Tag: M.W:100-200

Each compound has different characteristics, and only by selecting the characteristics of the compound suitable for a specific situation can the compound be applied on a large scale. 128071-98-7, name is 4-Bromo-2-fluoropyridine. This compound has unique chemical properties. The synthetic route is as follows. Application In Synthesis of 4-Bromo-2-fluoropyridine

Reaction under inert Ar atmosphere.Intermediate (136) (1 g, 0.00306 mol) was dissolved in TFA (15 ml). The solution was stirred overnight at 1000C. The mixture was cooled and the deep black mixture was concentrated in vacuo. The residue was taken up in ethyl acetate. The organic layer was washed with NaHCO3 (saturated), water and brine, dried (Na2SO4), filtered and the solvent was evaporated (green residue). This green solid was dissolved in dioxane (15 ml) under an inert atmosphere of Ar. 4-Bromo-2-fluoropyridine (0.00306 mol), Cs2CO3 (1.5 g, 1.5 equiv.), Xantphos (0.09 g) and Pd2(dba)3 (0.08 g) were added. The reaction was degassed for 15 minutes and was then heated for 30 minutes at 800C. The cooled mixture was concentrated in vacuo and the resulting thick brown oil was taken up in chloroform. The organic layer was washed with NaHCO3 (saturated), water and brine, dried (Na2SO4), filtered and the solvent was evaporated to yield a brown solid. This solid was purified by column chromatography over silica gel (eluent: hexane/ethyl acetate 1/1). The desired fractions were collected and the solvent was evaporated, yielding 0.642 g of intermediate (137).

If you are interested in these compounds, you can also browse my other articles.Thank you for taking the time to read this article. I hope you enjoyed it, 128071-98-7, 4-Bromo-2-fluoropyridine.

Reference:
Patent; JANSSEN PHARMACEUTICA NV; WO2008/3665; (2008); A1;,
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Each compound has different characteristics, and only by selecting the characteristics of the compound suitable for a specific situation can the compound be applied on a large scale. 7418-65-7, name is 4-Aminonicotinic acid. This compound has unique chemical properties. The synthetic route is as follows. Product Details of 7418-65-7

[00323] Compound A9 (3 g, 21.72 mmol) in MeOH (50 mL) was cooled to 0 C and H2S04 was added dropwise, after the addition, the mixture was stirred at 0 C for 30 mm, then the mixture was heated to 80 C overnight. TLC showed the reaction was completed, the mixture was acidized to pH 8 with NaHCO3, then the solution was extracted with EA three times, the organic layer was washed with water and brine, dried over Na2SO4, evaporated to get the product A9-1 (3 g, purity : 90% on TLC) without further purification. ?H NMR (400 M, DMSO) 8.66 (s, 2 H), 8.07 (d, J= 6Hz, 1H), 7.27 (s, 2 H), 6.68 (d, J= 5.6 Hz, 1H), 3.81 (s, 3H) ppm.

If you are interested in these compounds, you can also browse my other articles.Thank you for taking the time to read this article. I hope you enjoyed it, 7418-65-7, 4-Aminonicotinic acid.

Reference:
Patent; DANA-FARBER CANCER INSTITUTE, INC.; WHITEHEAD INSTITUTE FOR BIOMEDICAL RESEARCH; BRADNER, James, E.; MCKEOWN, Michael, R.; RAHL, Peter, B.; YOUNG, Richard, A.; MARINEAU, Jason, J.; WO2014/71247; (2014); A1;,
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Each compound has different characteristics, and only by selecting the characteristics of the compound suitable for a specific situation can the compound be applied on a large scale. 55338-73-3, name is 5-Amino-2-pyridinecarbonitrile. This compound has unique chemical properties. The synthetic route is as follows. HPLC of Formula: C6H5N3

A 18 ml vial was loaded with a mixture of 30% H2O2 (1 ml), 3N NaOH (3 ml) and MeOH (2.5 ml). To this mixture 5-Amino-pyridine-2-carbonitrile (450 mg, 3.78 mmole) was added at room temperature. Reaction mixture was stirred at rt for 45 minutes, TLC showed the starting material to be consumed. The mixture was diluted with water and filtered; the solid was washed with water and dried to give 480 mg product, 92% yield.

