Tag: M.W:100-200

Researchers who often do experiments know that organic synthesis is a process of preparing more complex target molecules from simple raw materials through one or more chemical reactions. Generally, it requires fewer steps,and cheap raw materials. 581-45-3, name is 4-(Piperidin-4-yl)pyridine. A new synthetic method of this compound is introduced below., Product Details of 581-45-3

Following the procedure of Example 74 using 5,5-Dioxo-2-(4-nitrobenzoxy-carbonylamino)dibenzothiophene (Example 24) and the appropriate amine the following compounds were prepared.

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Reference:
Patent; Block, Michael Howard; Donald, Craig Samuel; Brittain, David Robert; Foote, Kevin Michael; US2003/225097; (2003); A1;,
Pyridine – Wikipedia,
Pyridine | C5H5N – PubChem

Reference of 74115-12-1 , The common heterocyclic compound, 74115-12-1, name is 5-Chloro-3-hydroxypyridine, molecular formula is C5H4ClNO, its traditional synthetic route has been very mature, but the traditional synthetic route has various shortcomings, such as complicated route, low yield, poor purity, etc., below Introduce a new synthetic route.

EXAMPLE 14; Preparation of 3-chloro-N-[(lS)-1-(4-chlorophenyl) ethyl]-5-(methoxymethoxy)-4-pyridine- carboxamide (Compound 179); Step A: Preparation of 3-chloro-5- (methoxymethoxy) pyridine; To a solution of 5-chloro-3-hydroxypyridine (Aldrich, 5 g, 39 mmol) in acetonitrile (60 mL) was added chloromethyl methyl ether (3.11 g, 39 mmol) followed by potassium carbonate (10.78 g). The mixture was heated at 60 C for 18 h and then diluted with water (100 mL). The aqueous layer was extracted with ethyl acetate (4 x 100 mL). The combined organic layers were dried (MgSO4), and the solvent was evaporated under reduced pressure to leave the title compound as a yellow oil (5.5 g). 1H NMR (CDC13) 8 3.49 (s, 3H), 5.30 (s, 2H), 7.42 (s, 1H), 8.26 (s, 1H), 8. 31 (s, 1H)

The synthetic route of 74115-12-1 has been constantly updated, and we look forward to future research findings.

Reference:
Patent; E.I. DUPONT DE NEMOURS AND COMPANY; WO2005/70889; (2005); A1;,
Pyridine – Wikipedia,
Pyridine | C5H5N – PubChem

Each compound has different characteristics, and only by selecting the characteristics of the compound suitable for a specific situation can the compound be applied on a large scale. 71902-33-5, name is 3,5-Difluoropyridine. This compound has unique chemical properties. The synthetic route is as follows. Recommanded Product: 71902-33-5

Into a 500 ml reaction flask, 400 ml of dichloromethane and 113.3 g of m-chloroperoxybenzoic acid were successively introduced.Water bath insulation drop between 25-30 °CA mixed solution of 57.5 g of 3,5-difluoropyridine and 100 ml of dichloromethane.Continue to stir at 25-30 ° C until the system becomes cloudy.After the reaction, 50 ml of 60percent potassium hydroxide aqueous solution was added, and the mixture was stirred for 0.5 hours, and then left to stand for liquid separation.Extract 300 times with 300 ml of dichloromethane. The organic phases were combined, dried over anhydrous sodium sulfate and concentrated to give 58.8 g of product.98..6percent.

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Reference:
Patent; Zhejiang Xingyue Pharmaceutical Technology Co., Ltd.; Tang Yang; Xu Zhigang; Ying Lv; Hu Junbin; Chen Qingquan; (5 pag.)CN109336810; (2019); A;,
Pyridine – Wikipedia,
Pyridine | C5H5N – PubChem

Each compound has different characteristics, and only by selecting the characteristics of the compound suitable for a specific situation can the compound be applied on a large scale. 58757-38-3, name is 6-Chloronicotinoyl chloride. This compound has unique chemical properties. The synthetic route is as follows. COA of Formula: C6H3Cl2NO

4-Aminoresorcinol HCI (620 mg, 2.8 mmol) was slurried in THF (10 ml) and triethylamine (1.6 ml, 3 eq) was added. To the stirred solution, cooled with an ice-bath, 6-chloronicotinoyl chloride (2.0 g, 3 eq) dissolved in THF (15 ml) was added dropwise. After the addition the mixture was allowed to stir for 3 days at rt. The reaction was poured out on ice and the solid was filtered. The wet solid was dissolved in THF (25 ml) and ethanol (25 ml) by heating. 2 M NaOH (20 ml) was added dropwise to the still warm solution. After 10 min the organic solvent was removed on the rotory evaporator and the mixture dissolved by adding more water. The solution was neutralized wit 6 M HCI (6 ml) and the solid was filtered to give 6-chloro-N-(2,4-dihydroxyphenyl)pyridine-3- carboxamide (0.71 g, 71% yield, m/z (M-l) 263.1).

