Tag: M.W:100-200

Related Products of 68618-36-0, The major producers of chemicals have been the Europe, Japan and China. Due to the growing call for a cleaner, greener environment, people will have to find innovative ways to maintain their relevance. Here is a compound 68618-36-0, name is 3-Bromo-1H-pyrazolo[3,4-b]pyridine. This compound has unique chemical properties. The synthetic route is as follows.

To a solution of 3-bromo-1H-pyrazolo[3,4-b]pyridine (200 mg, 1.010 mmol), zinc cyanide (1.0 eq., 121.0 mg, 1.010 mmol), tris(dibenzylideneacetone)dipalladium(0) (0.04 eq., 38.1 mg, 0.040 mmol), 1,1?-bis(diphenylphosphino)feffocene (0.08 eq., 46.6 mg, 0.08 1 mmol) and zinc (0.24 eq., 15.8 mg, 0.242 mmol) were dissolved in degassed N,N-dimethylacetamide (5.0 mL) under inert atmosphere. The reaction was heated to 120 C for 5 hours. The reaction was then diluted withaqueous saturated sodium bicarbonate and extracted 2 times with dichloromethane. The organics were combined, washed with brine, dried with sodium sulfate and concentrated under vacuum. The crude material was crashed out in diethyl ether to afford 93 mg of the title compound (64 %).

According to the analysis of related databases, 68618-36-0, the application of this compound in the production field has become more and more popular.

Reference:
Patent; F. HOFFMANN-LA ROCHE AG; GENENTECH, INC.; BLAQUIERE, Nicole; BURCH, Jason; CASTANEDO, Georgette; FENG, Jianwen A.; HU, Baihua; STABEN, Steven; WU, Guosheng; YUEN, Po-wai; WO2015/25025; (2015); A1;,
Pyridine – Wikipedia,
Pyridine | C5H5N – PubChem

The major producers of chemicals have been the Europe, Japan and China. Due to the growing call for a cleaner, greener environment, people will have to find innovative ways to maintain their relevance. Here is a compound 16133-25-8, name is Pyridine-3-sulfonyl chloride. This compound has unique chemical properties. The synthetic route is as follows. HPLC of Formula: C5H4ClNO2S

To a solution of (6-phenylpyridazin-3-ylmethyl)amine hydrochloride (121 mg) (containing 0.458 mmol of a pure content) obtained in Reference Example 2-(c) in methylene chloride (1 ml) were added triethylamine (0.26 ml, 1.8 mmol) and 3-pyridylsulfonyl chloride (see The Journal of Organic Chemistry, 54, 389 (1989)) (83.2 mg, 0.468 mmol), followed by stirring at room temperature for 17 hours. After completion of the reaction, the reaction solution was concentrated under reduced pressure, and water was added to the residue, followed by extraction with ethyl acetate. The separated organic layer was washed with a saturated aqueous sodium chloride solution, dried over anhydrous sodium sulfate, and then concentrated under reduced pressure. The resulting residue was subjected to silica gel column chromatography (eluent; ethyl acetate_acetonitrile=1:00:1 (V/V), then chloroform), and fractions containing the desired compound were concentrated under reduced pressure to afford the title compound (130 mg) as a slightly brown solid. (Yield: 87percent) Mass spectrum (CI, m/z): 327 (M++1). 1H-NMR spectrum (CDCl3, ppm): 9.11 (dd, J=2.4, 0.9Hz, 1H), 8.75 (dd, J=4.8, 1.6Hz, 1H), 8.19 (ddd, J=8.1, 2.4, 1.6Hz, 1H), 8.05-8.00 (m, 2H), 7.82 (d, J=8.8Hz, 1H), 7.56-7.49 (m, 4H), 7.42 (ddd, J=8.1, 4.8, 0.9Hz, 1H), 6.30 (brs, 1H), 4.57 (s, 2H).

With the rapid development of chemical substances, we look forward to future research findings about 16133-25-8.

Reference:
Patent; Ube Industries, Ltd.; EP2264009; (2010); A1;,
Pyridine – Wikipedia,
Pyridine | C5H5N – PubChem

In the next few decades, the world population will flourish. As the population grows rapidly and people all over the world use more and more resources, all industries must consider their environmental impact. 175358-01-7, name is 3-Amino-6-chloropicolinamide, the common compound, a new synthetic route is introduced below. name: 3-Amino-6-chloropicolinamide

3-amino-6-chloro-pyridine-2-carboxylic acid amide (94 mg, 0.55 mmol) is taken up in cone. HCl (0.5 mL) and heated to 1100C for 5 h. Then the solvent is removed and 3- amino-6-chloro-pyridine-2-carboxylic acid is obtained.

