Day: May 28, 2021

Reference of 633328-33-3, The major producers of chemicals have been the Europe, Japan and China. Due to the growing call for a cleaner, greener environment, people will have to find innovative ways to maintain their relevance. Here is a compound 633328-33-3, name is 3-Bromo-1H-pyrazolo[4,3-b]pyridine. This compound has unique chemical properties. The synthetic route is as follows.

Step 2: Preparation of 3-Bromo-l-(4-methoxybenzyl)-lH-pyrazolo[4,3-b]pyridine(Exp-l-g3)[0087] Into 8 mL of DMF was placed 1.0 g of Exp-l-g2 (5 mmol) prepared in Step 1 , 0.94 g p-methoxybenzylchloride (PMBC1, 6 mmol) and 1.38g K2C03 (10 mmol). The reaction mixture thus provided was stirred for 3 hours while maintaining it at 100 C. At the end of this time the reaction mixture was diluted with 150 mL ethylacetate (EtOAc). The diluted mixture was washed sequentially with ali quotes of brine then water, dried over MgSC>4, filtered, and concentrated. The concentrate solution thus provided was purified via silica column chromatogram (PE:EtOAc = 8: 1) and after the eluting solvent was evaporated gave Exp-l-g3 as a yellow solid (1.2 g, 75 %).

According to the analysis of related databases, 633328-33-3, the application of this compound in the production field has become more and more popular.

Reference:
Patent; MERCK SHARP & DOHME CORP; ADDEX PHARMA S.A.; LIVERTON, Nigel; JONES, Philip; BOLEA, Christelle; CELANIRE, Sylvain; TANG, Lam; BOUDOU, Cedric; LEI, Zhiyu; LIU, Fuqing; LUO, Yunfu; DONG, Jingchao; SOLL, Richard; WO2013/60029; (2013); A1;,
Pyridine – Wikipedia,
Pyridine | C5H5N – PubChem

Synthetic Route of 189281-66-1, Adding some certain compound to certain chemical reactions, such as: 189281-66-1, name is Methyl 2,6-dichloro-5-fluoronicotinate,molecular formula is C7H4Cl2FNO2, can increase the reaction rate and produce products with better performance than those obtained under traditional synthetic methods. Here is a downstream synthesis route of the compound 189281-66-1.

1st Step 2-methoxy ethanol (423 mul) and sodium hydride (60% in oil) (196 mg) were added to a THF (10 ml) solution containing methyl 2,6-dichloro-5-fluoronicotinate (1 g) under ice cooling in a nitrogen atmosphere, followed by stirring for 1.5 hours. Water was added to the reaction solution, followed by extraction with ethyl acetate. The organic layers were washed with saturated saline and dried over anhydrous sodium sulfate. The solvent was distilled away under reduced pressure and yellow oily matter of methyl 2-chloro-5-fluoro-6-(2-methoxyethoxy)nicotinate (1.07 g) was thus obtained. MS (ESI m/z): 264 (M+H)

In the field of chemistry, the synthetic routes of compounds are constantly being developed and updated. I will also mention this compound in other articles. 189281-66-1, Methyl 2,6-dichloro-5-fluoronicotinate, other downstream synthetic routes, hurry up and to see.

Reference:
Patent; FUJIFILM Corporation; FUJIWARA, Hideyasu; MIZUMOTO, Shinsuke; KUBO, Yohei; NAKATA, Hiyoku; HAGIWARA, Shinji; BABA, Yasutaka; TAMURA, Takashi; KUNIYOSHI, Hidenobu; MASHIKO, Tomoyuki; YAMAMOTO, Mari; US2014/309225; (2014); A1;,
Pyridine – Wikipedia,
Pyridine | C5H5N – PubChem

As we all know, there are many different methods for the synthesis of a compound, and people can choose the synthesis method that suits their own laboratory according to the actual situation. 74784-70-6, name is 5-(Trifluoromethyl)pyridin-2-amine, molecular formula is C6H5F3N2, The compound is widely used in many fields, so it is necessary to find a new synthetic route. The downstream synthesis method of this compound is introduced below. Quality Control of 5-(Trifluoromethyl)pyridin-2-amine

