Tag: M.W:100-200

Adding a certain compound to certain chemical reactions, such as: 1539-42-0, Bis(pyridin-2-ylmethyl)amine, can increase the reaction rate and produce products with better performance than those obtained under traditional synthetic methods. Here is a downstream synthesis route of the compound, Product Details of 1539-42-0, blongs to pyridine-derivatives compound. Product Details of 1539-42-0

N-(2-pyridylmethyl)amine 0.5 mL, N-(2-bromoethyl)phthalimide 0.75g it was heated to 5 mL at 95 C with 0.5 g of potassium carbonate. After cooling to room temperature, the reaction mixture was poured into ice water for 2 hr. The crude product was filtered off and washed with cold water and dried with calcium chloride under vacuum. A yellow brown solid 680 mg was obtained in a yield of 65.7%.

The synthetic route of 1539-42-0 has been constantly updated, and we look forward to future research findings.

Reference:
Patent; Shenzhen University; Lin Jing; Ma Gongcheng; Zeng Leli; Huang Peng; (24 pag.)CN109020955; (2018); A;,
Pyridine – Wikipedia,
Pyridine | C5H5N – PubChem

With the rapid development and complex challenges of chemical substances, the synthesis of new drugs is usually one of the most effective ways to increase yield.73781-91-6, name is Methyl 6-chloronicotinate, molecular formula is C7H6ClNO2, molecular weight is 171.58, as common compound, the synthetic route is as follows.COA of Formula: C7H6ClNO2

Example 7. Preparation of 0-(6-pyrazol-l-yl-pyridin-3-almethel)-hadroxylamine (Compound of formula (Xl)); Step 7a. Preparation of 6-Pyrazol-1-vl-nicotinic acid methyl ester (Compound of formula (XI-a)); To a solution of pyrazole (19.4g, 0. 28mol) in 100 mL anhydrous DMSO, which was at a temperature of 0C, was added NaH (7. 5g, 0. 3mol) gradually over a period of 30 min. The resulting reaction mixture was allowed to warm to room temperature, at which the mixture continued to agitate for an additional 30 min. Methyl 6- chloronicotinate (35g, 0. 2mol) was added to the stirring reaction mixture and agitated vigorously for a period of 6 hr. The reaction mixture was subsequently cooled to a temperature of about 0C and poured into a saturated aqueous, 0C NH4C1 solution. The resulting precipitate was filtered, washed with water, and dried to give a compound of formula (XI-a) (38.3g, 93% yield) as an off-white solid.

At the same time, in my other blogs, there are other synthetic methods of this type of compound,73781-91-6, Methyl 6-chloronicotinate, and friends who are interested can also refer to it.

Reference:
Patent; ENANTA PHARMACEUTICALS, INC.; WO2005/70918; (2005); A1;,
Pyridine – Wikipedia,
Pyridine | C5H5N – PubChem

Related Products of 94166-64-0, In the chemical reaction process,reaction time,type of solvent,can easily affect the result of the reaction, thereby determining the yield and properties of the reaction product.An updated downstream synthesis route of 94166-64-0 as follows.

In a 20 ml microwave vial, 2-chloro-6-nitropyridine (1.0 g, 6.3 mmol) was dissolved in dioxane (10 ml) and piperidine-4-carboxamide (1.05 g, 1.3 eq) was added followed by Hunig’s base (3.3 ml, 3 eq). The reaction was subjected to in the microwave for 2.5 h at 180 C. The reaction mixture was diluted with water, the mixture was extracted twice with hot ethyl acetate, treated with brine, dried with MgS04, filtered and the solvent was removed in vacuo to give the crude product. The crude product was refluxed with DCM (10 ml), the solution was allowed to cool and washed with DCM to give the purified crude product as a solid. The solid was recrystallized from 2% hexane/ ethyl acetate to give [l-(6-nitropyridin-2-yl)piperidine-4-carboxamide (0.53 g solid, 33% yield, HPLC Rf 2.18 min, MS m/z (M+l) 251.3, (M-l) 249.2). TLC ethyl acetate Rf 0.26.

These compound has a wide range of applications. It is believed that with the continuous development of the source of the synthetic route,94166-64-0, its application will become more common.

