Tag: M.W:100-200

Related Products of 29681-43-4, With the rapid development and complex challenges of chemical substances, the synthesis of new drugs is usually one of the most effective ways to increase yield.29681-43-4, name is Methyl 4-methoxypyridine-2-carboxylate, molecular formula is C8H9NO3, molecular weight is 167.16, as common compound, the synthetic route is as follows.

b) Lithium aluminum hydride (16 ml of a 1.0 N solution in diethyl ether, 16 mmol) was added to a solution of methyl 4-methoxypicoline-2-carboxylate (2.70 g, 16 mmol) in diethyl ether (50 ml) at ambient temperature. The reaction was stirred for 1 hour, poured into an aqueous solution of Rochelle’s salt (250 ml) and the reaction mixture extracted with ethyl acetate (3*50 ml). Purification of the crude product by flash chromatography on silica gel, eluding with dichloromethane-ethyl acetate, yielded 2-(hydroxymethyl)-4-methoxypyridine (800 mg, 36% yield) as a white solid.

The chemical industry reduces the impact on the environment during synthesis 29681-43-4, I believe this compound will play a more active role in future production and life.

Reference:
Patent; AstraZeneca AB; US7081461; (2006); B1;,
Pyridine – Wikipedia,
Pyridine | C5H5N – PubChem

Electric Literature of 499-51-4, Researchers who often do experiments know that organic synthesis is a process of preparing more complex target molecules from simple raw materials through one or more chemical reactions. Generally, it requires fewer steps,and cheap raw materials. 499-51-4, name is 4-Hydroxypyridine-2,6-dicarboxylic acid. A new synthetic method of this compound is introduced below.

15 g of monohydric chelidamic acid (0.075 mol, I eq.) are dissolved in 120 mE of thionyl chloride under argon. The suspension is cooled to 00 C. and 3 mE DMF are added. The reaction mixture is then stirred for 12 hours with reflux. Volatiles are evaporated afier several toluene additions to remove the last traces of SOd2. The resulting yellowish solid is then dissolved in methanol and the mixture is refluxed for 12 hours to complete the reaction. After evaporation of the solvent, the residue is taken up by dichloromethane and washed successively with a saturated solution of NaHCO3, water and brine. The organic phase is then dried on Na2SO4, filtered and evaporated. Pure compound 12 is obtained by recrystallization in methanol to obtain 8.3of white crystalline powdet (R=44%). ?H-NMR (300 MHz, CDC13) oe (ppm)=8.29 (s,2H), 4.03 (s, 6H).

These compound has a wide range of applications. It is believed that with the continuous development of the source of the synthetic route,499-51-4, its application will become more common.

Reference:
Patent; ECOLE NORMALE SUPERIEURE DE LYON; CENTRE NATIONAL DE LA RECHERCHE SCIENTIFIQUE; UNIVERSITE CLAUDE BERNARD LYON I; COMMISSARIAT A L’ENERGIE ATOMIQUE ET AUX ENERGIES ALTERNATIVES; MAURY, Oliver; GIRARD, Eric; ENGILBERGE, Sylvain; RIOBE, Francois; (76 pag.)US2018/362550; (2018); A1;,
Pyridine – Wikipedia,
Pyridine | C5H5N – PubChem

Researchers who often do experiments know that organic synthesis is a process of preparing more complex target molecules from simple raw materials through one or more chemical reactions. Generally, it requires fewer steps,and cheap raw materials. 13466-38-1, name is 5-Bromopyridin-2-ol. A new synthetic method of this compound is introduced below., Formula: C5H4BrNO

Synthesis of 5-bromo-2-(2-methoxyethoxy)pyridineTo a solution of 5-bromopyridin-2-ol (5.75 mmol, lg), triphenylphosphine (8.62mmol, 2.26 g), and 2-methoxyethanol (7.2 mmol, 0.55 g) in THF (25 mL), was added slowly diisopropyl azodicarboxylate (8.62 mmol, 1.7 mL) at RT. The mixture was stirred at RT overnight. The reaction was quenched with MeOH, diluted with water and extracted with DCM (25 mL). The organic layer was washed with water, dried over anhydrous sodium sulfate and concentrated in vacuo. Crude was purified by flash chromatography (cyclohexane/EtOAc = 9/2 -> 7/3) to yield title product. Y: 1.05 g (79%), P>80%, rt=3.9 min (gradient A), (M+H)+ = 233.