To a solution of phenyl carbonochloridate (1.72 g, 1 1.0 mmol) in dichloromethane (20.0 ml_) was added 5-(trifluoromethyl)pyridin-2-amine (1.62 g, 10.0 mmol) at room temperature under N2. Pyridine (0.870 g, 1 1.0 mmol) was then added to the reaction at 0 C and the resulting mixture stirred for 0.5 h. The reaction mixture was poured into water and extracted with ethyl acetate followed by drying with sodium sulfate. After concentration, the residue was purified with the column chromatography (eluent: dichloromethane: petroleum ether (1 :2)) to afford 1.2 g of the title compound. NMR (400 MHz, DMSO) d 1 1 .24 (s, 1 H), 8.70 (d, J = 0.9 Hz, 1 H), 8.18 (dd, J = 8.9, 2.3 Hz, 1 H), 7.99 (d, J = 8.8 Hz, 1 H), 7.43 (dd, J = 1 1.0, 4.8 Hz, 2H), 7.31 – 7.18 (m, 3H).

With the rapid development of chemical substances, we look forward to future research findings about 74784-70-6.

Reference:
Patent; SYNGENTA CROP PROTECTION AG; SYNGENTA CHINA INVESTMENT COMPANY LIMITED; SCHAETZER, Juergen, Harry; BIGOT, Aurelien; JUNG, Pierre, Joseph, Marcel; STOLLER, Andre; GAGNEPAIN, Julien, Daniel, Henri; HALL, Roger, Graham; RENDINE, Stefano; LU, Long; YANG, Jianzhong; CHEN, Ruifang; (113 pag.)WO2020/30754; (2020); A1;,
Pyridine – Wikipedia,
Pyridine | C5H5N – PubChem

Adding a certain compound to certain chemical reactions, such as: 52313-50-5, Picolinimidamide, can increase the reaction rate and produce products with better performance than those obtained under traditional synthetic methods. Here is a downstream synthesis route of the compound, 52313-50-5, blongs to pyridine-derivatives compound. Safety of Picolinimidamide

Example 90 5-(2-Fluoro-4-methoxy-benzyl)-2-pyridin-2-yl-pyrimidine-4,6-diamine In a similar fashion using route 17 general procedure 55, pyridine-2-carboxamidine (100 mg, 0.83 mmol), 2-(2-fluoro-4-methoxy-benzyl)-malononitrile (186 mg, 0.91 mmol) and NaOMe (89 mg, 1.65 mmol) gave the title compound (14 mg, 5%) after purification by trituration from MeCN/Et2O.

These compound has a wide range of applications. It is believed that with the continuous development of the source of the synthetic route,52313-50-5, its application will become more common.

Reference:
Patent; VIFOR (INTERNATIONAL) AG; US2012/202806; (2012); A1;,
Pyridine – Wikipedia,
Pyridine | C5H5N – PubChem

Each compound has different characteristics, and only by selecting the characteristics of the compound suitable for a specific situation can the compound be applied on a large scale. 1201326-81-9, name is Methyl 5-(methylsulfonyl)picolinate. This compound has unique chemical properties. The synthetic route is as follows. Application In Synthesis of Methyl 5-(methylsulfonyl)picolinate

Compound 3 (8.6 g, 20 mmol) was added to methanol/water (60 mL / 20 mL)And LiOH (3.3 g, 80 mmol). The reaction mixture was stirred at room temperature for 2 hours.The reaction mixture was acidified to pH = 6, and the precipitate was separated by filtration.The filtered precipitate was dissolved in dichloromethane (100 mL) and a catalytic amount of DMF was added.Then, oxalyl chloride (6.8 g, 54 mmol) was slowly added dropwise at 0 C.The temperature was raised to room temperature and held for 2 hours. Then remove the solvent,The mixture was dissolved in CH 2 Cl 2 (100 mL).Et3N (13.8 mL, 108 mmol) was added.Stir for 5 minutes,N,O-Dimethylhydroxylamine hydrochloride (5.3 g, 54 mmol) was added.The reaction was continued to stir at room temperature for 30 minutes.Water (40 mL) was added to the reaction mixture and water was applied sequentially.Wash with saturated brine. The organic phase was collected and dried over anhydrous MgSO4.The solvent was removed to give the product 4 (7.3 g, 82%).