Reference:
Patent; KARIN & STEN MORTSTEDT CBD SOLUTIONS AB; SOHN, Daniel Dungan; (185 pag.)WO2019/197502; (2019); A1;,
Pyridine – Wikipedia,
Pyridine | C5H5N – PubChem

Electric Literature of 6302-02-9, In the chemical reaction process,reaction time,type of solvent,can easily affect the result of the reaction, thereby determining the yield and properties of the reaction product.An updated downstream synthesis route of 6302-02-9 as follows.

EXAMPLE 19 2-Guanidino-4-methyl-5-(2-pyridyl)thiazole (0.16 g) was obtained according to substantially the same manner as that of Example 17 from 1-(2-pyridyl)acetone (2.8 g) and N-amidinothiourea (1.18 g). mp 166-168 C. IR (Nujol): 3440, 3400, 3270, 3080, 1630, 1600, 1580, 1540, 1520, 1420, 1320, 1240 cm-1 NMP (DMSO-d6, delta): 2.42 (3H, s), 6.8-7.1 (1H, m), 7.36 (1H, d, J=7 Hz), 7.5-7.8 (1H, m), 8.33 (1H, d d., J=2 Hz, 7 Hz) Mass. 233 (M+)

These compound has a wide range of applications. It is believed that with the continuous development of the source of the synthetic route,6302-02-9, its application will become more common.

Reference:
Patent; Fujisawa Pharmaceutical Co., Ltd.; US4649146; (1987); A;,
Pyridine – Wikipedia,
Pyridine | C5H5N – PubChem

Application of 934-37-2 ,Some common heterocyclic compound, 934-37-2, molecular formula is C8H8N2, its traditional synthetic route has been very mature, but the traditional synthetic route has various shortcomings, such as complicated route, low yield, poor purity, etc., below Introduce a new synthetic route.

2-methylimidazo[1,2-a]pyridine-3-carbaldehyde: Over excess of anhydrous DMF at 0 C are added slowly 2.5 equivalents of POCl3 and the mixture is mixed during 15 min. Posterior, one equivalent of compound 2-methylimidazo[1,2-a]pyridine is added and the reaction mixture is stirred vigorously by 1 h. Then the reaction is warmed at 60 C. Chopped ice was added and the mixture is neutralized with ammonium hydroxide. Oil was obtained which was solubilized in hot hexane, after cooling a solid was formed. Recrystallized from hexane to obtain a white solid. Yield 59 %; m.p. 118-119 C. 1H NMR (300 MHz, CDCl3) ppm 2.73 (s, 3 H), 7.07 (dd, J = 1.2 Hz, 6.8 Hz, 1 H), 7.52 (ddd, J = 1.2 Hz, 6.8 Hz, 9.0 Hz, 1 H), 7.68 (dd, J = 1.2 Hz, 9.0 Hz, 1 H), 10.01 (s, 1 H). 13C NMR (75 MHz, CDCl3) ppm 114.5, 114.8, 116.6, 121.2, 128.3, 130.0, 147.7, 157.1, 177.0. MS (EI, 70 eV): m/z [%] = 160[M]+ (100), 159[M-H]+ (98), 131[M-CHO]+ (25).

These compound has a wide range of applications. It is believed that with the continuous development of the source of the synthetic route,934-37-2, its application will become more common.

Reference:
Article; Garcia-Carrillo, Mario Alfredo; Guzman, Angel; Diaz, Eduardo; Tetrahedron Letters; vol. 58; 20; (2017); p. 1952 – 1956;,
Pyridine – Wikipedia,
Pyridine | C5H5N – PubChem

Adding a certain compound to certain chemical reactions, such as: 93-60-7, Methyl nicotinate, can increase the reaction rate and produce products with better performance than those obtained under traditional synthetic methods. Here is a downstream synthesis route of the compound, Computed Properties of C7H7NO2, blongs to pyridine-derivatives compound. Computed Properties of C7H7NO2

To a stined solution of methyl nicotinate (500gm) in isopropyl alcohol was addedhydrazine hydrate (80%) (460m1). Resultant mixture was heated and stined at 80-85C for 4hrs. Reaction mixture was cooled to RT. Separated solid was filtered, washed with isopropyl alcohol and dried to give title compound as off white solid.?H NMR (DMSO-d6, 400 MHz, ppm): 9.967(1H, singlet), 8.967-8.961(1H, singlet), 8.699- 8.683(1H, doublet), 8.167-8.138(1H, doublet), 7.512-7.479(1H, triplet), 4.567(2H, Singlet) Mass (mlz):138 (M + 1)

The synthetic route of 93-60-7 has been constantly updated, and we look forward to future research findings.