If you are interested in these compounds, you can also browse my other articles.Thank you for taking the time to read this article. I hope you enjoyed it, 13466-38-1, 5-Bromopyridin-2-ol.

Reference:
Patent; EUROSCREEN S.A.; HOVEYDA, Hamid; DUTHEUIL, Guillaume; EL BOUSMAQUI, Mohamed; BERNARD, Jerome; WO2011/151434; (2011); A1;,
Pyridine – Wikipedia,
Pyridine | C5H5N – PubChem

Application of 87394-65-8 , The common heterocyclic compound, 87394-65-8, name is 1-(5-Chloro-2-pyridyl)piperazine, molecular formula is C9H12ClN3, its traditional synthetic route has been very mature, but the traditional synthetic route has various shortcomings, such as complicated route, low yield, poor purity, etc., below Introduce a new synthetic route.

To a solution of triphosgene (300 mg) in CH2CI2 (5 mL) was added 1- phenylpiperidin-4-ol (352 mg, 1.99 mmol) over 3 hr, followed by the addition of a solution of 5-[(tert-butyldimethylsilyl)oxy]pyridin-2-amine (448 mg, 2.00 mmol, 1.00 eq) in pyridine (1 mL) over 16 hr. The resulting solution was stirred an additional 16 h at rt, then extracted with 2×30 mL of CH2CI2. The combined organic layers were concentrated under vacuum and purified with silica gel chromatography using CH2CI2 / MeOH (20: 1) to afford 270 mg (32%) of the title compound as an off-white solid. LC-MS: (ES, m/z) 428.

The synthetic route of 87394-65-8 has been constantly updated, and we look forward to future research findings.

Reference:
Patent; CENTAURUS THERAPEUTICS; ROMERO, Donna, L.; BLITZER, Jeremy; (242 pag.)WO2019/140188; (2019); A1;,
Pyridine – Wikipedia,
Pyridine | C5H5N – PubChem

With the rapid development and complex challenges of chemical substances, the synthesis of new drugs is usually one of the most effective ways to increase yield.884494-34-2, name is 2-Ethynyl-5-fluoropyridine, molecular formula is C7H4FN, molecular weight is 121.11, as common compound, the synthetic route is as follows.category: pyridine-derivatives

Step 3: Preparation of ethyl 5-(5-fluoropyridin-2-yl)isoxazole-3-carboxylate To a solution of 2-ethynyl-5-fluoropyridine (1.5 g, 12.4 mmol) in N,N-dimethylformamide (20 mL) at 23 C. was added (Z)-Ethyl 2-chloro-2-(hydroxyimino)acetate (2.81 g, 18.6 mmol). The reaction mixture stirred for 1 h before triethylamine (1.88 g, 18.6 mmol) was added. The mixture was heated at 90 C. for 16 h. The mixture was diluted with brine (100 mL), extracted with ethyl acetate (100 mL*2) and purified by column chromatography (silica, petroleum ether/ethyl acetate=20/1) to give ethyl 5-(5-fluoropyridin-2-yl)isoxazole-3-carboxylate (300 mg, 1.27 mmol, 10%) as a gray oil. LCMS (ESI) m/z: 237.1 [M+H]+.

At the same time, in my other blogs, there are other synthetic methods of this type of compound,884494-34-2, 2-Ethynyl-5-fluoropyridine, and friends who are interested can also refer to it.