If you are interested in these compounds, you can also browse my other articles.Thank you for taking the time to read this article. I hope you enjoyed it, 1201326-81-9, Methyl 5-(methylsulfonyl)picolinate.

Reference:
Patent; Beijing Yuan Bo Fang Pharmaceutical Technology Co., Ltd.; Li Jing; (26 pag.)CN104926797; (2019); B;,
Pyridine – Wikipedia,
Pyridine | C5H5N – PubChem

Related Products of 75806-84-7, Researchers who often do experiments know that organic synthesis is a process of preparing more complex target molecules from simple raw materials through one or more chemical reactions. Generally, it requires fewer steps,and cheap raw materials. 75806-84-7, name is 2-Bromo-3-chloro-5-(trifluoromethyl)pyridine. A new synthetic method of this compound is introduced below.

Example 63 10-Chloro-1-[3-chloro-5-(trifluoromethyl)pyridin-2-yl]-7-(1-ethylpropyl)-2,3,4,5-tetrahydro-1H-[1,3]diazepino[1,2-a]benzimidazole A mixture of 10-chloro-7-(1-ethylpropyl)-2,3,4,5-tetrahydro-1H-[1,3]diazepino[1,2-a]benzimidazole (Reference Example 72; 150 mg, 0.51 mmol), 2-bromo-3-chloro-5-(trifluoromethyl)pyridine (401 mg, 1.54 mmol), copper(I) iodide (97 mg, 0.51 mmol), 2,2′-bipyridyl (159 mg, 1.02 mmol) and cesium carbonate (333 mg, 1.02 mmol) in 1-methyl-2-pyrrolidinone (2.0 mL) was stirred at 150 C. for 16 hr. The mixture was diluted with ethyl acetate, filtered through a pad of celite, washed with 2N hydrochloric acid, water and brine, dried over anhydrous sodium sulfate and concentrated in vacuo. The residue was purified by flash chromatography on silica gel eluding with a 5-20% ethyl acetate/n-hexane gradient mixture. The filtrate was concentrated in vacuo to give a residue, which was purified by preparative HPLC to give a solid, which was recrystallized from n-hexane/ethyl acetate to give the title compound (104 mg, 0.221 mmol, 43%) as a colorless solid. mp 108-110 C. 1H NMR (CDCl3) delta 0.87 (t, J=7.3 Hz, 6H), 1.67-2.13 (m, 8H), 3.02-3.19 (m, 1H), 4.18-4.28 (m, 2H), 4.48-4.56 (m, 2H), 6.99 (d, J=8.3 Hz, 1H), 7.21 (d, J=8.3 Hz, 1H), 7.73-7.85 (m, 1H), 8.43-8.57 (m, 1H). MS Calcd.: 470; Found: 471 (M+H).

At the same time, in my other blogs, there are other synthetic methods of this type of compound,75806-84-7, 2-Bromo-3-chloro-5-(trifluoromethyl)pyridine, and friends who are interested can also refer to it.

Reference:
Patent; TAKEDA PHARMACEUTICAL COMPANY LIMITED; US2009/186879; (2009); A1;,
Pyridine – Wikipedia,
Pyridine | C5H5N – PubChem

Related Products of 846021-26-9, The major producers of chemicals have been the Europe, Japan and China. Due to the growing call for a cleaner, greener environment, people will have to find innovative ways to maintain their relevance. Here is a compound 846021-26-9, name is 2-Amino-6-methylnicotinic acid. This compound has unique chemical properties. The synthetic route is as follows.

2-Amino-6-methyl nicotinic acid (3.04 g) was suspended in N,N-dimethylformamide (60 mL), and potassium carbonate (5.53 g) was added to the suspension, followed by stirring at 40 C. for 30 minutes. Solution (I) was dropwise added to the resulting suspension, followed by stirring with heating at 80 C. for 2 hours. The reaction solution was cooled to room temperature, and the N,N-dimethylformamide (45 mL, 64%) was removed by distillation under reduced pressure. Iced water (100 mL) was added to the residue, followed by stirring at room temperature for minutes. Precipitated crystals were collected by filtration and were dried to give 6.42 g (yield: 92%) of the target product (Compound 4 shown in Table 1). According to purity analysis by liquid chromatography, the purity of thus obtained target product was high, 99.1%. A melting point thereof was 94 C. to 96 C.10058] ?H-NMR (CDC13) oeppm: 2.33 (3H, s), 2.40 (3H, s), 5.27 (2H, s), 6.08-6.82 (2H, br), 6.44 (1H, d), 6.90-7.00 (5H, m), 7.14 (2H, d), 7.37 (2H, d), 8.02 (1H, d)

According to the analysis of related databases, 846021-26-9, the application of this compound in the production field has become more and more popular.