If you are interested in these compounds, you can also browse my other articles.Thank you for taking the time to read this article. I hope you enjoyed it, 55338-73-3, 5-Amino-2-pyridinecarbonitrile.

Reference:
Patent; Nivalis Therapeutics, Inc.; Wasley, Jan; Rosenthal, Gary J.; Sun, Xicheng; Strong, Sarah; Qiu, Jian; US9138427; (2015); B2;,
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Pyridine | C5H5N – PubChem

Application of 70298-88-3, As we all know, there are many different methods for the synthesis of a compound, and people can choose the synthesis method that suits their own laboratory according to the actual situation. 70298-88-3, name is 2,2-Dimehtyl-N-pyridin-3-yl-propionamide, molecular formula is C10H14N2O, The compound is widely used in many fields, so it is necessary to find a new synthetic route. The downstream synthesis method of this compound is introduced below.

nBuLi (2.5M in hexanes, 56.2 ml_, 140.5 mmol) was dropwise added to a solution of the title compound of Preparation 1a (10 g, 56.2 mmol) and N,N,N’,N’-tetramethylethylene- diamine (TMEDA) (20.9 ml_, 140.5 mmol) in diethyl ether (338 ml.) at -78 0C under argon and the resulting mixture was stirred at that temperature for 15 minutes and at -10 0C for 2 hours. Then, the reaction mixture was cooled down to -780C and 2-methoxybenzaldehyde (19.52 g, 140.5 mmol) in 34 ml_ of dry tetrahydrofuran was carefully added. After 15 minutes, the cooling bath was removed and the mixture stirred overnight at room temperature. Subsequently, water (100 mL) was added to the flask and it was extracted with ethyl acetate (3 x 200 mL), the organic solution was washed with brine, dried over sodium sulphate and the solvent removed under reduced pressure. The residue was purified by column chromatography on silica flash, using hexane/ethyl acetate (4:1 ) as eluents, to yield the title compound (11.1 g, 63%) as a solid.

While traditionally a conservative industry, chemical producers will need to modernize their PR strategies to stay relevant.we look forward to future research findings about 70298-88-3, 2,2-Dimehtyl-N-pyridin-3-yl-propionamide.

Reference:
Patent; LABORATORIOS ALMIRALL, S.A.; WO2007/96072; (2007); A2;,
Pyridine – Wikipedia,
Pyridine | C5H5N – PubChem

Electric Literature of 1073182-59-8 , The common heterocyclic compound, 1073182-59-8, name is Methyl 5-amino-2-chloroisonicotinate, molecular formula is C7H7ClN2O2, its traditional synthetic route has been very mature, but the traditional synthetic route has various shortcomings, such as complicated route, low yield, poor purity, etc., below Introduce a new synthetic route.

[00481] To a stirred solution of (5-amino-2-chloro-isonicotinic acid methyl ester (1.3 g, 7 mmol) in DCM (30 mL) was added Et3N (1.4 g, 14 mmol) and cyclopropanecarbonyl chloride (1.1 g, 10.5 mmol) at 0 C. The mixture was stirred at room temperature overnight. The mixture was evaporated in vacuum. The residue was diluted with water (50 mL). The aqueous phase was extracted with EA (80 mL x2). The extracts were washed with water, dried over anhydrous Na2S04 and filtered. The filtrate was evaporated in vacuum to residue, which was purified by silica gel chromatography (from PE to PE/EA = 10/1) to give (1.0 g, yield: 56 %) of 2-chloro-5-(cyclopropanecarbonyl-amino)-isonicotinic acid methyl ester as yellow solid. ‘H NMR (400MHZ, DMSO-i/6): delta = 10.56 (brs, 1H), 8.79 (s, 1H), 7.23 (s, 1H), 3.82 (s, 3H), 1.87- 1.80 (m, 3H), 0.94-0.83 (m, 4H).

The synthetic route of 1073182-59-8 has been constantly updated, and we look forward to future research findings.