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Reference:
Patent; KARIN & STEN MORTSTEDT CBD SOLUTIONS AB; SOHN, Daniel Dungan; (185 pag.)WO2019/197502; (2019); A1;,
Pyridine – Wikipedia,
Pyridine | C5H5N – PubChem

Application of 884495-36-7, The major producers of chemicals have been the Europe, Japan and China. Due to the growing call for a cleaner, greener environment, people will have to find innovative ways to maintain their relevance. Here is a compound 884495-36-7, name is 6-Chloro-2-methylnicotinaldehyde. This compound has unique chemical properties. The synthetic route is as follows.

A mixture of 6-chloro-2-methylpyridine-3-carboxaldehyde (1.87 g, 12.0 mmol), (4- hydroxy-phenylsulfanyl)-acetic acid tert-butyl ester (2.48 g, 10.7 mmol) and K2CO3 (0.830 g, EPO 6.00 mmol) in DMF (20 mL) was heated at 125 C for 1 h. The mixture was cooled to room temperature and DMF was removed. Aqueous work-up and purification by flash chromatography on basic Al2O3 gel (CH2Cl2/hexanes, 1 :1 in v/v) afforded [4-(5-formyl-6- methyl-pyridin-2-yloxy)-phenylsulfanyl]-acetic acid tert-butyi ester as a pale yellow solid (0.481 g, 13%). 1H NMR (CDCl3) delta 1.42 (s, 9H), 2.72 (s, 3H), 3.56 (s, 2H), 6.78 (d, IH, J= 8.4 Hz), 7.09-7.13 (m, 2H), 7.46-7.50 (m, 2H), 8.11 (d, IH, J= 8.4 Hz), 10.24 (s, IH).

According to the analysis of related databases, 884495-36-7, the application of this compound in the production field has become more and more popular.

Reference:
Patent; ANORMED INC.; WO2007/22371; (2007); A2;,
Pyridine – Wikipedia,
Pyridine | C5H5N – PubChem

Electric Literature of 939-23-1, The major producers of chemicals have been the Europe, Japan and China. Due to the growing call for a cleaner, greener environment, people will have to find innovative ways to maintain their relevance. Here is a compound 939-23-1, name is 4-Phenylpyridine. This compound has unique chemical properties. The synthetic route is as follows.

EXAMPLE 90 4-Phenylpyridine (15.5 g., 0.1 mole) dissolved in 185 ml. of absolute ethanol and 15 ml. of concentrated hydrochloric acid was reduced with hydrogen over 2 g. of platinum oxide under a hydrogen pressure of about 55 pounds p.s.i.g. The product was worked up in the manner described above in Example 72 and isolated in the form of the hydrochloride salt to give 15.3 g. of 4-cyclohexylpiperidine hydrochloride. (The free base gives m.p. 106-109 C.)

While traditionally a conservative industry, chemical producers will need to modernize their PR strategies to stay relevant.we look forward to future research findings about 939-23-1, 4-Phenylpyridine.

Reference:
Patent; Sterling Drug Inc.; US4160862; (1979); A;,
Pyridine – Wikipedia,
Pyridine | C5H5N – PubChem

Application of 56622-54-9, With the rapid development and complex challenges of chemical substances, the synthesis of new drugs is usually one of the most effective ways to increase yield.56622-54-9, name is (6-Methylpyridin-3-yl)methanamine, molecular formula is C7H10N2, molecular weight is 122.17, as common compound, the synthetic route is as follows.

[0557] To a solution of compound VII (0.5 g, 1.39 mmol, 1 eq) in DMF (50 mL) were added HATU (0.7 g, 1.8 mmol, 1.3 eq) and DIPEA (0.74 mL, 4.17 mmol, 3 eq) under argon atmosphere at 0 C. A DMF solution of C-(6-methyl-pyridin-3-yl)-methylamine (0.25 g, 2.09 mmol, 1.5 eq) was added and the resulting mixture was stirred at 23 C for 16 h. The mixture was diluted with ice water (40 mL) and the organic components were extracted with EtOAc (2 x 50 mL) and 10% MeOH/CH2C12 (50 mL), and the combined extracts were washed with brine (50 mL). The organic layer was dried over anhydrous sodium sulfate, filtered and concentrated under reduced pressure to provide the crude compound. The crude product was purified by flash Combiflash chromatography using 100-200 mesh silica gel eluting with 5% MeOH/CH2C12 to obtain compound (0.4 g, 62%) as an orange solid. 1H NMR (400 MHz, DMSO-d6) oe 9.53 (t, 1H, J = 6 Hz), 9.18 (s, 1H), 8.47 (s, 1H), 8.37 (s, 1H), 7.94 (s, 1H),7.70-7.44 (m, 2H), 7.23 (d, 1H, J = 8 Hz), 4.53 (d, 2H, J = 5 Hz), 2.45 (s, 3H). LCMS: m/z =463.0 [M+j, 465.0 [M+21, RT = 1.94 minutes; (Program Ri, Column W).