The synthetic route of 175358-01-7 has been constantly updated, and we look forward to future research findings.

Reference:
Patent; BOEHRINGER INGELHEIM INTERNATIONAL GMBH; ENGELHARDT, Harald; BOEHMELT, Guido; KOFINK, Christiane; KUHN, Daniel; McCONNELL, Darryl; STADTMUELLER, Heinz; WO2010/7114; (2010); A2;,
Pyridine – Wikipedia,
Pyridine | C5H5N – PubChem

Reference of 56622-54-9, Researchers who often do experiments know that organic synthesis is a process of preparing more complex target molecules from simple raw materials through one or more chemical reactions. Generally, it requires fewer steps,and cheap raw materials. 56622-54-9, name is (6-Methylpyridin-3-yl)methanamine. A new synthetic method of this compound is introduced below.

Into a round-bottom flask were charged 3-(5-methylpyridin-2-yl)-5-(pyrrolidine-l – carbonyl)benzoic acid (80 mg, 0.26 mmol), (6-methylpyridin-3-yl)methanamine (60 mg, 0.49 mmol), N- (3-dimethylaminopropyl)-N’-ethylcarbodiimide hydrochloride (90 mg, 0.47 mmol), 1- hydroxybenzotriazole hydrate (80 mg, 0.52 mmol), NN-diisopropylethylamine (80 mg, 0.62 mmol) and methylene chloride (5 mL). The mixture was stirred at room temperature overnight and then concentrated. The residue was purified via preparative HPLC to afford the desired product as a white solid.LC-MS: 415.5 [M+l]+; 1H NMR (400 MHz, CD3OD): 8.56 (t, J = 1.7 Hz, IH), 8.53-8.52 (m, IH), 8.46 (d, J = 2.1 Hz, IH), 8.29 (t, J = 1.6 Hz, IH), 8.04 (t, J = 1.6 Hz, IH), 7.89 (d, J = 8.1 Hz, IH), 7.81-7.77 (m, 2H), 7.32 (d, J = 8.0 Hz, IH), 4.63 (s, 2H), 3.66 (t, J = 7.0 Hz, 2H), 3.54 (t, J = 6.7 Hz, 2H), 2.54 (s, 3H),2.43 (s, 3H), 2.05-1.94 (m, 4H).

These compound has a wide range of applications. It is believed that with the continuous development of the source of the synthetic route,56622-54-9, its application will become more common.

Reference:
Patent; RENOVIS, INC.; WO2009/110985; (2009); A2;,
Pyridine – Wikipedia,
Pyridine | C5H5N – PubChem

Reference of 573675-27-1 , The common heterocyclic compound, 573675-27-1, name is 3-Amino-5-bromopicolinonitrile, molecular formula is C6H4BrN3, its traditional synthetic route has been very mature, but the traditional synthetic route has various shortcomings, such as complicated route, low yield, poor purity, etc., below Introduce a new synthetic route.

Step 2A mixture of compound K2 (1 g, 5.05 mmol) and sodium acetate (829 mg, 10.1 mmol) in formic acid (50 mL) was stirred at reflux overnight, and then concentrated. Sodium hydroxide (3M) was added to the residue; the mixture was stirred for 10 min and filtered. The solid was washed with water and resuspended in hydrochloride (3M), stirred for another 10 min. The solid was collected and dried to give compound K3 (0.8 g). MS for K3: m/e = 226 and 228 (M+l).

The synthetic route of 573675-27-1 has been constantly updated, and we look forward to future research findings.

