Tag: M.W:100-200

Electric Literature of 139585-70-9 ,Some common heterocyclic compound, 139585-70-9, molecular formula is C6H3BrN2, its traditional synthetic route has been very mature, but the traditional synthetic route has various shortcomings, such as complicated route, low yield, poor purity, etc., below Introduce a new synthetic route.

10 mmol, 1.58 g), Na2CO3 (0.5 mmol, 57 mg), 2-bromo-5-cyanopyridine(0.1 mmol, 115 mg) was dissolved in a mixed solvent of toluene / ethanol / water (V: V = 5: 2: 1). After 24 hours of refluxing, the reaction was stopped and the reaction mixture was left to stand at room temperature , Washed with dichloromethane, and then the organic phase was collected and purified by silica gel column chromatography to obtain 2.1 g of 2- (2 ‘, 4’-difluorophenyl) -5-amidopyridine as a white solid (yield : 89%);

These compound has a wide range of applications. It is believed that with the continuous development of the source of the synthetic route,139585-70-9, its application will become more common.

Reference:
Patent; UNIVERSITY OF SCIENCE AND TECHNOLOGY OF SUZHOU; ZHOU, YUYANG; WANG, XIAOMEI; YE, CHANGQING; ZHU, SAIJIANG; LIANG, ZUOQIN; (6 pag.)CN104016914; (2016); B;,
Pyridine – Wikipedia,
Pyridine | C5H5N – PubChem

Synthetic Route of 1195-59-1, Adding some certain compound to certain chemical reactions, such as: 1195-59-1, name is 2,6-Pyridinedimethanol,molecular formula is C7H9NO2, can increase the reaction rate and produce products with better performance than those obtained under traditional synthetic methods. Here is a downstream synthesis route of the compound 1195-59-1.

A solution of (b) (1.39 g, 10 mmol) in 35 mL of CH2Cl2 was added to a 40% aqueous solution of KOH (35 mL). The reaction mixture was cooled at 0 C and stirred for 30 min, after which a solution of p-toluenesulfonyl chloride (3.81 g, 20 mmol) was added in one portion. The reaction mixture was stirred for 1 h at 0 C and then at room temperature until complete conversion (TLC, 1/4 methanol/toluene). The reaction mixture was added to water (35 mL). The aqueous phase was extracted with CH2Cl2 (3 * 20 mL), the combined organic phase was dried over anhydrous MgSO4, filtered, and the solvent was removed under reduced pressure to afford a white crystalline solid (3.89 g, 87%) with Mp 119-121 C (121-122 C in [28] ). FT-IR (solid, cm-1): 3070, 3038 nu (C-H), 1596 nu (Cfx1C), 743 delta (C-H). 1H NMR (CDCl3), deltaH ppm: 2.46 (s, 6H, CH3), 5.08 (s, 4H, CH2), 7.34-7.83 (m, 11H).

In the field of chemistry, the synthetic routes of compounds are constantly being developed and updated. I will also mention this compound in other articles. 1195-59-1, 2,6-Pyridinedimethanol, other downstream synthetic routes, hurry up and to see.

Reference:
Article; Aghatabay, Naz Mohammed; Altun, Ahmet; Guerbuez, Mustafa Ulvi; Tuerkyilmaz, Murat; Comptes Rendus Chimie; vol. 17; 9; (2014); p. 905 – 912;,
Pyridine – Wikipedia,
Pyridine | C5H5N – PubChem

In the next few decades, the world population will flourish. As the population grows rapidly and people all over the world use more and more resources, all industries must consider their environmental impact. 24242-20-4, name is 5-Aminopicolinic acid, the common compound, a new synthetic route is introduced below. Quality Control of 5-Aminopicolinic acid

To a solution of 5-aminopicolinic acid (194 mg, 1.40 mmol) in ethanol (5 mL), was added thionyl chloride (0.20 mL, 2.80 mmol) at 0 C. The mixture was then stirred under reflux for 19 h, after which time it was cooled to room temperature and the reaction mixture concentrated under reduced pressure. Saturated aqueous sodium carbonate solution was added to the resulting solid to adjust the pH to 9, followed by saturated aqueous sodium hydrogen carbonate. Ethyl acetate (10 mL) and water (10 mL) were added and the organic phase was washed with brine (1 0 mL), dried (Na2SO4), filtered and the filtrate concentrated in vacuo. Ethyl 5-aminopicolinate (184 mg, 79%) was obtained as an off-white solid, with no need for further purification; 1H NMR (500 MHz, MeOD) 6 1 .37 (3H, t, J = 7.1 Hz, CH3), 4.35 (2H, q, J = 7.2 Hz), 7.02 (1H, dd, J = 2.7 and 8.6 Hz, Ar), 7.85 (1H, d, J = 8.6 Hz) and 7.98 (1H, d, J= 2.7 Hz). LRMS(ESI÷) mz 167.2 [M + H].