Reference:
Patent; HEDRICK Michael P.; HERSHBERGER Paul M.; MALONEY Patrick R.; PEDDIBHOTLA Satyamaheshwar; PINKERTON Anthony B.; WO2015/200534; A2; (2015);,
Pyridine – Wikipedia,
Pyridine | C5H5N – PubChem

In the next few decades, the world population will flourish. As the population grows rapidly and people all over the world use more and more resources, all industries must consider their environmental impact. 17874-79-2, name is 5-(Methoxycarbonyl)picolinic acid, the common compound, a new synthetic route is introduced below. Product Details of 17874-79-2

A solution of 5-(methoxycarbonyl)picolinic acid (3.33 g, 18.4 mmol) in a mixture of pyridine (20 mL) and N,N-dimethylformamide (35 mL) was treated with 1,1′-carbonyldiimidazole (3.28 g, 20.2 mmol) at 45 C. for 2 hours. After cooling, 2,3-diaminobenzamide (HCl salt) (4.12 g, 18.4 mmol) was added and the mixture stirred at room temperature overnight. The mixture was concentrated and the residue used in the next step without further purification.

The synthetic route of 17874-79-2 has been constantly updated, and we look forward to future research findings.

Reference:
Patent; ABBOTT LABORATORIES; US2009/30016; (2009); A1;,
Pyridine – Wikipedia,
Pyridine | C5H5N – PubChem

Adding a certain compound to certain chemical reactions, such as: 18364-47-1, N-Methylpyridin-3-amine, can increase the reaction rate and produce products with better performance than those obtained under traditional synthetic methods. Here is a downstream synthesis route of the compound, 18364-47-1, blongs to pyridine-derivatives compound. category: pyridine-derivatives

A mixture of 5.65 g (35.1 mmol) (IV-1), 75 mol of anhydrous pyridine and 4.19 g (38.7 mmol) of 3-methylaminopyridine was heated to reflux under argon for 8 hours, freed of the solvent under reduced pressure and the residue was stirred with 100 ml of ethanol and 0.1 mol of potassium carbonate at room temperature for one hour, the solid filtered off and the filtrate evaporated to dryness. The product was obtained from the residue by chromatography on silica gel using a mixture of dichloromethane and methanol. 1H-NMR (DMSO-d6, 600 MHz); delta=3.24 (s, 3H), 3.31 (s, 3H), 5.83 (s, 1H), 7.43-7-45 (m, 1H), 7.80-7.82 (m, 1H), 8.47-8.48 (m, 1H), 8.52 (m, 1H), 10.38 (s, 1H) ppm.1H-NMR (CD3CN, 400 MHz); delta=3.30 (s, 3H), 3.35 (s, 3H), 5.69 (s, 1H), 7.35-7-39 (m, 1H), 7.65-7.68 (m, 1H), 8.45-8.48 (m, 2H), 8.73 (br. s, 1H) ppm.

These compound has a wide range of applications. It is believed that with the continuous development of the source of the synthetic route,18364-47-1, its application will become more common.

Reference:
Patent; Bayer CropScience Aktiengesellschaft; JANSEN, Johannes-Rudolf; HEIL, Markus; FISCHER, Reiner; WILCKE, David; WILLOT, Matthieu; ILG, Kerstin; EILMUS, Sascha; LOeSEL, Peter; ANDERSCH, Wolfram; (67 pag.)US2019/40042; (2019); A1;,
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Application of 133081-24-0 ,Some common heterocyclic compound, 133081-24-0, molecular formula is C6H7N3O2, its traditional synthetic route has been very mature, but the traditional synthetic route has various shortcomings, such as complicated route, low yield, poor purity, etc., below Introduce a new synthetic route.

6-chloronicotinic acid (1.6 g ) in MeOH (1OmL) was treated with NH2NH2 (2 g) at 140 0C for 2h. After cooling to -20 0C, the solid was filtered to give 560mg of compound 33B. Compound 33B was treated with isothiocyanatobenzene (141 mg) in 1 ,2-dichlorobenzene (5 mL) at 100 0C for 10 min, and then 180 0C for Ih. The product was purified by LCMS to give 3-mercapto- [l,2,4]triazolo[4,3-a]pyridine-6-carboxylic acid (450mg). ESI-MS:m/z 196.1 (M+H)+.