Reference:
Patent; Yumanity Therapeutics, Inc.; WRONA, Iwona; TIVITMAHAISOON, Parcharee; TARDIFF, Daniel; PANDYA, Bhaumik; OZBOYA, Kerem; LUCAS, Matthew; BOURDONNEC, Bertrand Le; (259 pag.)US2019/330198; (2019); A1;,
Pyridine – Wikipedia,
Pyridine | C5H5N – PubChem

Adding a certain compound to certain chemical reactions, such as: 10165-86-3, Methyl 6-formylnicotinate, can increase the reaction rate and produce products with better performance than those obtained under traditional synthetic methods. Here is a downstream synthesis route of the compound, 10165-86-3, blongs to pyridine-derivatives compound. COA of Formula: C8H7NO3

A mixture of methyl 6-formylnicotinate (1.000 g, 6.055 mmol) and 3-chloro-4-fluoroaniline (0.970 g, 6.66 1 mmol) in tetrahydrofuran (50 mL) was stuffed at the room temperature for 30 mm, and treated with sodium triacetoxyborohydride (1.925 g, 9.083 mmol). The reaction mixture was stuffed at the same temperature for additional 18 hr. Then, saturated aqueous sodium bicarbonate solution was added to the reaction mixture, followed by extraction with ethyl acetate. The organic layer was washed with aqueous saturated sodium chloride solution, dried with anhydrous MgSO4, filtered, and concentrated in vacuo. The residue was chromatographed (Si02, 40 g cartridge; ethyl acetate / dichloromethane = 0 percent to 5 percent) to give methyl6-(((3-chloro-4-fluorophenyl)amino)methyl)nicotinate as brown solid (0.510 g, 28.6percent).

These compound has a wide range of applications. It is believed that with the continuous development of the source of the synthetic route,10165-86-3, its application will become more common.

Reference:
Patent; CHONG KUN DANG PHARMACEUTICAL CORP.; LEE, Jaekwang; HAN, Younghue; KIM, Yuntae; CHOI, Daekyu; MIN, Jaeki; BAE, Miseon; YANG, Hyunmo; KIM, Dohoon; (644 pag.)WO2017/18803; (2017); A1;,
Pyridine – Wikipedia,
Pyridine | C5H5N – PubChem

As we all know, there are many different methods for the synthesis of a compound, and people can choose the synthesis method that suits their own laboratory according to the actual situation. 5345-47-1, name is 2-Aminonicotinic acid, molecular formula is C6H6N2O2, The compound is widely used in many fields, so it is necessary to find a new synthetic route. The downstream synthesis method of this compound is introduced below. COA of Formula: C6H6N2O2

2-Aminonicotinic acid (10.00 g, 72.40 mmol) was suspended in 40 ml of glacial acetic acid. To this suspension was added dropwise a solution of 4.82 ml (94.12 mmol) of bromine in 20 ml of glacial acetic acid. The mixture was stirred vigorouly at room temperature for 30 min. The formed precipitate was filtered off and washed with glacial acetic acid. The filter cake was collected and crystallized from the boiling methol to afford compound 8 as a white solid (14.5 g, 92% yield). 1H NMR (300 MHz, DMSO-d6) delta 8.30 (d, J = 2.4 Hz, 1H), 8.16 (d, J = 2.4 Hz, 1H); MS (ESI, m/z): 216.8 [M+H]+.

With the rapid development of chemical substances, we look forward to future research findings about 5345-47-1.

Reference:
Article; Zhang, Dengyou; Ai, Jing; Liang, Zhongjie; Li, Chunpu; Peng, Xia; Ji, Yinchun; Jiang, Hualiang; Geng, Meiyu; Luo, Cheng; Liu, Hong; Bioorganic and Medicinal Chemistry; vol. 20; 17; (2012); p. 5169 – 5180;,
Pyridine – Wikipedia,
Pyridine | C5H5N – PubChem

Reference of 17228-69-2, Researchers who often do experiments know that organic synthesis is a process of preparing more complex target molecules from simple raw materials through one or more chemical reactions. Generally, it requires fewer steps,and cheap raw materials. 17228-69-2, name is 2-Chloro-4-methoxypyridine. A new synthetic method of this compound is introduced below.