Reference:
Patent; MERCK SHARP & DOHME CORP.; WU, Wen-Lian; HE, Shuwen; WALSH, Shawn, P.; CUMMING, Jared, N.; (70 pag.)WO2016/118404; (2016); A1;,
Pyridine – Wikipedia,
Pyridine | C5H5N – PubChem

Adding a certain compound to certain chemical reactions, such as: 19798-77-7, 4-Amino-3-chloropyridine, can increase the reaction rate and produce products with better performance than those obtained under traditional synthetic methods. Here is a downstream synthesis route of the compound, name: 4-Amino-3-chloropyridine, blongs to pyridine-derivatives compound. name: 4-Amino-3-chloropyridine

In a second step, the first step of the product 2- [1- (2-methylbutyl) -1H-indol-3-yl] acetic acid was added to dichloromethane(20 mL) and stirred at room temperature. EDCI (1.27 g) (10g) wasstirred for 10 min, and the organic phase was added to saturated brine(10 mL), and the mixture was stirred at room temperature for 3 h.The organic phase was separated by column chromatography and eluted with ethyl acetate-petroleum ether (1: 3) to giveN- (3-chloropyridin-4-yl) -2- [1- (Methylbutyl) -1H-indol-3-yl] acetamide (1.4 g).

At the same time, in my other blogs, there are other synthetic methods of this type of compound,19798-77-7, 4-Amino-3-chloropyridine, and friends who are interested can also refer to it.

Reference:
Patent; Chinese Academy Of Medical Sciences Pharmaceutical Institute; Shi Jiangong; Guo Ying; Xu Chengbo; Ba Mingyu; Chen Minghua; Chen Qing; Zhu Chenggen; Tang Ke; Jiang Jiandong; Guo Jiamei; Guo Qinglan; Lin Sheng; Yang Yongchun; (44 pag.)CN107174581; (2017); A;,
Pyridine – Wikipedia,
Pyridine | C5H5N – PubChem

As we all know, there are many different methods for the synthesis of a compound, and people can choose the synthesis method that suits their own laboratory according to the actual situation. 19524-06-2, name is 4-Bromopyridine hydrochloride, molecular formula is C5H5BrClN, The compound is widely used in many fields, so it is necessary to find a new synthetic route. The downstream synthesis method of this compound is introduced below. Recommanded Product: 19524-06-2

General procedure: In a 10-mL glass tube were placed halide (1.0mmol); 2-formylphenyl or 2-pyridyl MIDA boronate (1.5mmol) or allyl MIDA boronate; K2CO3 (3.0 mmol); Pd EnCat30(6mol%); and ethanol/H2O (4:1v/v) or water, and a magnetic stir bar. The vessel was sealed with a septum and placed into the microwave cavity. The temperature was ramped from rt to 120C or 135C. Once the reaction temperature was reached, the reaction mixture was held at this temperature for 10-18 min. After the mixture was allowed to cool to room temperature, the reaction vessel was opened and the contents were poured into a separating funnel. Water and ethylacetate (3×10mL) were added. The combined organics were dried over Na2SO4, filtered, and concentrated in vacuo. The organic residue was adsorbed onto silicagel, and then purified by column flash chromatography (hexane = ethyl acetate as eluent) to afford the desired product 1a-x. The biaryls, bipyridines, or allylphenols prepared are known compounds. [23-45] The products were confirmed by comparing the 1H NMR and mass spectral data with authentic samples reported in the literature.

With the rapid development of chemical substances, we look forward to future research findings about 19524-06-2.

Reference:
Article; Da Silva, Joaquim F. M.; Yepes Perez, Andres F.; De Almeida, Natalia P.; Synthetic Communications; vol. 45; 17; (2015); p. 1995 – 2004;,
Pyridine – Wikipedia,
Pyridine | C5H5N – PubChem

Application of 66521-66-2, In the chemical reaction process,reaction time,type of solvent,can easily affect the result of the reaction, thereby determining the yield and properties of the reaction product.An updated downstream synthesis route of 66521-66-2 as follows.

General procedure: Reactions were carried out with 4-(pyridin-3-yl)pyrimidin-2-amine 1 (0.50 mmol), aldehyde 2 (0.50 mmol) and malonate 3 (5 mmol) in the presence of catalyst III or IV (10 molpercent) at 50 °C and stirred for 48h. After completion of the reaction (as observed by TLC), the crude product was purified by preparative TLC (GF254 silica gel: hexane/EtOAc = 7/1), giving the target chiral product

These compound has a wide range of applications. It is believed that with the continuous development of the source of the synthetic route,66521-66-2, its application will become more common.

