(ESI) m/e (M+H+): 216.0/218.0.

These compound has a wide range of applications. It is believed that with the continuous development of the source of the synthetic route,13472-85-0, its application will become more common.

Reference:
Patent; MERCK SHARP & DOHME CORP.; HAGMANN, William K.; NARGUND, Ravi P.; BLIZZARD, Timothy A.; JOSIEN, Hubert; BIJU, Purakkattle; PLUMMER, Christopher W.; DANG, Qun; LI, Bing; LIN, Linus S.; CUI, Mingxiang; HU, Bin; HAO, Jinlai; CHEN, Zhengxia; WO2014/19186; (2014); A1;,
Pyridine – Wikipedia,
Pyridine | C5H5N – PubChem

Application of 2176-62-7, Researchers who often do experiments know that organic synthesis is a process of preparing more complex target molecules from simple raw materials through one or more chemical reactions. Generally, it requires fewer steps,and cheap raw materials. 2176-62-7, name is Perchloropyridine. A new synthetic method of this compound is introduced below.

EXAMPLE II — 2,3,5-Trichloropyridine To a 500 milliliter, 3-neck flask which was fitted with a reflux condenser, heater, thermometer and stirrer was added 200 milliliters (1.2 moles) of 6N ammonium hydroxide, 39.0 grams (0.60 gram atom) of zinc dust, 100 milliliters of toluene and 25.1 grams (0.1 mole) of pentachloropyridine. The pH of the mixture was 12.6. The mixture was heated to 70 C., with stirring, and held under these conditions for 35 hours. At the end of this period, the reaction mixture was cooled to 20 C. and filtered to remove insolubles. The filter cake was washed with toluene and the toluene combined with the filtrate and concentrated by distillation. Analysis indicated a 2,3,5-trichloropyridine yield of 9.39 grams (52 percent of theoretical).

These compound has a wide range of applications. It is believed that with the continuous development of the source of the synthetic route,2176-62-7, its application will become more common.

Reference:
Patent; The Dow Chemical Company; US4111938; (1978); A;,
Pyridine – Wikipedia,
Pyridine | C5H5N – PubChem