The synthetic route of 24242-20-4 has been constantly updated, and we look forward to future research findings.

Reference:
Patent; CANCER RESEARCH TECHNOLOGY LIMITED; REUILLON, Tristan; MILLER, Duncan; MYERS, Stephanie; MOLYNEUX, Lauren; CANO, Celine; HARDCASTLE, Ian; RIGOREAU, Laurent; GOLDING, Bernard; NOBLE, Martin; (246 pag.)WO2016/42341; (2016); A1;,
Pyridine – Wikipedia,
Pyridine | C5H5N – PubChem

Application of 20885-12-5, The major producers of chemicals have been the Europe, Japan and China. Due to the growing call for a cleaner, greener environment, people will have to find innovative ways to maintain their relevance. Here is a compound 20885-12-5, name is 2-Chloro-6-fluoropyridine. This compound has unique chemical properties. The synthetic route is as follows.

To a solution of diisopropylamine (5.26 mL) in THF (70 mL) was added at -78C nBuLi 1.6M in hexanes (21.6 mL). The mixture was stirred at 0C for 45 min. 2-Chloro-6-fluoropyridine (3.5g) in THF (36 mL) was added dropwise at -78C over 1 h under nitrogen to the previous mixture and the reaction mixture was stirred at -78C for 1.5h. DMF (4.12 mL) was added dropwise over 1 h and the reaction mixture was stirred an additional 1 .5h. HCI 2M in diethylether (45 mL) was added slowly at -78C, water (30 mL) was added and the layers were separated. The aq. phase was extracted with EA and the combined org. layers were washed with sat. aq. NaCI, dried over Na2S04, filtrated off and evaporated in vacuo. The crude (4.4g of an orange solid) was used without purification in the next step. GC-MS (A): tR = 1 .55 min; [M+H]+: 159.80.

According to the analysis of related databases, 20885-12-5, the application of this compound in the production field has become more and more popular.

Reference:
Patent; ACTELION PHARMACEUTICALS LTD; BUR, Daniel; GRISOSTOMI, Corinna; NAYLER, Oliver; REMEN, Lubos; VERCAUTEREN, Magali; WELFORD, Richard; WO2015/75023; (2015); A1;,
Pyridine – Wikipedia,
Pyridine | C5H5N – PubChem

The major producers of chemicals have been the Europe, Japan and China. Due to the growing call for a cleaner, greener environment, people will have to find innovative ways to maintain their relevance. Here is a compound 131747-42-7, name is 6-(Trifluoromethyl)picolinic acid. This compound has unique chemical properties. The synthetic route is as follows. Quality Control of 6-(Trifluoromethyl)picolinic acid

6-Trifluoromethylpyridine-2-carboxylic acid (25 g, 130.8 mmol) was dissolved in 300 mL of methanol, and thionyl chloride (23.3 g, 196.2 mmol) was added dropwise. After addition, the mixture was refluxed for reaction for 12 h. The resultant solution was concentrated untill dry, and saturated sodium hydrogen carbonate solution was added to adjust the pH, and then the resultant was extracted with ethyl acetate, dried over anhydrous sodium sulfate to give the title compound.

With the rapid development of chemical substances, we look forward to future research findings about 131747-42-7.

Reference:
Patent; Nanjing Sanhome Pharmaceutical Co., Ltd.; WANG, Yong; ZHAO, Liwen; LIU, Xiaorong; ZHANG, Yan; HUANG, Dandan; JIANG, Chunhuan; SHI, Xinsheng; GU, Hongfeng; PANG, Silin; HAI, Wei; GE, Bingyang; (71 pag.)EP3489230; (2019); A1;,
Pyridine – Wikipedia,
Pyridine | C5H5N – PubChem

Adding a certain compound to certain chemical reactions, such as: 106850-34-4, Imidazo[1,2-a]pyridine-6-carbonitrile, can increase the reaction rate and produce products with better performance than those obtained under traditional synthetic methods. Here is a downstream synthesis route of the compound, 106850-34-4, blongs to pyridine-derivatives compound. Safety of Imidazo[1,2-a]pyridine-6-carbonitrile