In the field of chemistry, the synthetic routes of compounds are constantly being developed and updated. I will also mention this compound in other articles. 133081-24-0, 6-Hydrazinylnicotinic acid, other downstream synthetic routes, hurry up and to see.

Reference:
Patent; TAKEDA PHARMACEUTICAL COMPANY LIMITED; BRESSI, Jerome, C.; CHU, Shaosong; ERICKSON, Philip; KOMANDLA, Mallareddy; KWOK, Lily; LAWSON, John, D.; STAFFORD, Jeffrey, A.; WALLACE, Michael, B.; ZHANG, Zhiyuan; DAS, Sanjib; WO2010/19899; (2010); A1;,
Pyridine – Wikipedia,
Pyridine | C5H5N – PubChem

Application of 132308-19-1, The major producers of chemicals have been the Europe, Japan and China. Due to the growing call for a cleaner, greener environment, people will have to find innovative ways to maintain their relevance. Here is a compound 132308-19-1, name is Methyl 5-chloropyridine-2-carboxylate. This compound has unique chemical properties. The synthetic route is as follows.

To the reaction flask was added 1 mmol of compound F5,N, N-dimethylglycine,Copper iodide,Cs2CO3,1,4-dioxane and2 mmol of methyl 5-chloropyridine-2-carboxylate,Nitrogen under the protection of heating to 80 C reaction 24h,After the reaction was complete,Extracted with ethyl acetate,The organic phases were combined and dried over anhydrous sodium sulfate; after concentration under pressure,And then purified on a silica gel column (eluent petroleum ether: ethyl acetate = 1: 1)To give the object product as a pale yellow oily liquid.

While traditionally a conservative industry, chemical producers will need to modernize their PR strategies to stay relevant.we look forward to future research findings about 132308-19-1, Methyl 5-chloropyridine-2-carboxylate.

Reference:
Patent; Guangdong Zhongsheng Pharmaceutical Co., Ltd.; Chen, Lijuan; Long, Chaofeng; Chen, Xiaoxin; Liu, Zhuowei; Ye, Haoyu; Xie, Chengshi; (104 pag.)CN106045923; (2016); A;,
Pyridine – Wikipedia,
Pyridine | C5H5N – PubChem

Related Products of 5969-83-5, The major producers of chemicals have been the Europe, Japan and China. Due to the growing call for a cleaner, greener environment, people will have to find innovative ways to maintain their relevance. Here is a compound 5969-83-5, name is 2-(4-Chlorophenyl)pyridine. This compound has unique chemical properties. The synthetic route is as follows.

General procedure: In a typical reaction, a 10 mL oven-dried reaction vessel was charged with Pd/MgLa mixed oxide (30 mg), 2-phenylpyridine (29 mg, 0.2 mmol), benzyl alcohol (108 mg, 1 mmol), tert-butyl hydroperoxide (70% solution in water, ?129 mg, 1 mmol) and chlorobenzene (0.5 mL) were added. The resulting solution was stirred at 120 C for 8 h in open air. The reaction was monitored by thin-layer chromatography (TLC). After cooling to room temperature, catalyst was separated by simple centrifugation. The filtrate was concentrated under reduced pressure and the residue was purified by column chromatography using silica gel and a mixture of hexane/ethyl acetate as eluents. All the products were confirmed by 1H NMR and 13C NMR spectroscopy. The recovered catalyst was used for the next cycle without any further purification.

According to the analysis of related databases, 5969-83-5, the application of this compound in the production field has become more and more popular.

Reference:
Article; Kishore; Kantam, M. Lakshmi; Yadav; Sudhakar; Laha; Venugopal; Journal of Molecular Catalysis A: Chemical; vol. 379; (2013); p. 213 – 218;,
Pyridine – Wikipedia,
Pyridine | C5H5N – PubChem