Reference:
Patent; TORRENT PHARMACEUTICALS LIMITED; DUTT, Chaitanya; GUPTA, Rameshchandra; PATEL, Manish; ABRAHAM, Jaya; MISHRA, Vivek; KESARWANI, Amit; DESHPANDE, Shailesh; ZAMBAD, Shital, Kumar; MATHUR, Anoop; KOTECHA, Jignesh; LATAD, Sachin; CHAUDHARI, Anita; (45 pag.)WO2016/162785; (2016); A1;,
Pyridine – Wikipedia,
Pyridine | C5H5N – PubChem

In the next few decades, the world population will flourish. As the population grows rapidly and people all over the world use more and more resources, all industries must consider their environmental impact. 1594-58-7, name is N-Hydroxynicotinimidamide, the common compound, a new synthetic route is introduced below. Safety of N-Hydroxynicotinimidamide

To a solution of 5-(lH-pyrrol-l-yl)nicotinic acid (Maybridge, 188 mg, 1.00 mmol) in dimethylformamide (anhydrous, 5 mL) was added N-(3-methylaminopropyl)-N’- ethylcarbodiimide hydrochloride (EDC) (Aldrich, 192 mg, 1.00 mmol) and 1- hydroxybenzotriazole (HOBT) hydrate (Fluka, 153 mg, 1.00 mmol). The mixture was stirred at ambient temperature for 20 minutes. lambdaf’-Hydroxynicotinimidamide (137 mg, 1.0 mmol) was added and the mixture was stirred for 6-10 hours, and then warmed to 140 0C for 2-4 hours. The reaction was cooled to ambient temperature and triturated with water (10 mL). The precipitate was filtered and dried under vacuum to give the titled compound. 1H NMR (300 MHz, DMSO-J6) delta 6.34 – 6.44 (m, 2 H), 7.60 – 7.82 (m, 3 H), 8.50 (dt, J=8.1, 1.9 Hz, 1 H), 8.71 (dd, J=2.5, 1.9 Hz, 1 H), 8.84 (dd, J=4.6, 1.5 Hz, 1 H), 9.21 (d, J=1.7 Hz, 1 H), 9.26 (d, J=2.4 Hz, 1 H), 9.31 (d, J=I .7 Hz, 1 H) ppm; MS (DCI/NH3) m/z 290 (M+H)+.

The synthetic route of 1594-58-7 has been constantly updated, and we look forward to future research findings.

Reference:
Patent; ABBOTT LABORATORIES; WO2009/148452; (2009); A1;,
Pyridine – Wikipedia,
Pyridine | C5H5N – PubChem

Synthetic Route of 73027-79-9, In the chemical reaction process,reaction time,type of solvent,can easily affect the result of the reaction, thereby determining the yield and properties of the reaction product.An updated downstream synthesis route of 73027-79-9 as follows.

Oxalic dichloride (2.8 g, 22.1 mmol) was added dropwise to a pre-cooled mixture at 0 C of 4,6- dichloronicotinic acid (1.40 g, 7.29 mmol) and NN-dimethylformamide (0.10 mL, 1.29 mmol) in dichloromethane (20 mL). The resulting mixture was stirred for 3 h at room temperature. After the reaction was completed, the resulting mixture was concentrated in vacuo to afford the title compound (1.8 g ) as a yellow solid, which was carried forward without purification.

These compound has a wide range of applications. It is believed that with the continuous development of the source of the synthetic route,73027-79-9, its application will become more common.