EXAMPLE 93 7beta-[2-(5-Amino-1,2,4-thiadiazol-3-yl)-2(Z)-ethoxyiminoacetamido]-3-[(6-cyanoimidazo[1,2-a]pyridinium-1-yl)methyl]-3-cephem-4-carboxylate STR150 The compound obtained in Reference Example 28 is reacted with 6-cyanoimidazo[1,2-a]pyridine in the procedure of Example 42 to give the above-identified compound. Elemental analysis for C22 H19 N9 O5 S2.4H2 O: Calcd. (%): C, 42.24; H, 4.35; N, 20.15. Found (%): C, 42.12; H, 3.90; N, 19.97. IR spectrum numaxKBr cm-1: 2250, 1760, 1620, 1525. NMR spectrum (d6 -DMSO)delta: 1.19(3H, t, J=7 Hz), 2.98 and 3.44 (2H, ABq, J=18 Hz), 4.12 (2H, q, J=7 Hz), 5.00 (1H, d, J=5 Hz), 5.1-5.6 (2H, m), 5.66 (1H, d. d, J=5 Hz & 8 Hz), 8.10 (2H, br. s), 8.2-9.0 (4H, m), 9.42 (1H, d, J=8 Hz), 9.76 (1H, br. s).

These compound has a wide range of applications. It is believed that with the continuous development of the source of the synthetic route,106850-34-4, its application will become more common.

Reference:
Patent; Takeda Chemical Industries, Ltd.; US4788185; (1988); A;,
Pyridine – Wikipedia,
Pyridine | C5H5N – PubChem

Synthetic Route of 17874-79-2, Adding some certain compound to certain chemical reactions, such as: 17874-79-2, name is 5-(Methoxycarbonyl)picolinic acid,molecular formula is C8H7NO4, can increase the reaction rate and produce products with better performance than those obtained under traditional synthetic methods. Here is a downstream synthesis route of the compound 17874-79-2.

[00455] To a solution of 5-methoxycarbonylpyridine-2-carboxylic acid (0.5 g, 2.76 mmol) in DCM (10 mL) was added (COCl2)2 (1.7 g, 13.8 mmol) and a drop of DMF at 0C, the resulting mixture was stirred at room temperature (approximately 25 C) for 1 hour, at which point TLC showed the reaction was over. The reaction mixture was concentrated to give methyl 6-chlorocarbonylpyridine-3-carboxylate. To a solution of EtMgBr (2.76 mL, 1 M in THF, 2.76 mmol) was added a solution of indol (315 mg, 2.7 mmol) in ether (anhydrous, 10 mL). The resulting two-phase system was allowed to stand for 15 min under stirring whereupon ZnCl2 (370 mg, 2.7 mmol) was added with stirring. The two-phase system was allowed to stand for 30 min when compound methyl 6- chlorocarbonylpyridine-3-carboxylate (560 mg, 2.76 mmol) in anhydrous ether (5 ml) was added. The reaction mixture was stirred at room temperature (approximately 25 C) for 2 hours, whereupon NFLC1 (15 ml) was added. The reaction mixture was diluted with water, extracted with DCM, dried over Na2S04, concentrated and purified by SGC (PE: EA=l5:l) to give the title compound, yield 24%, as a yellow syrup. 1H NMR (300 MHz, DMSO-de) 4.03 (s, 3H), 6.66 (d, J = 4.0 Hz, 1H), 7.31-7.42 (m, 2H), 7.60 (d, / = 7.6 Hz, 1H), 7.92 (d, / = 3.6 Hz, 1H), 8.16 (d, J = 8.0 Hz, 1H), 8.52-8.54 (m, 2H), 9.32 (s, 1H), MS (ESI+): m/z calc for[CieH NiOs] 280.08, Found: 281.6[M+H]+.

In the field of chemistry, the synthetic routes of compounds are constantly being developed and updated. I will also mention this compound in other articles. 17874-79-2, 5-(Methoxycarbonyl)picolinic acid, other downstream synthetic routes, hurry up and to see.

Reference:
Patent; BETH ISRAEL DEACONESS MEDICAL CENTER, INC.; CHAIKOF, Elliot; SUN, Lijun; (224 pag.)WO2019/195682; (2019); A1;,
Pyridine – Wikipedia,
Pyridine | C5H5N – PubChem

As we all know, there are many different methods for the synthesis of a compound, and people can choose the synthesis method that suits their own laboratory according to the actual situation. 607373-83-1, name is 2-Chloro-4-methoxy-5-nitropyridine, molecular formula is C6H5ClN2O3, The compound is widely used in many fields, so it is necessary to find a new synthetic route. The downstream synthesis method of this compound is introduced below. Recommanded Product: 607373-83-1

To a solution of 2-chloro-4-methoxy-5-nitro-pyridine (26 mmol) in dry THF (50 mL) at room temperature was added methyl amine (25 mL) (2M in THF). The mixture was allowed to stir for a further 2 h at room temperature. After completion of reaction as seen by TLC and LCMS, solvent was evaporated under reduced pressure to give 5 g of desired Intermediate 1. [00260] ‘H-NMR (400 MHz, DMSO-i: delta 2.95 (d, 3H), 7.01 (s, 1H), 8.57 (bs, 1H), 8.86, 1H). [00261] Mass (M+l): m/z 188.