Reference:
Patent; AGRO-KANESHO CO., LTD.; AIZAWA, Ryo; OKADA, Itaru; (8 pag.)US2016/318868; (2016); A1;,
Pyridine – Wikipedia,
Pyridine | C5H5N – PubChem

With the rapid development and complex challenges of chemical substances, the synthesis of new drugs is usually one of the most effective ways to increase yield.171919-36-1, name is 1-Methyl-1H-pyrrolo[2,3-b]pyridine-3-carboxaldehyde, molecular formula is C9H8N2O, molecular weight is 160.17, as common compound, the synthetic route is as follows.COA of Formula: C9H8N2O

c) 1-Methyl-3-(methylaminomethyl)-1H-pyrrolo[2,3-b]pyridine According to the procedure of Preparation 40 (c), except substituting 1-methyl-1H-pyrrolo[2,3-b]pyridine-3-carboxaldehyde (0.4 g, 2.5 mmole) for the 1,3-dimethyl-1H-indole-2-carboxaldehyde, the title compound (0.2 g, 45%) was prepared as a yellow oil: MS (ES) m/e 176 (M + H)+.

At the same time, in my other blogs, there are other synthetic methods of this type of compound,171919-36-1, 1-Methyl-1H-pyrrolo[2,3-b]pyridine-3-carboxaldehyde, and friends who are interested can also refer to it.

Reference:
Patent; Affinium Pharmaceuticals, Inc.; EP1226138; (2004); B1;,
Pyridine – Wikipedia,
Pyridine | C5H5N – PubChem

Reference of 874959-68-9, The major producers of chemicals have been the Europe, Japan and China. Due to the growing call for a cleaner, greener environment, people will have to find innovative ways to maintain their relevance. Here is a compound 874959-68-9, name is 5-Bromopyridine-2-sulfonyl chloride. This compound has unique chemical properties. The synthetic route is as follows.

A mA mixture of 5-bromo-2-pyridinesulfonyl chloride (0.30Og, 1.17mmol), pyrrolidine (0.0976ml, 1.17mmol) and TEA (0.326ml, 2.34mmol) in anhydrous DCM (6ml) was stirred at room temperature under nitrogen overnight. The reaction mixture was partitioned between DCM (20ml) and water (20ml), the layers separated and the DCM extract evaporated in vacuo to give the title compound as a pale brown solid (0.367g).MH+ = 293, rt = 2.74 min

While traditionally a conservative industry, chemical producers will need to modernize their PR strategies to stay relevant.we look forward to future research findings about 874959-68-9, 5-Bromopyridine-2-sulfonyl chloride.

Reference:
Patent; GLAXO GROUP LIMITED; WO2008/145688; (2008); A2;,
Pyridine – Wikipedia,
Pyridine | C5H5N – PubChem

Electric Literature of 59663-96-6, The major producers of chemicals have been the Europe, Japan and China. Due to the growing call for a cleaner, greener environment, people will have to find innovative ways to maintain their relevance. Here is a compound 59663-96-6, name is Ethyl 4-(hydroxymethyl)picolinate. This compound has unique chemical properties. The synthetic route is as follows.

A mixture of 13.9 g of ethyl 4-(hydroxymethyl)-pyridine-2-carboxylate, 5 g platinum oxide in 250 ml acetic acid is hydrogenated at 50 lbs/in2. Filtration, concentration in vacuo, and neutralization with potassium carbonate in methylene chloride yields an oil that is purified by flash chromatography using methylene chloride/methanol saturated with ammonia (20:1) to yield ethyl 4-(hydroxymethyl)-piperidine-2-carboxylate.

According to the analysis of related databases, 59663-96-6, the application of this compound in the production field has become more and more popular.

Reference:
Patent; Ciba-Geigy Corporation; US4906621; (1990); A;,
Pyridine – Wikipedia,
Pyridine | C5H5N – PubChem