Statistics shows that 56622-54-9 is playing an increasingly important role. we look forward to future research findings about (6-Methylpyridin-3-yl)methanamine.

Reference:
Patent; ASANA BIOSCIENCES, LLC; THOMPSON, Scott; VENKATESAN, Aranapakam; PRIESTLEY, Tony; KUNDU, Mrinal; SAHA, Ashis; WO2015/95128; (2015); A1;,
Pyridine – Wikipedia,
Pyridine | C5H5N – PubChem

Each compound has different characteristics, and only by selecting the characteristics of the compound suitable for a specific situation can the compound be applied on a large scale. 58481-11-1, name is Methyl 2-chloroisonicotinate. This compound has unique chemical properties. The synthetic route is as follows. COA of Formula: C7H6ClNO2

Step 3 Preparation of 1-(2-Chloroisonicotinyl)-1,3-butanedione: To solution of methyl 2-chloroisonicotinate (12.0 g, 0.07 mol) and acetone (12.2 g, 0.21 mol) in 100 mL of dry THF at 35 C was added sodium methoxide portionwise. After heating the reaction mixture at reflux for 4 h, the solvent was removed. The residue was dissolved with 500 mL of water, acidified with acetic acid to pH=6 and extracted with ethyl acetate. The organic layer was washed with brine, dried over magnesium sulfate and filtered. The filtrate was concentrated in vacuo to give 11.46 g (83percent yield) of product was a brown solid.

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Reference:
Patent; Pharmacia Corporation; US6509361; (2003); B1;,
Pyridine – Wikipedia,
Pyridine | C5H5N – PubChem

Electric Literature of 6959-47-3, Adding some certain compound to certain chemical reactions, such as: 6959-47-3, name is 2-(Chloromethyl)pyridine hydrochloride,molecular formula is C6H7Cl2N, can increase the reaction rate and produce products with better performance than those obtained under traditional synthetic methods. Here is a downstream synthesis route of the compound 6959-47-3.

General procedure: L1 was prepared by a similar procedure as described in the literature [24,39-41]. A water solution (15.0mL) of cyclopentylamine (1.70g, 0.020mol) was added to a water solution (15.0mL) of 2-picolylchloride hydrochloride (6.58g, 0.040mol) and an added NaOH pellet (3.20g, 0.080mol). After 5days of stirring at rt, the product was extracted with dichloromethane. The reaction solution was dried over MgSO4, then the filtrate solvent was removed under reduced pressure to give a brown oil (4.01g, 75.0

According to the analysis of related databases, 6959-47-3, the application of this compound in the production field has become more and more popular.

Reference:
Article; Kim, Dongil; Kim, Sunghoon; Kim, Eunhee; Lee, Ha-Jin; Lee, Hyosun; Polyhedron; vol. 63; (2013); p. 139 – 146;,
Pyridine – Wikipedia,
Pyridine | C5H5N – PubChem

Related Products of 24484-93-3, As we all know, there are many different methods for the synthesis of a compound, and people can choose the synthesis method that suits their own laboratory according to the actual situation. 24484-93-3, name is Methyl 4-chloropicolinate, molecular formula is C7H6ClNO2, The compound is widely used in many fields, so it is necessary to find a new synthetic route. The downstream synthesis method of this compound is introduced below.

Preparation of 2-Chloromethyl-4-chloropyridine To a slurry of lithium aluminum hydride (0.45 g, 11.9 mmol) in anhydrous diethyl ether (40 mL) at 0 C., a solution of methyl 4-chloro-pyridine-2-carboxylate (2.0 g, 11.7 mmol) in diethyl ether (30 mL) was added. The resulting mixture was stirred at room temp. overnight, and quenched with successive addition of water (0.45 mL), 15% aqueous NaOH (0.45 mL), and water (1.35 mL). The resultant slurry was stirred at room temp. for 30 min., and filtered through a small plug of Celite. The filtrate was washed with brine, dried over anhydrous magnesium sulfate, filtered, and concentrated under vacuum to provide 4-chloro-2-hydroxymethylpyridine.

While traditionally a conservative industry, chemical producers will need to modernize their PR strategies to stay relevant.we look forward to future research findings about 24484-93-3, Methyl 4-chloropicolinate.

Reference:
Patent; Merck & Co., Inc.; US5891889; (1999); A;,
Pyridine – Wikipedia,
Pyridine | C5H5N – PubChem