Reference:
Article; Bai, Song; Liu, Shan; Zhu, Yunying; Lu, Jiali; Ai, Lina; Xue, Jing; Wu, Qin; Journal of Chemical Research; vol. 42; 8; (2018); p. 428 – 433;,
Pyridine – Wikipedia,
Pyridine | C5H5N – PubChem

Electric Literature of 1597-32-6, Researchers who often do experiments know that organic synthesis is a process of preparing more complex target molecules from simple raw materials through one or more chemical reactions. Generally, it requires fewer steps,and cheap raw materials. 1597-32-6, name is 2-Amino-6-fluoropyridine. A new synthetic method of this compound is introduced below.

To a solution of 4-cyanothiazole-2-carboxylic acid 15(30.0mg, 0.19 mmol) and N-methylmorpholine(60.0 muL, 0.53 mmol) in THF (5.0 mL) at -78C, isobutyl chloroformate (28.0 muL, 0.21 mmol) was added. The mixture was stirred at -5 C for 1 hour and a solution of2-amino-6-fluoropyridine (92.0 mg, 0.82 mmol) in THF (2.0 mL) was added. The mixture was stirred at room temperature overnight. The subsequent solution wasconcentrated under reduced pressure, extracted with H2O/ethylacetate and washed with HCl 1M. The combined organic layer was dried over Na2SO4, concentrated under reduced pressure and purified by column chromatography on silica gel using (hexane/ ethyl acetate = 3:1,) to afford N-(6-fluropyridin-2-yl)-4-cyanothiazole-2-carboxamide 6ce (20.0 mg, 41%) as pale yellow solid: 1H-NMR (400 MHz, CDCl3) delta 9.44 (s, 1H), 8.28 (s, 1H), 8.16-8.13 (dd, J = 7.80, J= 1.76, 1H), 7.91-7.85 (dd, J = 8.00, J = 16.0, 1H), 6.79-6.76 (dd, J= 8.00, J = 2.35, 1H). 13C-NMR(100 MHz, CDCl3) delta 164.5, 163.3, 160.9, 156.0,148.2, 148.1, 143. 6, 143.5, 135.8, 127.8, 112.8, 110.8, 110.77, 106.0, 105.7.LC/MS (ESI-) 246.9 (M-H)+.

At the same time, in my other blogs, there are other synthetic methods of this type of compound,1597-32-6, 2-Amino-6-fluoropyridine, and friends who are interested can also refer to it.

Reference:
Article; Vu, Hoang Nam; Kim, Ji Young; Hassan, Ahmed H.E.; Choi, Kihang; Park, Jong-Hyun; Park, Ki Duk; Lee, Jae Kyun; Pae, Ae Nim; Choo, Hyunah; Min, Sun-Joon; Cho, Yong Seo; Bioorganic and Medicinal Chemistry Letters; vol. 26; 1; (2016); p. 140 – 144;,
Pyridine – Wikipedia,
Pyridine | C5H5N – PubChem

Synthetic Route of 83004-13-1, The major producers of chemicals have been the Europe, Japan and China. Due to the growing call for a cleaner, greener environment, people will have to find innovative ways to maintain their relevance. Here is a compound 83004-13-1, name is 2-Bromo-6-ethylpyridine. This compound has unique chemical properties. The synthetic route is as follows.

b 2-Bromo-6-ethyl-pyridine 1-oxide To a solution of 2-bromo-6-ethyl-pyridine (15.4 g, 82.8 mmol) (S. G. Davies and M. R. Shipton, J. Chem. Soc., Perkin Trans. 1, 1991, 3, 501) in acetic acid (15 ml) was added peracetic acid (26 ml of a 39percent solution) maintaining T<50° C. After complete addition the mixture was stirred at 50° C. for 5 hr and then cooled to room temperature (rt). Crushed ice (40 g) was added and the pH was adjusted to pH 12 with 40percent aqueous KOH solution. After extraction with CHCl3 (6*60 ml) the combined organic phases were dried (Na2CO3) and evaporated to give 20.0 g (>100percent) of the title compound, MS: m/e=201 (M+) as a yellow oil.

According to the analysis of related databases, 83004-13-1, the application of this compound in the production field has become more and more popular.

Reference:
Patent; Alanine, Alexander; Buettelmann, Bernd; Heitz Neidhart, Marie-Paule; Pinard, Emmanuel; Wyler, Rene; US2003/119870; (2003); A1;,
Pyridine – Wikipedia,
Pyridine | C5H5N – PubChem