Reference:
Patent; GENENTECH, INC.; BRYAN, Marian C.; CHAN, Bryan; DIEDERICH, Francois; DOTSON, Jennafer; HANAN, Emily; HEFFRON, Timothy; LAINCHBURY, Michael; HEALD, Robert; SEWARD, Eileen M.; WO2014/210354; (2014); A1;,
Pyridine – Wikipedia,
Pyridine | C5H5N – PubChem

Reference of 13466-43-8, As we all know, there are many different methods for the synthesis of a compound, and people can choose the synthesis method that suits their own laboratory according to the actual situation. 13466-43-8, name is 3-Bromopyridin-2(1H)-one, molecular formula is C5H4BrNO, The compound is widely used in many fields, so it is necessary to find a new synthetic route. The downstream synthesis method of this compound is introduced below.

In a sealed tube, a suspension of 400 mg (1.09 mmol) of tert-butylN-[1-[(4-acetylenyl-6- isoquinolyl)methyl] -4-piperidyl]carbamate, 240 mg( 1.38 mmol) of 3 -bromo-2-hydroxypyridine, 77 mg(0.1 1 mmol) of Pd(PPh3)2C12 and 535 mg (1.64 mmol) of Cs2CO3 in 10 mL of DMF under an inert atmo sphere was stirred at 110C for 16 h. The mixture was extracted with EA/H20. The organic layerwashed with brine, dried over anhydrous Na2SO4, and concentrated in vacuo to give the crude product,which was purified via silica gel (pure EA) to give 107 mg of product as a light yellow semisolid.MS (+ESI): 459.3 [M+H].?H NMR (400 MHz, DMSO-d6+D20) ppm: 9.35 (s, 1H), 8.88 (s, 1H), 8.36 (d, J = 4.8 Hz, 1H), 8.30 (s, 1H), 8.22-8.20 (m, 2H), 7.65 (d, J = 8.0 Hz, 1H), 7.56 (s, 1H), 7.44 (m, 1H), 3.66 (s, 2H), 3.19 (m, 1H),2.73 (m, 2H), 2.05 (m, 2H), 1.66 (m, 2H), 1.37 (m, 2H), 1.32 (s, 9H).

While traditionally a conservative industry, chemical producers will need to modernize their PR strategies to stay relevant.we look forward to future research findings about 13466-43-8, 3-Bromopyridin-2(1H)-one.

Reference:
Patent; BASILEA PHARMACEUTICA AG; POHLMANN, Jens; STIEGER, Martin; REINELT, Stefan; LANE, Heidi; (286 pag.)WO2016/128465; (2016); A1;,
Pyridine – Wikipedia,
Pyridine | C5H5N – PubChem

Adding a certain compound to certain chemical reactions, such as: 131747-61-0, (2-(Trifluoromethyl)pyridin-4-yl)methanol, can increase the reaction rate and produce products with better performance than those obtained under traditional synthetic methods. Here is a downstream synthesis route of the compound, 131747-61-0, blongs to pyridine-derivatives compound. Recommanded Product: (2-(Trifluoromethyl)pyridin-4-yl)methanol

534 tert-Butyl N-[(3-hydroxyphenyl)methyl]carbamate (0.18 g, 1.0 mmol), E-1 (0.22 g, 1.0 mmol) and 13 triphenylphosphine (0.39 g, 1.5 mmol) were dissolved in 12 dichloromethane (3 mL), 236diisopropyl azodicarboxylate (0.32 mL, 1.5 mmol) was added, and the mixture was stirred at roomtemperature for 1 hr. The reaction mixture was concentrated under reduced pressure and the obtained residuewas purified by silica gel column chromatography (hexane/ethyl acetate). To the obtained compound wasadded 4 mol/L 114 hydrochloric acid (1,4-dioxane solution, 3 mL), and the mixture was stirred at roomtemperature for 1 hr, and concentrated under reduced pressure to give the 535 title compound ( 0.13 g ,0.40 mmol, 40%) MS (ESI) m/z 283 (M+H)+

These compound has a wide range of applications. It is believed that with the continuous development of the source of the synthetic route,131747-61-0, its application will become more common.

Reference:
Patent; EA PHARMA CO., LTD.; KOBAYASHI, Kaori; SUZUKI, Tamotsu; KAWAHIRA, Mizuki; FUJII, Tomohiro; SUGIKI, Masayuki; OHSUMI, Koji; OKUZUMI, Tatsuya; (285 pag.)US2016/332999; (2016); A1;,
Pyridine – Wikipedia,
Pyridine | C5H5N – PubChem