Ethanolamine (4.0 ml) was added to potassium tert-butoxide (96 ml of a 1M solution in THF) and the reaction was stirred at room temperature for 30 min. 2-Chloro-4- methoxypyridine was added dropwise and the reaction mixture was heated under reflux for 16 h. The reaction mixture was cooled, filtered and evaporated to an oil. This was dissolved in xylene (100 ml) and treated with toluene-4-sulphonic acid (50 mg) and heated under reflux for 16 h. More toluene-4-sulphonic acid (50 mg) was added and the heating was continued for a further 16 h under reflux. The mixture was concentrated, the residue was passed through a pad of silica and eluted with 5% 7M ammonia in methanol/DCM to give the sub-title compound as a brown oil (5.0 g). MS APCI +VE/Z 169 ([M+H]). 1H NMR 300MHz (DMSO-d6) 7.76 (1H, d), 6.33 (1H, t), 6.13-6. 10 (1H, m), 5.99 (1H, m), 3.70 (3H, s), 3.54-3. 47 (2H, m), 3.31-3. 25 (2H, m).

At the same time, in my other blogs, there are other synthetic methods of this type of compound,17228-69-2, 2-Chloro-4-methoxypyridine, and friends who are interested can also refer to it.

Reference:
Patent; ASTRAZENECA AB; WO2004/87666; (2004); A1;,
Pyridine – Wikipedia,
Pyridine | C5H5N – PubChem

Synthetic Route of 586-95-8 ,Some common heterocyclic compound, 586-95-8, molecular formula is C6H7NO, its traditional synthetic route has been very mature, but the traditional synthetic route has various shortcomings, such as complicated route, low yield, poor purity, etc., below Introduce a new synthetic route.

(IV) 4-Chloromethylpyridine hydrochloride (19) STR16 4-Hydroxymethylpyridine (18) 54.4 g (0.50 mol) was dissolved in acetonitrile 202 ml. The solution was added dropwise to the mixture of thionyl chloride 65.3 g (0.55 mol) and acetonitrile 109 ml under 50 C. The mixture was stirred at the same temperature for 1 hour, then cooled to room temperature to yield the slurry (quantitative) of the objective (19). 1 H-NMR (DMSO-TMS) delta ppm: 5.09 (s, 2H), 8.09 (d, J=6.6 Hz, 2H), 8.94 (d, J=6.6 Hz, 2H),

These compound has a wide range of applications. It is believed that with the continuous development of the source of the synthetic route,586-95-8, its application will become more common.

Reference:
Patent; Shionogi & Co., Ltd.; US6057448; (2000); A;,
Pyridine – Wikipedia,
Pyridine | C5H5N – PubChem

Application of 164666-68-6, As we all know, there are many different methods for the synthesis of a compound, and people can choose the synthesis method that suits their own laboratory according to the actual situation. 164666-68-6, name is 6-Chloro-2-methylpyridin-3-amine, molecular formula is C6H7ClN2, The compound is widely used in many fields, so it is necessary to find a new synthetic route. The downstream synthesis method of this compound is introduced below.

Step 2: 6-Chloro-N-isopropyl-2-methylpyridin-3-amine (45). To a stirred solution of 44 (4.81 g, 33.75 mmol) and acetone (2.74 g, 47.2 mmol) in dichloroethane (60 mL) was added NaBH(OAc)3 (10.713 g, 50.53 mmol) and AcOH (3.44 g, 57.2 mmol) at RT. The reaction was stirred for 16 h followed by dilution with IN NaOH. The aqueous solution was extracted with DCM and the organic layer was washed with water, brine, dried over Na2S04 and concentrated to afford 45 (6.16 g, 98%).

According to the analysis of related databases, 164666-68-6, the application of this compound in the production field has become more and more popular.

Reference:
Patent; EXELIXIS, INC.; XU, Wei; (106 pag.)WO2017/4608; (2017); A1;,
Pyridine – Wikipedia,
Pyridine | C5H5N – PubChem