With the rapid development of chemical substances, we look forward to future research findings about 607373-83-1.

Reference:
Patent; GALAPAGOS NV; MENET, Christel; SCHMITT, Benoit; GENEY, Raphael; DOYLE, Kevin; PEACH, Joanne; PALMER, Nicholas; JONES, Graham; HARDY, David; DUFFY, James; WO2013/117649; (2013); A1;,
Pyridine – Wikipedia,
Pyridine | C5H5N – PubChem

Each compound has different characteristics, and only by selecting the characteristics of the compound suitable for a specific situation can the compound be applied on a large scale. 769-28-8, name is 4,6-Dimethyl-2-oxo-1,2-dihydropyridine-3-carbonitrile. This compound has unique chemical properties. The synthetic route is as follows. Recommanded Product: 4,6-Dimethyl-2-oxo-1,2-dihydropyridine-3-carbonitrile

2-Chloro-4, 6-dimethylnicotinonitrile4,6-Dimethyl-2-oxo-l,2-dihydropyridine-3-carbonitrile (5g, 34mmol) was added to phosphorus oxychloride (20ml). The reaction was stirred at reflux for 2 h, after which it was seen complete. Volatiles were removed and the residue triturated with petrol.The resultant solid was filtered off and washed with hexane,and dried to give a pure white solid (5.1g, 90%). deltaH (250 MHz, CDCl3) 2.55 (3 H, s, CH3), 2.57 (3 H, s, CH3),7.09 (1 H, s, ArH); deltac ( 250 MHz, CDCl3) 162.64 (C), 154.39 (C), 152.26 (C), 123.22 (CH), 114.28 (C), 108.31 (C), 24.5 (CH3), 20.54 (CH3).; m/z 189 (M + Na)

If you are interested in these compounds, you can also browse my other articles.Thank you for taking the time to read this article. I hope you enjoyed it, 769-28-8, 4,6-Dimethyl-2-oxo-1,2-dihydropyridine-3-carbonitrile.

Reference:
Patent; CYCLACEL LIMITED; CANCER RESEARCH TECHNOLOGY LIMITED; WO2008/122767; (2008); A2;,
Pyridine – Wikipedia,
Pyridine | C5H5N – PubChem

Adding a certain compound to certain chemical reactions, such as: 1122-71-0, 6-Methyl-2-pyridinemethanol, can increase the reaction rate and produce products with better performance than those obtained under traditional synthetic methods. Here is a downstream synthesis route of the compound, Formula: C7H9NO, blongs to pyridine-derivatives compound. Formula: C7H9NO

Diphenylphosphoryl azide (8.02 g, 29.16 mmol) was added to a cooled (0 C.) solution of 6-methyl2-pyridinemethanol (3.00 g, 24.30 mmol) in ether. The resulting mixture was stirred for a few minutes and DBU (4.07 g, 26.73 mmol) was added slowly. The reaction mixture was stirred for 14 hours, decanted into a clean flask and the residue was washed with more ether. The combined organic phases were concentrated to give the crude title azido compound. The crude azide was dissolved in THF:H2O (3:1) and Ph3P (5.77 g, 22.00 mmol) was added, followed by KOH (1.23 g, 22.00 mmol). The reaction mixture was stirred for 14 hours, and then was acidified with concentrated HCl. The resulting solution was washed with Et2O and the aqueous layer was basified with NH3 and extracted with Et2O (3×200 mL). The combined organic extracts were washed with H2O (3×100 mL) and brine (1×100 mL), then dried over MgSO4 and concentrated to give the desired substituted benzylamine. Spectroscopic data: 1H NMR (300 MHz, Acetone-d6) delta 2.52 (s, 3H) 3.91 (s, 2H) 7.04 (d, J=7.61 Hz, 1H) 7.05 (d, J=7.90 Hz, 1H) 7.51 (t, J=7.82 Hz, 1H).

The synthetic route of 1122-71-0 has been constantly updated, and we look forward to future research findings.

Reference:
Patent; Allerghan, Inc.; US2008/194650; (2008); A1;,
Pyridine – Wikipedia,
Pyridine | C5H5N – PubChem